Explanipedia

Medical Training on Climate Change and Health: Evaluation of an Online Learning Format for Outpatient Care Open

Merle Klanke, Claudia Quitmann, Jessica Nieder, Jörg Lindenthal, E. Alvarez , et al. · 2025

Background: Climate change increasingly affects public health and presents new challenges for outpatient care. Physicians require specific training opportunities to address these developments. As part of the project AdaptNet (“Adapting pri…

A de novo dominant-negative PSMB8 mutation causes severe CANDLE/PRAAS due to arrested proteasome biogenesis Open

Sophie Wolfgramm, Sara Alehashemi, Franziska G. Thiel, Adriana A. de Jesus, Jonas Johannes Papendorf , et al. · 2025

The DN-PSMB8 p.G209R variant broadens the clinical and mechanistic PRAAS spectrum by causing 20S proteasome maturation arrest and uncovering a convergence between mitochondrial dysfunction and the ISR. Our findings implicate cytopenia in a…

Single-versus multiple-inhaler triple therapy in patients with COPD in Spain: a retrospective cohort study comparing adherence, persistence, risk of exacerbations and economic outcomes Open

Mirna González‐González, M. Aránzazu Pedrosa-Naudín, Diego Fernández‐Lázaro, Isabel Díaz Planelles, E. Alvarez , et al. · 2025

This retrospective study aimed to compare the clinical and economic outcomes of single-inhaler triple therapy (SITT) versus multiple-inhaler triple therapy (MITT) in a large cohort of COPD patients. Metrics on adherence, prevalence, and in…

Intestinal Subocclusion Due to Rapunzel Syndrome in a Female with Cerebral Palsy Open

E. Alvarez, Nora Lis Flores Olmos, C Sánchez, Antonio Arroyo, Irving Othoniel Zavala Cid · 2025

Rapunzel syndrome is a rare variant of trichobezoar characterized by a hair mass extending from the stomach into the duodenum. Management depends on the severity of clinical presentation and the bezoar's size and location, with surgery oft…

Nationwide analysis of COVID-19 complications, outcomes, and costs of childbirth in Spain Open

Blanca Álvarez-del Río, Laura Sánchez-de Prada, Irene Arroyo-Hernantes, E. Alvarez, Eduardo Tamayo , et al. · 2025

Introduction Pregnant women are considered a vulnerable group for COVID-19 with an increased risk for complications. The objective of this study is to describe in-hospital mortality, pregnancy outcomes, and direct hospital costs associated…

Newly Started Versus Previously Treated Statin Patients: A Retrospective Cohort Study Comparing Adherence and Persistence with Reference to Cardiovascular Prevention Open

Marta Martín-Fernández, Mirna González‐González, M. Aránzazu Pedrosa-Naudín, Diego Fernández‐Lázaro, E. Alvarez , et al. · 2025

Background/Objectives: Cardiovascular disease (CVD) remains the leading cause of death worldwide, and the effectiveness of statin therapy is critically dependent on patient adherence and persistence. The aim of this study was to evaluate a…

Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol Open

Alicia Wendy Vega Harwood, Marta Fernández‐González, Carlos Ezquer, E. Alvarez, Rocío López-Herrero , et al. · 2025

Background: Sepsis is a major global health issue and the leading cause of death in critically ill patients, with rising incidence and associated healthcare costs. Early administration of antibiotic therapy is crucial, but increasing antib…

Is there a risk of esketamine misuse in clinical practice? Open

Carlos Roncero, Milton Merizalde Torres, Néstor Szerman, Marta Torrens, Pablo Vega , et al. · 2025

In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitti…

Assessing Climate Change-Related Health Hazards: An Interactive Tool for Regional Risk Analysis in Germany Open

Irena Kaspar‐Ott, E. Alvarez, Philipp Köhn, Paul Gäbel, Alina Herrman , et al. · 2025

Estimation of Health Risks from Climate Change-Related Hazards Using the Example of Nuremberg, Germany Open

