Carlos Henrique Tomich de Paula da Silva
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View article: Medicina regenerativa na ortopedia: avanços em biomateriais e terapias celulares
Medicina regenerativa na ortopedia: avanços em biomateriais e terapias celulares Open
This article presents a literature review on the advances of regenerative medicine applied to orthopedics, focusing on the use of biomaterials, cell therapies, and nanotechnology for bone and cartilage regeneration. Studies published betwe…
View article: Pharmacophore-Based Virtual Screening of Alkaloids and Flavonoids for Designing Drugs with Inhibitory Activity on the Enzyme Monoamine Oxidase B
Pharmacophore-Based Virtual Screening of Alkaloids and Flavonoids for Designing Drugs with Inhibitory Activity on the Enzyme Monoamine Oxidase B Open
Parkinson’s disease is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, resulting in multiple motor and cognitive impairments. Among the hypotheses proposed for its etiology, oxidative stress mediated…
View article: Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on <i>T. cruzi</i> and <i>Trans</i> ‐ <i>Sialidase</i>
Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on <i>T. cruzi</i> and <i>Trans</i> ‐ <i>Sialidase</i> Open
Chagas disease, caused by the protozoan Trypanosoma cruzi , affects 6–7 million people worldwide, mainly in South and Central America. A key enzyme in the disease's progression is Trypanosoma cruzi trans‐sialidase ( TcTS ), which facilitat…
View article: A Protocol for the Characterization of Diatom Communities in Mountain Glaciers
A Protocol for the Characterization of Diatom Communities in Mountain Glaciers Open
This research presents a significant contribution to the methodologies and protocols for studying diatom communities in cryoconite holes on glaciers. Cryoconite holes are unique microenvironments found on glacial surfaces that support intr…
View article: B-338 Real-world data shows the effectiveness of a tetravalent vaccine against Human Papilloma Virus types 16 and 18 in Chilean women
B-338 Real-world data shows the effectiveness of a tetravalent vaccine against Human Papilloma Virus types 16 and 18 in Chilean women Open
Background Cervical uterine cancer (CUCa) is the fourth most common female neoplasm globally. At least 99% of CUCa cases are caused by persistent infection of high-risk Human Papillomavirus (HR-HPV) types. In 2014, Chile began a mandatory …
View article: In silico Screening of Monamine Oxidase B Inhibitors for the Treatment of Central Nervous System Disorders
In silico Screening of Monamine Oxidase B Inhibitors for the Treatment of Central Nervous System Disorders Open
Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the …
View article: Expression of Truncated Products at the 5′-Terminal Region of <i>RIPK2</i> and Evolutive Aspects that Support Their Biological Importance
Expression of Truncated Products at the 5′-Terminal Region of <i>RIPK2</i> and Evolutive Aspects that Support Their Biological Importance Open
Alternative splicing is the process of generating different mRNAs from the same primary transcript, which contributes to increase the transcriptome and proteome diversity. Abnormal splicing has been associated with the development of sever…
View article: GDP-mannose pyrophosphorylase is an efficient target in <i>Xanthomonas citri</i> for citrus canker control
GDP-mannose pyrophosphorylase is an efficient target in <i>Xanthomonas citri</i> for citrus canker control Open
Xanthomonas citri subsp. citri (Xcc) is a bacterium that causes citrus canker, an economically important disease that results in premature fruit drop and reduced yield of fresh fruit. In this study, we demonstrated the involvement of XanB,…
View article: Vicia sativa subsp. sativa native to the Middle East comprises Pea Albumin1 b-like homologs: A promising natural biopesticide
Vicia sativa subsp. sativa native to the Middle East comprises Pea Albumin1 b-like homologs: A promising natural biopesticide Open
The extensive and indiscriminate use of chemical pesticides in agriculture has led to adverse effects on human health, environmental pollution, and the emergence of pesticide-resistant pests. To mitigate these challenges, the development o…
View article: Structure-based drug design for protein arginine deiminase Type IV (PAD4) receptor: Chemoinformatics approach
Structure-based drug design for protein arginine deiminase Type IV (PAD4) receptor: Chemoinformatics approach Open
Rheumatoid Arthritis (RA) is the second most common type of arthritis with symptoms first appearing in patients between 40 and 60 years of age. The number of older persons is projected to double to 1.5 billion in 2050, globally. Peptidylar…
View article: Diversity of Insecticidal PA1b Homologs among Legume Seeds from Middle Eastern Region
Diversity of Insecticidal PA1b Homologs among Legume Seeds from Middle Eastern Region Open
Legumes play a central role in various food systems, with significant socio-economic and environmental impacts. Their high protein content, composed mainly of globulins and albumins, makes them valuable for human food and animal feed. Amon…
View article: New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling
New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling Open
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, …
View article: Hierarchical Virtual Screening Based on Rocaglamide Derivatives to Discover New Potential Anti-Skin Cancer Agents
Hierarchical Virtual Screening Based on Rocaglamide Derivatives to Discover New Potential Anti-Skin Cancer Agents Open
Skin Cancer (SC) is among the most common type of cancers worldwide. The search for SC therapeutics using molecular modeling strategies as well as considering natural plant-derived products seems to be a promising strategy. The phytochemic…
View article: Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran
Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran Open
Kefiran is a polysaccharide present in kefir grains that have been widely explored due to its potential health benefits. The objective of this work was to characterize and quantify the components present in the ethanolic extract of milk ke…
View article: New triazole triterpene derivative exhibits anti-RSV activity synthesis biological evaluation and molecular modeling
New triazole triterpene derivative exhibits anti-RSV activity synthesis biological evaluation and molecular modeling Open
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, ho…
View article: Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro
Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has received global attention due to the serious threat it poses to public health. Since the outbreak in December 2019, millions o…
View article: Revisiting the Proposition of Binding Pockets and Bioactive Poses for GSK-3β Allosteric Modulators Addressed to Neurodegenerative Diseases
Revisiting the Proposition of Binding Pockets and Bioactive Poses for GSK-3β Allosteric Modulators Addressed to Neurodegenerative Diseases Open
Glycogen synthase kinase-3 beta (GSK-3β) is an enzyme pertinently linked to neurodegenerative diseases since it is associated with the regulation of key neuropathological features in the central nervous system. Among the different kinds of…
View article: Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity
Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity Open
Search for new pharmacological alternatives for obesity is based on the design and development of compounds that can aid in weight loss so that they can be used safely and effectively over a long period while maintaining their function. Th…
View article: Identification of Known Drugs As Potential SARS-CoV-2 Mpro Inhibitors Using ligand- and Structure-Based Virtual Screening
Identification of Known Drugs As Potential SARS-CoV-2 Mpro Inhibitors Using ligand- and Structure-Based Virtual Screening Open
Background: The new coronavirus pandemic has had a significant impact worldwide, and therapeutic treatment for this viral infection is being strongly pursued. Efforts have been undertaken by medicinal chemists to discover molecules or know…
View article: Identification of novel potential cyclooxygenase-2 inhibitors using ligand- and structure-based virtual screening approaches
Identification of novel potential cyclooxygenase-2 inhibitors using ligand- and structure-based virtual screening approaches Open
Cyclooxygenase 2 (COX-2) is a well-established target for the design of anti-inflammatory intermediates. Celecoxib was selected as a template molecule to perform ligand-based virtual screening, i.e. to search for structures with similarity…
View article: Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches Open
Adenosine Receptor Type 2A (A2AAR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for compounds by pharmacophore-based virtual screening. The pharmacokinetic/toxicological…
View article: The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance Open
Aspergillus fumigatus is an opportunistic human pathogen causing allergic reactions or systemic infections, such as invasive pulmonary aspergillosis in immunocompromised patients. The mitogen-activated protein kinase (MAPK) signaling pathw…
View article: Molecular Modeling of Substances Isolated from the Essential Oil of the Species Drimys angustifolia and Drimys brasiliensis
Molecular Modeling of Substances Isolated from the Essential Oil of the Species Drimys angustifolia and Drimys brasiliensis Open
Objectives: Carry out an in silico study of chemical substances isolated from the species: Drimys angustifolia and Drimys brasiliensis. Methods: A theoretical study of global reactivity, QSAR descriptors, MEP construction and molecular doc…
View article: Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening
Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening Open
Leukemias are neoplasms that affect hematopoietic cells, which are developed by genetic alterations (mutations) that lead to the loss of proliferation control mechanisms (maturation and/or cell death). The α4β1 integrin receptor is a thera…
View article: Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review
Antioxidant Effect of Flavonoids Present in Euterpe oleracea Martius and Neurodegenerative Diseases: A Literature Review Open
Introduction: Neurodegenerative diseases (NDDs) are progressive, directly affecting the central nervous system (CNS), the most common and recurrent are Alzheimer's disease (AD) and Parkinson's disease (PD). One factor frequently mentioned …
View article: Identification of Potential Inhibitors from Pyriproxyfen with Insecticidal Activity by Virtual Screening
Identification of Potential Inhibitors from Pyriproxyfen with Insecticidal Activity by Virtual Screening Open
Aedes aegypti is the main vector of dengue fever transmission, yellow fever, Zika, and chikungunya in tropical and subtropical regions and it is considered to cause health risks to millions of people in the world. In this study, we search …
View article: Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism
Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism Open
A drug design for safer phenylbutazone was been explored by reactivity and docking studies involving single electron transfer mechanism, as well as toxicological predictions. Several approaches about its structural properties were performe…
View article: Evidence of a noncoding transcript of the<i>RIPK2</i>gene overexpressed in head and neck tumor
Evidence of a noncoding transcript of the<i>RIPK2</i>gene overexpressed in head and neck tumor Open
Receptor-interacting proteins are a family of serine/threonine kinases, which integrate extra and intracellular stress signals caused by different factors, including infections, inflammation and DNA damage. Receptor-interacting serine/thre…