E. Haydn Walters
YOU?
Author Swipe
View article: Paradigm shifts in asthma: what is old is new again
Paradigm shifts in asthma: what is old is new again Open
View article: DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage
DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage Open
DNA methylation (5mC) is an epigenetic mark that plays a critical role in defining cell fate. Following fertilisation, DNA methylation inherited from gametes must be reprogrammed to establish totipotency and enable the parental-to-zygotic …
View article: Parental smoke exposure before age 15 and offspring asthma trajectories from ages 7 to 53
Parental smoke exposure before age 15 and offspring asthma trajectories from ages 7 to 53 Open
Background and objective Paternal passive smoke exposure before age 15 years was associated with offspring childhood asthma, but its association with asthma beyond childhood had not been investigated. We aimed to investigate such long-term…
View article: Paternal prepubertal passive smoke exposure is related to impaired lung function trajectories from childhood to middle age in their offspring
Paternal prepubertal passive smoke exposure is related to impaired lung function trajectories from childhood to middle age in their offspring Open
Introduction Paternal prepubertal passive smoke exposure may increase the risk of childhood asthma. However, its association with impaired lung function trajectories at risk of chronic obstructive pulmonary disease in offspring was not inv…
View article: Targeting pathogen adhesion molecules to improve COPD outcomes
Targeting pathogen adhesion molecules to improve COPD outcomes Open
View article: Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study
Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study Open
Background Predicting shorter life expectancy is crucial for prioritising antifibrotic therapy in fibrotic lung diseases (FLDs), where progression varies widely, from stability to rapid deterioration. This heterogeneity complicates treatme…
View article: Concavity of the maximal expiratory flow-volume curve and incidence of COPD and respiratory symptoms: a population-based cohort study
Concavity of the maximal expiratory flow-volume curve and incidence of COPD and respiratory symptoms: a population-based cohort study Open
Background Concavity of the maximal expiratory flow-volume curve is widely regarded as an early indicator of obstructive airways disease. However, its discriminatory accuracy for respiratory outcomes has remained poorly defined. Objective …
View article: Using implementation strategies to promote the maintenance of Kids SIPsmartER in rural Appalachian middle schools: a process evaluation
Using implementation strategies to promote the maintenance of Kids SIPsmartER in rural Appalachian middle schools: a process evaluation Open
Clincialtrials.gov: NCT03740113. Registered 14 November 2018 - Retrospectively registered. https://clinicaltrials.gov/study/NCT03740113 .
View article: Ten-year exposure to household air pollution is associated with obstructive sleep apnoea
Ten-year exposure to household air pollution is associated with obstructive sleep apnoea Open
Sustained exposure to wood and gas heating and gas cooking especially when combined with tobacco smoke increased the risk of OSA over 10 years in middle age. Our study strengthens the rationale for including the potential adverse effects o…
View article: General population-based lung function trajectories over the life course: an accelerated cohort study
General population-based lung function trajectories over the life course: an accelerated cohort study Open
View article: Associations Between Occupational Exposures and Cough Subclasses Among Middle‐Aged Australians
Associations Between Occupational Exposures and Cough Subclasses Among Middle‐Aged Australians Open
Background and Objective The evidence around occupation‐related chronic cough is conflicting and current definitions of chronic cough cannot capture its heterogeneity. Using our recently characterised novel cough subclasses, we aimed to id…
View article: Multiple at-risk groups have lower lung function during the grass pollen season
Multiple at-risk groups have lower lung function during the grass pollen season Open
View article: Early‐to‐Midlife Body Mass Index Trajectories and Obstructive Sleep Apnoea Risk 10 Years Later
Early‐to‐Midlife Body Mass Index Trajectories and Obstructive Sleep Apnoea Risk 10 Years Later Open
Background and Objective While short‐term weight changes are known to influence obstructive sleep apnoea (OSA), the impact of body mass index (BMI) changes over the life course has been poorly documented. We examined the association betwee…
View article: Pre‐Treatment <scp>MMP7</scp> Predicts Progressive Idiopathic Pulmonary Fibrosis in Antifibrotic Treated Patients
Pre‐Treatment <span>MMP7</span> Predicts Progressive Idiopathic Pulmonary Fibrosis in Antifibrotic Treated Patients Open
Background and Objective Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a poor prognosis. Antifibrotics slow the decline of pulmonary function after 12‐months, but limited studies have examined the role of c…
View article: Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid‐Adulthood: Data From the Tasmanian Longitudinal Health Study
Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid‐Adulthood: Data From the Tasmanian Longitudinal Health Study Open
Background and Objective The impact of lifetime body mass index (BMI) trajectories on adult lung function abnormalities has not been investigated previously. We investigated associations of BMI trajectories from childhood to mid‐adulthood …
View article: College athlete recovery starts with proteins and carbohydrates: Why post-exercise nutrition matters more than you think
