Annouschka Laenen
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View article: Electronic Patient File‐Embedded Model‐Informed Precision Dosing Compared with Physician Dosing of Tacrolimus in Kidney Transplantation
Electronic Patient File‐Embedded Model‐Informed Precision Dosing Compared with Physician Dosing of Tacrolimus in Kidney Transplantation Open
Model‐informed precision dosing (MIPD) of tacrolimus in renal allograft recipients, evaluated in silico , demonstrated improved (time to and) probability of target concentration attainment and smaller deviations from target range. Using si…
View article: Strategy to select nasopharyngeal cancer patients for adaptive radiotherapy
Strategy to select nasopharyngeal cancer patients for adaptive radiotherapy Open
Background Nasopharyngeal cancer (NPC) patients experience significant anatomical changes during radiation treatment (RT). Adaptive radiotherapy (ART) can be initiated in response to specific events or at scheduled intervals during treatme…
View article: Transoral robotic surgery using the Da Vinci Xi: an update of a prospective outcome analysis
Transoral robotic surgery using the Da Vinci Xi: an update of a prospective outcome analysis Open
Background: The Da Vinci Xi-system is not FDA-approved for transoral robotic surgery (TORS), resulting in limited data. Methods: In this single-center prospective study, 90 head and neck cancer patients were consecutively included. The pri…
View article: Effectiveness of comprehensive geriatric assessment with extensive patient coaching for improving quality of life in older patients with solid tumours receiving systemic therapy (G-oncoCOACH): a multicentre randomised controlled trial
Effectiveness of comprehensive geriatric assessment with extensive patient coaching for improving quality of life in older patients with solid tumours receiving systemic therapy (G-oncoCOACH): a multicentre randomised controlled trial Open
Stand Up to Cancer (Kom op tegen Kanker).
View article: Optimal treatment duration in metastatic renal cell carcinoma patients responding to immune checkpoint inhibitors: should we treat beyond two years?
Optimal treatment duration in metastatic renal cell carcinoma patients responding to immune checkpoint inhibitors: should we treat beyond two years? Open
Background and purpose: Optimal treatment duration is unknown in metastatic renal cell carcinoma (mRCC) responding to immune checkpoint inhibitors (ICPIs). Prolonged treatment can lead to late toxicity, burden for day clinics and financial…
View article: Primary vs. second primary cT1-T2 oral squamous cell carcinoma: comparing the outcomes
Primary vs. second primary cT1-T2 oral squamous cell carcinoma: comparing the outcomes Open
Introduction and aim Head and neck cancer (HNC) is the third most common cancer worldwide, with oral squamous cell carcinoma (OSCC) having the highest incidence. Despite early diagnosis in 50% of cases, recurrence and poor survival remain …
View article: Diabetes Risk Perception in Women with a Recent History of Gestational Diabetes Mellitus: A Secondary Analysis from a Belgian Randomized Controlled Trial (MELINDA Study)
Diabetes Risk Perception in Women with a Recent History of Gestational Diabetes Mellitus: A Secondary Analysis from a Belgian Randomized Controlled Trial (MELINDA Study) Open
Background/Objectives: To evaluate diabetes risk perception in women with prior gestational diabetes mellitus (GDM) and prediabetes in early postpartum. Methods: Secondary analysis of a multi-center randomized controlled trial assessing th…
View article: Glucose Homeostasis, Metabolomics, and Pregnancy Outcomes After Bariatric Surgery (GLORIA): Protocol for a Multicentre Prospective Cohort Study
Glucose Homeostasis, Metabolomics, and Pregnancy Outcomes After Bariatric Surgery (GLORIA): Protocol for a Multicentre Prospective Cohort Study Open
Background: Metabolic bariatric surgery is a highly effective and long-lasting treatment for obesity and related chronic conditions. Women of reproductive age represent the largest group undergoing these procedures. Observational studies s…
View article: Mental Health and Metabolic Outcomes in Early Postpartum in Women with Prediabetes After Gestational Diabetes: A Secondary Analysis of the MELINDA Trial
Mental Health and Metabolic Outcomes in Early Postpartum in Women with Prediabetes After Gestational Diabetes: A Secondary Analysis of the MELINDA Trial Open
Aims: To examine the association between depressive symptoms and metabolic profile in women with prior gestational diabetes mellitus (GDM) and early postpartum prediabetes, and to explore whether a mobile-based lifestyle intervention affec…
View article: Women With Higher GCT Levels but NGT Have a Similarly High Risk for Glucose Intolerance Postpartum as Women With GDM
Women With Higher GCT Levels but NGT Have a Similarly High Risk for Glucose Intolerance Postpartum as Women With GDM Open
Context More data are needed on the long-term postpartum metabolic risk of women with hyperglycemia in pregnancy less than gestational diabetes mellitus (GDM) based on the 2013 World Health Organization criteria. Objective This work aimed …
