Luiz E. Mello
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View article: Neuroprotective Effects of Acute Biperiden Treatment Following Traumatic Brain Injury in Male Rats
Neuroprotective Effects of Acute Biperiden Treatment Following Traumatic Brain Injury in Male Rats Open
Traumatic brain injury (TBI) remains a leading cause of morbidity and mortality, with no effective treatments available. Biperiden, a muscarinic receptor antagonist, has demonstrated neuroprotective effects by modulating neural plasticity …
View article: DIREITO ADMINISTRATIVO: DESAFIOS E EVOLUÇÃO HISTÓRICA NO BRASIL
DIREITO ADMINISTRATIVO: DESAFIOS E EVOLUÇÃO HISTÓRICA NO BRASIL Open
O objetivo desta pesquisa foi analisar os desafios e a evolução histórica do Direito Administrativo no Brasil, compreendendo os impactos dessas transformações na administração pública. A metodologia adotada foi uma revisão bibliográfica, n…
View article: Anabolic steroid abuse alters the neurovasculome: an intracranial pressure analysis study in bodybuilders
Anabolic steroid abuse alters the neurovasculome: an intracranial pressure analysis study in bodybuilders Open
Introduction Anabolic steroids are used to enhance physical performance and increase muscle mass. Approximately one-third of users develop psychological alterations characterized by cognitive deficits and antisocial or aggressive behavior.…
View article: Anabolic steroid abuse accelerates arterial ageing
Anabolic steroid abuse accelerates arterial ageing Open
Introduction The indiscriminate use of steroids for aesthetic and performance purposes has been increasing exponentially. Elevated blood pressure is common among users, but little is known about the mechanisms causing this increase in bloo…
View article: Effects of guideline-based treatment on the cardiopulmonary responses to exercise in patients with steroid-induced cardiomyopathy
Effects of guideline-based treatment on the cardiopulmonary responses to exercise in patients with steroid-induced cardiomyopathy Open
Introduction The indiscriminate use of steroids has been increasing exponentially. The cardiopulmonary exercise test (CPET) is the gold standard method for clinical follow-up, prognostic evaluation, and treatment guidance for patients with…
View article: Two-year longitudinal and prospective electroencephalographic follow-up in patients with TBI: can early EEG and CT findings predict post-traumatic epilepsy?
Two-year longitudinal and prospective electroencephalographic follow-up in patients with TBI: can early EEG and CT findings predict post-traumatic epilepsy? Open
This comprehensive approach provides valuable insights for clinical management and sheds light on the complex interplay of factors influencing TBI outcomes.
View article: Standardizing the Lateral Fluid Percussion Model of Trauma in Marmosets: Regional Vulnerability and Inflammatory Response
Standardizing the Lateral Fluid Percussion Model of Trauma in Marmosets: Regional Vulnerability and Inflammatory Response Open
View article: Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury—a randomized clinical trial
Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury—a randomized clinical trial Open
There is currently no efficacious intervention for preventing post-traumatic epilepsy (PTE). Preclinical studies support the potential use of anticholinergics for this condition. The purpose of this study was to evaluate the effects of bip…
View article: miR-9-5p is downregulated in serum extracellular vesicles of patients treated with biperiden after traumatic brain injury
miR-9-5p is downregulated in serum extracellular vesicles of patients treated with biperiden after traumatic brain injury Open
Traumatic brain injury (TBI) is a prevalent and debilitating condition, which often leads to the development of post-traumatic epilepsy (PTE), a condition that yet lacks preventive strategies. Biperiden, an anticholinergic drug, is a promi…
View article: Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury. A Randomized Clinical Trial
Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury. A Randomized Clinical Trial Open
There is currently no available drug to prevent the development of post-traumatic epilepsy. insufficient evidence regarding the effect of biperiden in preventing post-traumatic epilepsy after TBI. The combined effect of variables known to …
View article: Anticholinergics: A potential option for preventing posttraumatic epilepsy
Anticholinergics: A potential option for preventing posttraumatic epilepsy Open
Interest in the use of anticholinergics to prevent the development of epilepsy after traumatic brain injury (TBI) has grown since recent basic studies have shown their effectiveness in modifying the epileptogenic process. These studies dem…
View article: Temporal pattern of Fos and Jun families expression after mitogenic stimulation with FGF-2 in rat neural stem cells and fibroblasts
Temporal pattern of Fos and Jun families expression after mitogenic stimulation with FGF-2 in rat neural stem cells and fibroblasts Open
Intense stimulation of most living cells triggers the activation of immediate early genes, such as Fos and Jun families. These genes are important in cellular and biochemical processes, such as mitosis and cell death. The present study foc…
View article: Early life nociceptive stimulus and fentanyl exposure increase hippocampal neurogenesis and anxiety but do not affect spatial learning and memory
Early life nociceptive stimulus and fentanyl exposure increase hippocampal neurogenesis and anxiety but do not affect spatial learning and memory Open
This study aimed to determine whether preemptive fentanyl administration in neonatal rats reduces the impact of a nociceptive stimulus initiated during the first day of life (P1) on hippocampal neurogenesis, behavior, and learning. At P1, …
View article: Biperiden for prevention of post-traumatic epilepsy: A protocol of a double-blinded placebo-controlled randomized clinical trial (BIPERIDEN trial)
Biperiden for prevention of post-traumatic epilepsy: A protocol of a double-blinded placebo-controlled randomized clinical trial (BIPERIDEN trial) Open
