Elizabeth R. Lawlor
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View article: Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase
Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase Open
Epigenetic dysregulation is a hallmark of cancer. Small molecule inhibitors such as bromodomain and extraterminal (BET) protein inhibitors developed to target epigenetic dependencies have demonstrated significant promise in preclinical mod…
View article: Advancing Preclinical Biology for Ewing Sarcoma: An International Effort
Advancing Preclinical Biology for Ewing Sarcoma: An International Effort Open
Ewing sarcoma is an aggressive bone and soft-tissue cancer affecting adolescents and young adults. In vitro and in vivo models of Ewing sarcoma have been instrumental in advancing our understanding of Ewing sarcoma biology and essential in…
View article: New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee
New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee Open
Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New S…
View article: Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma Open
Ewing sarcoma (EwS) is a fusion-driven malignancy, peaking in adolescence. Although EwS tumors are driven uniquely by EWS::FLI1 and related fusions, patient outcomes vary greatly. If and how tumor plasticity of EWS::FLI1-regulated transcri…
View article: Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma Open
Sub-populations of cancer-associated fibroblast (CAF)-like tumor cells deposit extracellular matrix (ECM) proteins that support Ewing sarcoma (EwS) progression and metastasis. We previously showed a hallmark of CAF-like EwS cells is their …
View article: Determining preclinical safety of Aclarubicin in pediatric malignancies
Determining preclinical safety of Aclarubicin in pediatric malignancies Open
Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose-dependent toxicities, particularly cardiotoxicity and secondary malignancie…
View article: Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children’s Oncology Group Bone Tumor Committee Consensus Statement
Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children’s Oncology Group Bone Tumor Committee Consensus Statement Open
Trends in diagnostic biopsy sample collection approaches for primary bone sarcomas have shifted in the past 2 decades. Although open/incisional biopsies used to be the predominant approach to obtain diagnostic material for Ewing sarcoma an…
View article: Supplemental Figure S3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S3. Spatial heterogeneity of CD73+ tumor cells and ECM deposition in additional xenograft and PDX-derived models. Related to Figure 3.
View article: Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 6. List of genes that positively correlate with NT5E expression in 3 independent patient tumor cohorts.
View article: Supplementary Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
Supplementary Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer Open
Supplementary Table 1: NCI-H295R RNA-seq FPKM table, Related to Figures 2-4, 6.
View article: Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 7. Clinical information and CD73 IHC score for patient tumor tissue microarray.
View article: Supplementary Information from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
Supplementary Information from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer Open
Supplementary Information: Supplementary Figures 1-6 with Figure Legends, Supplementary Table 1 (reference only), Supplementary Table 2, Supplementary Methods, Supplementary References
View article: Supplementary Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
Supplementary Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer Open
Supplementary Table 1: NCI-H295R RNA-seq FPKM table, Related to Figures 2-4, 6.
View article: Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S1. CD73+ EwS cells retain proliferative and tumorigenic capacity. Related to Figure 1.
View article: Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 5. Q3 normalized gene expression counts for CHLA10 xenograft digital spatial profiling.
View article: Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer Open
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC…
View article: Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 2. 52 genes overlapping between markers of cells with high GO:BP Mesenchymal Development from A673 and CHLA10 single cell sequencing and EWS::FLI1 repressed gene set.
View article: Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S1. CD73+ EwS cells retain proliferative and tumorigenic capacity. Related to Figure 1.
View article: Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 7. Clinical information and CD73 IHC score for patient tumor tissue microarray.
View article: Supplemental Table 3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Table 3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 3. RNAseq-derived gene expression data for CD73- and CD73+ A673 and CHLA10 cells.
View article: Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 2. 52 genes overlapping between markers of cells with high GO:BP Mesenchymal Development from A673 and CHLA10 single cell sequencing and EWS::FLI1 repressed gene set.
View article: Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S5. Patient tumor gene expression microarrays display heterogeneity of expression of NT5E and associated mesenchymal gene signature. Related to Figure 5.
View article: Supplemental Figure S2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S2. CD73+ cells are enriched in EMT and ECM gene expression. Related to Figure 2.
View article: Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S5. Patient tumor gene expression microarrays display heterogeneity of expression of NT5E and associated mesenchymal gene signature. Related to Figure 5.
View article: Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S6. Intertumoral heterogeneity of CD73+ tumor cells and ECM deposition in patient biopsies. Related to Figure 6.
View article: Supplementary Table 1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 1. Table of selected reagents and resources used.
View article: Data from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Data from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Purpose: Despite limited genetic and histologic heterogeneity, Ewing sarcoma (EwS) tumor cells are transcriptionally heterogeneous and display varying degrees of mesenchymal lineage specification in vitro. In this study, we investigated if…
View article: Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 5. Q3 normalized gene expression counts for CHLA10 xenograft digital spatial profiling.
View article: Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S6. Intertumoral heterogeneity of CD73+ tumor cells and ECM deposition in patient biopsies. Related to Figure 6.
View article: Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 6. List of genes that positively correlate with NT5E expression in 3 independent patient tumor cohorts.