E. Jane Costello
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View article: PFAS and Altered Glucose Homeostasis in Adolescents following Bariatric Surgery
PFAS and Altered Glucose Homeostasis in Adolescents following Bariatric Surgery Open
Objective Bariatric surgery is an effective treatment for severe obesity and associated metabolic comorbidities. Exposure to PFAS before bariatric surgery may attenuate improvements in glucose metabolism and explain some of the heterogenei…
View article: Ultra-processed food intake is associated with altered glucose homeostasis in young adults with a history of overweight or obesity: a longitudinal study
Ultra-processed food intake is associated with altered glucose homeostasis in young adults with a history of overweight or obesity: a longitudinal study Open
UPF consumption may increase the risk for T2D among young adults. Our findings suggest that limiting UPF consumption could be an important strategy for T2D prevention in this population.
View article: <scp>PFAS</scp> Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen‐<scp>LABS</scp> Study
<span>PFAS</span> Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen‐<span>LABS</span> Study Open
Objective Weight regain following bariatric surgery remains a clinical challenge, with limited understanding of contributing environmental factors. Per‐ and polyfluoroalkyl substances (PFAS), persistent chemicals linked to metabolic dysfun…
View article: Ultra-Processed Food Intake is Associated with Altered Glucose Homeostasis in Young Adults
Ultra-Processed Food Intake is Associated with Altered Glucose Homeostasis in Young Adults Open
View article: Chrome Plating Facility Siting Is Associated with Neighborhood Demographic and Socioeconomic Factors and Elevated Per- and Polyfluoroalkyl Substances in Blood in California
Chrome Plating Facility Siting Is Associated with Neighborhood Demographic and Socioeconomic Factors and Elevated Per- and Polyfluoroalkyl Substances in Blood in California Open
Chrome plating facilities release toxic chemicals, including perfluoroalkyl and polyfluoroalkyl substances (PFAS), disproportionately affecting nearby neighborhoods. We analyzed census-tract-level demographic and socioeconomic data using t…
View article: Corrigendum to “Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: a multicohort study” [Environ. Int 185 (2024) 108454]
Corrigendum to “Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: a multicohort study” [Environ. Int 185 (2024) 108454] Open
View article: Thiamine deficiency in US veterans with obesity
Thiamine deficiency in US veterans with obesity Open
Introduction Thiamine deficiency is common after bariatric surgery, but patients with obesity may be deficient in thiamine even before surgery. The purpose of this research was to determine the prevalence of thiamine deficiency in patients…
View article: Proteins and pathways involved in inflammation are longitudinally associated with total body bone mineral density among primarily Hispanic overweight/obese adolescents and young adults
Proteins and pathways involved in inflammation are longitudinally associated with total body bone mineral density among primarily Hispanic overweight/obese adolescents and young adults Open
BMD, an important marker of bone health, is regulated by a complex interaction of proteins. Plasma proteomic analyses can contribute to identification of proteins associated with changes in BMD. This may be especially informative in stages…
View article: The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults: A proof-of-concept study
The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults: A proof-of-concept study Open
View article: Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins
Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins Open
View article: Exposure to Perfluoroalkyl Substances is Associated with Longitudinal Changes in Adiposity in a Hispanic Adolescent Cohort
Exposure to Perfluoroalkyl Substances is Associated with Longitudinal Changes in Adiposity in a Hispanic Adolescent Cohort Open
View article: PFAS are associated with perturbations of lipid metabolism in adolescents
PFAS are associated with perturbations of lipid metabolism in adolescents Open
View article: Associations Between PFAS and Longitudinal Changes in Insulin Sensitivity in Adolescents
Associations Between PFAS and Longitudinal Changes in Insulin Sensitivity in Adolescents Open
View article: Coupling observational study with computational toxicology to elucidate the relationships and potential mechanisms of per-and polyfluoroalkyl substances and sleep
Coupling observational study with computational toxicology to elucidate the relationships and potential mechanisms of per-and polyfluoroalkyl substances and sleep Open
View article: Association between per- and polyfluoroalkyl substances (PFAS) exposure and kidney function in young adults
Association between per- and polyfluoroalkyl substances (PFAS) exposure and kidney function in young adults Open
View article: Cardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults
Cardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults Open
View article: Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth
Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth Open
PFAS was associated with broad alterations of the proteomic profiles linked to pro-inflammation and immunoregulation. The biological functions of these proteins provide insight into potential molecular mechanisms of PFAS toxicity.