E. Alvarez, Irena Kaspar‐Ott, Alina Herrman, Claudia Quitmann, Jessica Nieder , et al. · 2025

Non-adherence to antidementia medications and associated factors: a study of Spanish population-based registry data Open

Eduardo Gutiérrez‐Abejón, M. Aránzazu Pedrosa-Naudín, Diego Fernández‐Lázaro, Isabel Díaz Planelles, E. Alvarez · 2024

Introduction With an increasing prevalence, dementia is one of the most disabling diseases among the elderly. Impaired cognitive function and behavioral and psychological symptoms predispose patients to medication non-adherence, resulting …

Improved Design Standard for High TemperatureMolten Nitrate Salt Tank Design Open

E. Alvarez, G. W. Thorp, Thomas E. Lorentz, Sudhakar Neti, H. F. Nied · 2024

The Preliminary Design Guide Outline is intended to create a first iteration of the sections of the future Molten Salt Design guide, with an emphasis on gaps in the current industry accepted standard base that already exists. This outline …

Prelacrimal window approach to the maxillary sinus: a systematic review and meta-analysis of the literature Open

André De Sousa Machado, Joana B. Pereira, E. Alvarez, Hans Rudolf Briner, Daniel Simmen · 2024

BACKGROUND: The prelacrimal window approach (PLWA) is a minimally invasive surgical technique that has been proposed as an alternative to the traditional approaches to access the maxillary sinus. METHODOLOGY: A systematic review with meta-…

Medication economic burden of antidepressant non-adherence in Spain Open

Eduardo Gutiérrez‐Abejón, M. Aránzazu Pedrosa-Naudín, Diego Fernández‐Lázaro, E. Alvarez · 2023

Introduction: Non-adherence to antidepressants is associated with worse disease outcomes (morbidity and mortality) and correlates with higher healthcare resource utilization and costs. Methods: A population-based registry study was conduct…

Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia coli isolated from patients with gastroenteritis Quito, Ecuador Open

Gabriela Vera, E. Alvarez, Carolina Satán, Katherine Jaramillo · 2023

Introducción Las bacterias multirresistentes han ido aumentando con el pasar de los años, por lo que presentan una problemática a nivel global, principalmente la resistencia a los betalactámicos en entornos hospitalarios y comunitarios. La…

Prevalence and cost of hospitalized patients with asymptomatic COVID-19 in 2020 in Spain Open

Blanca Álvarez-del Río, Laura Sánchez-de Prada, Alejandro Álvaro‐Meca, Marta Martín-Fernández, E. Alvarez , et al. · 2023

Introduction COVID-19 transmission has been characterized by the presence of asymptomatic patients. Additionally, most studies evaluating costs focus on symptomatic COVID-19 cases. Objective To describe the prevalence, characteristics, and…

Increase in driving after cocaine use in Spain: a cross-sectional dataset analysis for 2021 Open

Mercedes García-Mingo, Marta Martín-Fernández, Eduardo Gutiérrez‐Abejón, E. Alvarez · 2023

Objective Driving under the influence of alcohol and/or drugs impairs skills essential for safe driving, increases the risk of being involved in a traffic accident and is particularly prevalent in Spain. The aim is to assess the prevalence…

Environmental factors are associated to hospital outcomes in COVID-19 patients during lockdown and post-lockdown in 2020: A nationwide study Open

Laura Sánchez-de Prada, José María Eiros-Bachiller, Álvaro Tamayo-Velasco, Marta Martín-Fernández, E. Alvarez , et al. · 2023

Short-term exposure to air pollutants impacts COVID-19 out-comes during the lockdown, especially PM_2.5, PM₁₀, NO₂, and SO2. These pollutants are associated with hospital admission, hospital mortality and IC…

Trends in the Use of Driving-Impairing Medicines According to the DRUID Category: A Population-Based Registry Study with Reference to Driving in a Region of Spain between 2015 and 2019 Open

