Marcelo Farías
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Neonatal anthropometry outcomes comparing two gestational weight gain standards Open
Objectives: The gestational weight gain chart published by Rosso and Mardones (RM) was used by the Ministry of Health in Argentina from the 1990s until 2009, when it was replaced by the Calvo et al. chart (CEA). This study compared the dia…
View article: Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Mice
Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Mice Open
Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammatio…
Homeostatic macrophages prevent preterm birth and improve neonatal outcomes by mitigating <i>in utero</i> sterile inflammation Open
SUMMARY Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inf…
Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy Open
Pregnancies are a critical window period for environmental influences over the mother and the offspring. There is a growing body of evidence associating indoor and outdoor air pollution exposure to adverse pregnancy outcomes such as preter…
The Vaginal Microbiota in Early Pregnancy Identifies a Subset of Women at Risk for Early Preterm Prelabor Rupture of Membranes and Preterm Birth Open
Spontaneous preterm birth (sPTB) can occur when vaginal bacteria gain access to the amniotic cavity. Thus, the predictive value of the vaginal microbiota for sPTB has been investigated, yet results have been inconclusive. Here, we report t…
Pregnancy imparts distinct systemic adaptive immune function Open
Problem Pregnancy represents a state of systemic immune activation that is primarily driven by alterations in circulating innate immune cells. Recent studies have suggested that cellular adaptive immune components, T cells and B cells, als…
View article: Fetal and maternal NLRP3 signaling is required for preterm labor and birth
Fetal and maternal NLRP3 signaling is required for preterm labor and birth Open
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria. However, the molecular mechanisms underlyin…
The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis Open
In brief The syndrome of preterm labor comprises multiple established and novel etiologies. This review summarizes the distinct immune mechanisms implicated in preterm labor and birth and highlights potential strategies for its prevention.…
S13.3 <i>(Oral Abstract Presentation)</i>: Autoimmune Regulator (AIRE) – Hypoxia inducing factor 1A (HIF1A) Rendezvous: An indication of low circulating treg in polycystic ovarian syndrome Open
tions of IP-10, VEGF, and TARC slightly increased.Women who ultimately underwent sPTB had decreased concentrations of VEGF while concentrations of MIP-1β, MIP-1α, IL-6, IL-1β, MCP-1, IL-16, IFN-γ, IL-4, IL-12/IL-23p40, IL-17A, IL-10, IL-8,…
View article: Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women Open
Pregnant women are at increased risk of adverse outcomes, including preeclampsia and preterm birth, that may result from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Pregnancy imprints specific maternal immune re…
Additional file 1 of Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal–fetal inflammation in mice Open
Additional file 1. RT-qPCR gene expression data. -ΔCT values for gene expression in the maternal and fetal tissues from mice treated with clarithromycin (CLR) or DMSO (vehicle control) reported in this study.
View article: Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth Open
The complex physiologic process of parturition includes the onset of labor, which requires the orchestrated stimulation of a common pathway involving uterine contractility, cervical ripening, and chorioamniotic membrane activation. However…
Comparison of Three Gestational Weight Gain Guidelines Under Use in Latin America Open
Presently, three guidelines are used in Latin America to assess adequacy of maternal body mass index (BMI) during pregnancy: (1) the chart proposed by the Institute of Medicine of the United States (IOM), (2) the Rosso-Mardones Chart (RM),…
Folate status in women of childbearing age in the Urban Metropolitan Region of Chile: results from the National Health Survey 2016–2017 Open
Objective: To analyse serum folate levels in women of childbearing age in the Metropolitan Region (MR) of Chile. Design: Cross-sectional design as part of the 2016–2017 National Health Survey ( Encuesta Nacional de Salud, ENS 2016–2017 ), …
Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women´s Weight: Possible Impact on Feto-Placental Vascular Function Open
Gestational diabetes mellitus (GDM) associates with fetal endothelial dysfunction (ED), which occurs independently of adequate glycemic control. Scarce information exists about the impact of different GDM therapeutic schemes on maternal dy…