View article: Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: A multicohort study
Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: A multicohort study Open
View article: Proteomic and Metabolomic Signatures of Diet Quality in Young Adults
Proteomic and Metabolomic Signatures of Diet Quality in Young Adults Open
The assessment of “omics” signatures may contribute to personalized medicine and precision nutrition. However, the existing literature is still limited in the homogeneity of participants’ characteristics and in limited assessments of integ…
View article: Assessment of Autonomic Nervous System Activity Using Spectral Analysis of Heart Rate Variability After Continuous Positive Airway Pressure (CPAP) Therapy in Patients With Sleep Apnea
Assessment of Autonomic Nervous System Activity Using Spectral Analysis of Heart Rate Variability After Continuous Positive Airway Pressure (CPAP) Therapy in Patients With Sleep Apnea Open
View article: A long and winding road: culture change on data sharing in exposomics
A long and winding road: culture change on data sharing in exposomics Open
Data sharing requires cooperation from data generators (eg, epidemiologists, lab investigators) and data users (eg, epidemiologists, biostatisticians, computer scientists). Data generation and data use in human exposome studies require sig…
View article: Exposure to perfluoroalkyl substances and longitudinal changes in bone mineral density in adolescents and young adults: A multi-cohort study
Exposure to perfluoroalkyl substances and longitudinal changes in bone mineral density in adolescents and young adults: A multi-cohort study Open
View article: Per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers and dysregulation of MicroRNA expression in humans and animals—A systematic review
Per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers and dysregulation of MicroRNA expression in humans and animals—A systematic review Open
View article: Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers with oxidative stress markers: A systematic review and meta-analysis
Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers with oxidative stress markers: A systematic review and meta-analysis Open
View article: Exposure to ambient air pollutants, serum miRNA networks, lipid metabolism, and non-alcoholic fatty liver disease in young adults
Exposure to ambient air pollutants, serum miRNA networks, lipid metabolism, and non-alcoholic fatty liver disease in young adults Open
Exposure to AAP may contribute to adverse lipid profiles and NAFLD risk among young adults via altered expression of microRNA profiles.
View article: Exposure to per- and polyfluoroalkyl substances and plasma proteomics in young adults: The Meta-AIR study
Exposure to per- and polyfluoroalkyl substances and plasma proteomics in young adults: The Meta-AIR study Open
View article: Bottled Water Consumption and Per- and Polyfluorinated Alkyl Substances (PFAS): Findings from the MetaAIR Study and NHANES 2003-2018
Bottled Water Consumption and Per- and Polyfluorinated Alkyl Substances (PFAS): Findings from the MetaAIR Study and NHANES 2003-2018 Open
BACKGROUND AND AIM: Contamination of drinking water with per- and polyfluoroalkyl substances (PFAS) is a growing concern, especially in areas experiencing drought or water insecurity. Populations with concerns about water quality often cho…
View article: Ambient air pollution and serum cardiometabolic proteome in young adults with obesity history
Ambient air pollution and serum cardiometabolic proteome in young adults with obesity history Open
BACKGROUND AND AIM: Current evidence of air pollution exposure and blood proteomic markers is mostly based on a small number of markers (such as TNF-α, IL6, CRP and fibrinogen) cross-sectionally and have demonstrated mixed results. In this…
View article: Exposure to Perfluoroalkyl Substances and Longitudinal Changes in Bone Mineral Density in Adolescents and Young Adults: A Multi-Cohort Study
Exposure to Perfluoroalkyl Substances and Longitudinal Changes in Bone Mineral Density in Adolescents and Young Adults: A Multi-Cohort Study Open
View article: Exposure to Perfluoroalkyl Substances and Longitudinal Changes in Bone Mineral Density in Adolescents and Young Adults: A Multi-Cohort Study
Exposure to Perfluoroalkyl Substances and Longitudinal Changes in Bone Mineral Density in Adolescents and Young Adults: A Multi-Cohort Study Open