Background Traumatic brain injury (TBI) is one of the most important causes of acquired structural epilepsy, post-traumatic epilepsy (PTE), however, efficient preventative measures and treatment are still not available to patients. Preclin…
View article: Anxious Profile Influences Behavioral and Immunohistological Findings in the Pilocarpine Model of Epilepsy
Anxious Profile Influences Behavioral and Immunohistological Findings in the Pilocarpine Model of Epilepsy Open
Anxiety and epilepsy have a complex bidirectional relationship, where a depressive/anxious condition is a factor that can trigger seizures which in turn can aggravate the depressive/anxious condition. In addition, brain structures such as …
View article: Two decades of research towards a potential first anti-epileptic drug
Two decades of research towards a potential first anti-epileptic drug Open
The basic mechanisms by which brain insults, such as trauma, stroke or status epilepticus produce epilepsy are not completely understood, and effective preventive measures and treatment are still not available in the clinical setting. Over…
View article: Clinical Features, Pathobiology, Efficacy, and Toxicity of Tenofovir Disoproxil Fumarate and Emtricitabine for Mild to Moderate SARS-CoV-2 Infections
Clinical Features, Pathobiology, Efficacy, and Toxicity of Tenofovir Disoproxil Fumarate and Emtricitabine for Mild to Moderate SARS-CoV-2 Infections Open
This study evaluated the efficacy of tenofovir disoproxil fumarate (TDF) and TDF combined with emtricitabine (FTC) in patients with COVID-19 infections (ClinicalTrials.gov#NCT04712357).We conducted a randomized, double-blind, placebo-contr…
View article: Modeling of post-traumatic epilepsy and experimental research aimed at its prevention
Modeling of post-traumatic epilepsy and experimental research aimed at its prevention Open
Research on the prevention of post-traumatic epilepsy (PTE) has seen remarkable advances regarding its physiopathology in recent years. From the search for biomarkers that might be used to indicate individual susceptibility to the developm…
View article: Author response for "Marmosets have a greater diversity of <scp>c‐Fos</scp> response after hyperstimulation in distinct cortical regions as compared to rats"
Author response for "Marmosets have a greater diversity of <span>c‐Fos</span> response after hyperstimulation in distinct cortical regions as compared to rats" Open
View article: Lipopolysaccharide-Induced Systemic Inflammation in the Neonatal Period Increases Microglial Density and Oxidative Stress in the Cerebellum of Adult Rats
Lipopolysaccharide-Induced Systemic Inflammation in the Neonatal Period Increases Microglial Density and Oxidative Stress in the Cerebellum of Adult Rats Open
Inflammatory processes occurring in the perinatal period may affect different brain regions, resulting in neurologic sequelae. Injection of lipopolysaccharide (LPS) at different neurodevelopmental stages produces long-term consequences in …
View article: LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats
LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats Open
Neonatal lipopolysaccharide (LPS) exposure-induced brain inflammation has been associated to neuronal injury and facilitates the development of models of neurological disorders in adult rats. The P2X7 receptor (P2X7R) plays a fundamental r…
View article: [11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive multiple sclerosis
[11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive multiple sclerosis Open
View article: The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control
The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control Open
IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT expression in neuronal cells increases basal GCN2 activation and eIF2α phosphorylatio…
View article: The Use of Biperiden as an Antiepileptogenic Drug in Patients with Moderate or Severe Traumatic Brain Injury
The Use of Biperiden as an Antiepileptogenic Drug in Patients with Moderate or Severe Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a public health problem, with considerable social and economic burden. TBI is one of the most important causes of secondary epilepsy, with a cumulative probability of 10% over a 5 years period. TBI leads to …
View article: Effects of a 7-Day Meditation Retreat on the Brain Function of Meditators and Non-Meditators During an Attention Task
Effects of a 7-Day Meditation Retreat on the Brain Function of Meditators and Non-Meditators During an Attention Task Open
Meditation as a cognitive enhancement technique is of growing interest in the field of health and research on brain function. The Stroop Word-Color Task (SWCT) has been adapted for neuroimaging studies as an interesting paradigm for the un…
View article: Interação academia-indústria. Relato da experiência da Vale
Interação academia-indústria. Relato da experiência da Vale Open
RESUMO Abordamos aqui a nucleação de um modelo de inovação aberta na Vale (uma das maiores mineradoras do mundo) apresentando o contexto histórico em que se deu esse processo. Discutimos algumas das questões que possivelmente haviam até en…
View article: Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment Open
View article: Replacement of Asymmetric Synaptic Profiles in the Molecular Layer of Dentate Gyrus Following Cycloheximide in the Pilocarpine Model in Rats
Replacement of Asymmetric Synaptic Profiles in the Molecular Layer of Dentate Gyrus Following Cycloheximide in the Pilocarpine Model in Rats Open
Mossy fiber sprouting is among the best-studied forms of post-lesional synaptic plasticity and is regarded by many as contributory to seizures in both humans and animal models of epilepsy. It is not known whether mossy fiber sprouting incr…
View article: The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys
The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys Open
Intense activation of neurons triggers the appearance of immediate expression genes, including c-Fos. This gene is related to various signal cascades involved in biochemical processes such as neuronal plasticity, cell growth and mitosis. H…
View article: Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures
Maximal electroshock-induced seizures are able to induce Homer1a mRNA expression but not pentylenetetrazole-induced seizures Open