College athlete recovery starts with proteins and carbohydrates: Why post-exercise nutrition matters more than you think Open
View article: Trends in smoking initiation and cessation over a century in two Australian cohorts
Trends in smoking initiation and cessation over a century in two Australian cohorts Open
Background Historical data on smoking can enhance our comprehension of the effectiveness of past tobacco control policies and play a key role in developing targeted public health interventions. This study was undertaken to assess trends in…
View article: Reply to Divo and Celli: To Our Knowledge, You Are Not the First…
Reply to Divo and Celli: To Our Knowledge, You Are Not the First… Open
"Reply to Divo and Celli: To Our Knowledge, You Are Not the First…." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades
Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades Open
Introduction Evidence on the early life risk factors of adult CRS, and the history of asthma and allergies across the life course, is limited. Aim To investigate relationships between respiratory infective/allergic conditions in childhood,…
View article: Unravelling the health and economic burden of interstitial lung diseases in adults in Australia
Unravelling the health and economic burden of interstitial lung diseases in adults in Australia Open
Recent research has demonstrated that idiopathic pulmonary fibrosis (IPF) is the most frequent ILD in Australia. Incidence and prevalence of IPF have demonstrated an increasing trend over the past decades. Mortality has also increased over…
View article: Chronic Bronchitis in Children and Adults: Definitions, Pathophysiology, Prevalence, Risk Factors, and Consequences
Chronic Bronchitis in Children and Adults: Definitions, Pathophysiology, Prevalence, Risk Factors, and Consequences Open
The complex nature of chronic bronchitis (CB) and changing definitions have contributed to challenges in understanding its aetiology and burden. In children, CB is characterised by persistent airway inflammation often linked to bacterial i…
View article: Machine Learning Provides a Novel Approach to Increasing the Accuracy and Applicability of Circulatory Biomarkers in the Management of Idiopathic Pulmonary Fibrosis
Machine Learning Provides a Novel Approach to Increasing the Accuracy and Applicability of Circulatory Biomarkers in the Management of Idiopathic Pulmonary Fibrosis Open
View article: Author Correction: A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts
Author Correction: A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts Open
View article: Inhaled corticosteroids with combination inhaled long-acting beta2-agonists and long-acting muscarinic antagonists for chronic obstructive pulmonary disease
Inhaled corticosteroids with combination inhaled long-acting beta2-agonists and long-acting muscarinic antagonists for chronic obstructive pulmonary disease Open
The available evidence suggests that triple therapy may reduce rates of COPD exacerbations (low-certainty evidence) and results in an improvement in health-related quality of life (high-certainty evidence) compared to combination LABA/LAMA…
View article: Disease burden, comorbidities and antecedents of chronic cough phenotypes in Australian adults
Disease burden, comorbidities and antecedents of chronic cough phenotypes in Australian adults Open
Chronic cough is prevalent in middle-age and a high proportion is unexplained. Unexplained cough contributes to poor lung function and increased comorbidities. Given unexplained chronic cough is not a symptom of major underlying respirator…
View article: Associations of early life and childhood risk factors with obstructive sleep apnoea in middle‐age
Associations of early life and childhood risk factors with obstructive sleep apnoea in middle‐age Open
Background and Objective Early‐life risk factors for obstructive sleep apnoea (OSA) are poorly described, yet this knowledge may be critical to inform preventive strategies. We conducted the first study to investigate the association betwe…
View article: A chronic obstructive pulmonary disease risk assessment tool in preventive lung healthcare: An unmet need?
A chronic obstructive pulmonary disease risk assessment tool in preventive lung healthcare: An unmet need? Open
IN AUSTRALIA, the all-encompassing role of general practice in managing acute and chronic conditions, while also delivering preventive healthcare to promote and maintain optimal health, is well recognised as challenging but critical to mai…
View article: A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts Open
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes and placentitis. However, the pathophysiological mechanisms underpinning SARS-CoV-2 infection during placentati…
View article: Long‐term exposure to low concentrations of air pollution and decline in lung function in people with idiopathic pulmonary fibrosis: Evidence from Australia
Long‐term exposure to low concentrations of air pollution and decline in lung function in people with idiopathic pulmonary fibrosis: Evidence from Australia Open
Background and Objective Little is known about the association between ambient air pollution and idiopathic pulmonary fibrosis (IPF) in areas with lower levels of exposure. We aimed to investigate the impact of air pollution on lung functi…
View article: Life course BMI trajectories from childhood to mid-adulthood are differentially associated with anxiety and depression outcomes in middle age
Life course BMI trajectories from childhood to mid-adulthood are differentially associated with anxiety and depression outcomes in middle age Open
Background/Objective Obesity is a risk factor for multimorbidity, including depression and possibly anxiety. However, it is currently unclear how patterns of change in BMI over the life course differentially influence the magnitude in risk…