Eduardo Gutiérrez‐Abejón, Paloma Criado-Espegel, M. Aránzazu Pedrosa-Naudín, Diego Fernández‐Lázaro, Francisco Herrera‐Gómez , et al. · 2023

The European DRUID (Drive Under the Influence of drugs, alcohol, and medicines) program classifies medications into three categories according to their effect on one’s fitness to drive. The trend in the use of driving-impairing medicines (…

Endothelin Receptor Antagonists in Kidney Disease Open

Irene Martínez-Díaz, Nerea Martos, Carmen Llorens-Cebrià, E. Alvarez, Patricia W. Bedard , et al. · 2023

Endothelin (ET) is found to be increased in kidney disease secondary to hyperglycaemia, hypertension, acidosis, and the presence of insulin or proinflammatory cytokines. In this context, ET, via the endothelin receptor type A (ETA) activat…

Economic Burden of the 2020 COVID-19 Hospitalizations in Spain Open

Blanca Álvarez-del Río, Laura Sánchez-de Prada, Alejandro Álvaro‐Meca, Marta Martín-Fernández, E. Alvarez , et al. · 2023

This economic evaluation reports the total and per patient costs of inpatient care for COVID-19 in Spain in 2020.

Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study Open

M. Aránzazu Pedrosa-Naudín, Eduardo Gutiérrez‐Abejón, Francisco Herrera‐Gómez, Diego Fernández‐Lázaro, E. Alvarez · 2022

Antidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registr…

Corrigendum to ‘Influence of the implant scan body bevel location, implant angulation and position on intraoral scanning accuracy: An in vitro study’ [Journal of Dentistry volume 121 (2022) 104122] Open

Miguel Gómez‐Polo, E. Alvarez, Rocío Ortega, Cristina Gómez‐Polo, Abdul Basir Barmak , et al. · 2022

Integration of Supercritical Carbon Dioxide Cooling Loop for G3P3 Primary Heat Exchanger. Open

E. Alvarez · 2022

Development and Procurement of Major Components for Gen3 CSP Pilot Plant Cooling Loop . Open

E. Alvarez · 2022

Túnel aorto-ventricular izquierdo Open

María Florencia Nuñez, Evangelina Papini, Martín Irazusta, E. Alvarez, Marcela Vyera , et al. · 2022

Declaración de conflictos de interesesLos autores declaran que no

Hospitalized COVID-19 Patients with Severe Acute Respiratory Syndrome: A Population-Based Registry Analysis to Assess Clinical Findings, Pharmacological Treatment and Survival Open

Eduardo Gutiérrez‐Abejón, Francisco Herrera‐Gómez, M. Aránzazu Pedrosa-Naudín, Eduardo Tamayo, E. Alvarez · 2022

Background and Objectives: One of the most serious clinical outcomes in hospitalized patients with COVID-19 is severe acute respiratory syndrome (SARS). The aim is to analyze pharmacological treatment, survival and the main mortality predi…

ABO Blood System and COVID-19 Susceptibility: Anti-A and Anti-B Antibodies Are the Key Points Open

Álvaro Tamayo-Velasco, María Jesús Peñarrubia-Ponce, E. Alvarez, Ignacio de la Fuente, Sonia Pérez González , et al. · 2022

The implication of the ABO blood group in COVID-19 disease was formulated early, at the beginning of the COVID-19 pandemic more than 2 years ago. It has now been established that the A blood group is associated with more susceptibility and…

Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality Open

Marta Martín-Fernández, María Heredia‐Rodríguez, Irene González-Jiménez, Mario Lorenzo‐López, Estefanía Gómez‐Pesquera , et al. · 2022

DOE's National Solar Thermal Test Facility Operations and Maintenance (Final Report FY19-21) Open

E. Alvarez · 2021

Sandia National Laboratories has been tasked to operate and maintain the National Solar Thermal Test Facility (NSTTF) located in Kirtland Airforce Base near Albuquerque, NM. The NSTTF provides established test platforms and experienced res…

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