View article: Clinical course and prognostic factors of patients with dedifferentiated liposarcoma: a retrospective analysis
Clinical course and prognostic factors of patients with dedifferentiated liposarcoma: a retrospective analysis Open
DDLPS is a subtype of soft tissue sarcoma with an aggressive clinical course and very poor prognosis, especially in patients with inoperable or metastatic disease. The results with classic chemotherapy are poor, and experimental treatments…
View article: Sodium Patterns and Their Variables in a Cohort of ELBW Infants in the First 10 Days of Life
Sodium Patterns and Their Variables in a Cohort of ELBW Infants in the First 10 Days of Life Open
Background: Sodium regulation is critical in extremely low-birth-weight (ELBW, <1000 g) infants. In a recent systematic review, a sodium pattern over postnatal age and its variables (care factors, fluid regimens, and maturational factors) …
View article: Sodium Patterns and Its Variables in a Cohort of Extremely Low Birth Weight Infants in the First 10 Days of Life
Sodium Patterns and Its Variables in a Cohort of Extremely Low Birth Weight Infants in the First 10 Days of Life Open
Background: Sodium regulation is critical in extremely low birth weight (ELBW, < 1000 grams) in-fants. In a recent systematic review, a sodium pattern over postnatal age and its variables (care factors, fluid regimens, maturational fact…
View article: Hypo- and Hypernatremia in Extremely Low Birth Weight Infants in the First 10 Days of Life: A Review
Hypo- and Hypernatremia in Extremely Low Birth Weight Infants in the First 10 Days of Life: A Review Open
Background/Objectives: Sodium regulation is critical in extremely low birth weight (ELBW, <1000 g) infants. This study aimed to provide a comprehensive overview of sodium dynamics and related variables in ELBW infants in their first 10 day…
View article: Mathematical Albumin Function for Neonates Undergoing Therapeutic Hypothermia in Comparison with Control Neonates
Mathematical Albumin Function for Neonates Undergoing Therapeutic Hypothermia in Comparison with Control Neonates Open
Hypoxic‐ischemic encephalopathy (HIE) resulting from perinatal asphyxia presents a substantial risk of mortality and long‐term sequelae in neonates. Therapeutic hypothermia (TH) improves both short‐ and long‐term outcomes in near‐term/term…
View article: Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study
Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study Open
Background: Breast cancer is the most common malignancy in women and the leading cause of cancer-related death. Although most early-stage patients are cured, 20% to 30% develop metastases, significantly reducing survival rates. Recent rese…
View article: Diffusion-Weighted MRI and Human Papillomavirus (HPV) Status in Oropharyngeal Cancer
Diffusion-Weighted MRI and Human Papillomavirus (HPV) Status in Oropharyngeal Cancer Open
Background: This study aimed to explore the differences in quantitative diffusion-weighted (DW) MRI parameters in oropharyngeal squamous cell carcinoma (OPC) based on Human Papillomavirus (HPV) status before and during radiotherapy (RT). M…
View article: Luteinizing hormone profiles during ovarian stimulation in assisted reproductive treatment
Luteinizing hormone profiles during ovarian stimulation in assisted reproductive treatment Open
Introduction Few data is available on the natural course of luteinizing hormone (LH) during ovarian stimulation, but it has been suggested that ‘oversuppressed’ LH could decrease fertility outcomes. Our aim with this study is to evaluate t…
View article: Late intervention for type II endoleak is not determined by early sac diameter or volume changes after EVAR
Late intervention for type II endoleak is not determined by early sac diameter or volume changes after EVAR Open
Background To compare the diagnostic accuracy and predictive value of aneurysm sac volume measurement versus maximum diameter measurement of abdominal aortic aneurysm sac after endovascular aneurysm repair (EVAR) in patients with type II e…
View article: Expression patterns of H3K27me3 for differentiation of breast fibroadenomas and phyllodes tumors
Expression patterns of H3K27me3 for differentiation of breast fibroadenomas and phyllodes tumors Open
Phyllodes tumors (PTs) are rare breast tumors showing overlapping features with fibroadenomas (FAs). Diagnosis on small biopsies is challenging. New diagnostic markers are needed. Here we evaluated immunohistochemical staining of histone 3…
View article: Human serum albumin: prediction model and reference values for preterm and term neonates
Human serum albumin: prediction model and reference values for preterm and term neonates Open
Background Human serum albumin (HSA) concentrations may alter HSA-bound drug distribution. This study aims to describe longitudinal real-world HSA trends, and to develop a prediction model for HSA concentrations using a large neonatal coho…