Adeera Levin
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View article: Association between COVID-19 vaccination, SARS-CoV-2 variants, and post COVID-19 condition: A cross-sectional study
Association between COVID-19 vaccination, SARS-CoV-2 variants, and post COVID-19 condition: A cross-sectional study Open
Background Individuals may experience persistent symptoms after recovering from coronavirus disease 2019 (COVID-19), a condition referred to as post COVID-19 condition (PCC). Patient-reported outcome measures (PROMs) evaluate a patient’s h…
View article: Outcomes of Patients With Autosomal Dominant Polycystic Kidney Disease Prescribed SGLT2 Inhibitors in British Columbia: A Single-Arm Retrospective Cohort Study
Outcomes of Patients With Autosomal Dominant Polycystic Kidney Disease Prescribed SGLT2 Inhibitors in British Columbia: A Single-Arm Retrospective Cohort Study Open
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the fourth leading cause of kidney failure in Canada and internationally. To date, patients with ADPKD have been excluded from trials of sodium-glucose cotransporter type …
View article: Sodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD
Sodium-Glucose Cotransporter 2 Inhibition and Hospitalizations in Patients with CKD Open
Key Points In this post hoc analysis of Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation, canagliflozin reduced the risk of first and subsequent all-cause hospitalization by 14%. Sodium-glucose co…
View article: Long-Term Outcomes of COVID-19 in Patients Receiving Maintenance Dialysis
Long-Term Outcomes of COVID-19 in Patients Receiving Maintenance Dialysis Open
Key Points In maintenance dialysis patients, 90-day coronavirus disease 2019 (COVID-19) survivors did not have a higher long-term risk of death or adverse health outcomes. Prior COVID-19 infection was associated with a lower risk for subse…
View article: Rationale and Design of the International Prospective Study of CKD of Uncertain Etiology in Agricultural Communities
Rationale and Design of the International Prospective Study of CKD of Uncertain Etiology in Agricultural Communities Open
This study will provide novel information about CKDu etiology and clinical phenotypes across distinct geographies.
View article: Front Cover
Front Cover Open
The cover image is based on the article The interplay between heart failure and chronic kidney disease by Anuradha Lala MD et al., https://doi.org/10.1111/dom.16371 . image
View article: The interplay between heart failure and chronic kidney disease
The interplay between heart failure and chronic kidney disease Open
Chronic kidney disease (CKD) and heart failure (HF) are two globally prevalent, independent, long‐term conditions, which often coexist in an individual and display a bidirectional yet interconnected relationship. The presence of CKD often …
View article: Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD
Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD Open
Key Points In patients with CKD, non- DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) was associated with higher risk of cardiovascular events. There was no significant difference in the CHIP–cardiovascular disease associatio…
View article: Clonal Hematopoiesis of Indeterminate Potential and Progression of CKD
Clonal Hematopoiesis of Indeterminate Potential and Progression of CKD Open
Key Points Non- DNMT3A clonal hematopoiesis of indeterminate potential was associated with CKD progression in a meta-analysis of 5654 individuals with CKD. In an adenine-induced CKD mouse model, Tet2 -clonal hematopoiesis of indeterminate …
View article: Safety and Effectiveness of Apixaban versus Warfarin by Kidney Function in Atrial Fibrillation
Safety and Effectiveness of Apixaban versus Warfarin by Kidney Function in Atrial Fibrillation Open
Key Points This real-world study involved a large cohort of 38,598 adults with atrial fibrillation from five jurisdictions across Australia and Canada. This study supports the use of apixaban as a safe and effective alternative to warfarin…
View article: MyGuide long COVID: An online self-management tool for people with long COVID
MyGuide long COVID: An online self-management tool for people with long COVID Open
An online tool to support chronic disease self-management can be successfully co-developed with patient partners and engagement tracked using web analytics.
View article: A Province-Wide Home Dialysis Program Review: Challenges, Strengths, and Future Strategies
A Province-Wide Home Dialysis Program Review: Challenges, Strengths, and Future Strategies Open
Purpose of review: British Columbia (BC) has a robust provincial kidney care program emphasizing patient-centered and goal-oriented dialysis care. Despite maintaining a home dialysis prevalence of approximately 30%, consistently above the …
View article: Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA
Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA Open
A core feature of universal health coverage is equitable access to affordable care not exposing people to financial hardship. This study aims to provide a global overview on availability and access to medications and health technologies fo…
View article: Cardiovascular, kidney and safety outcomes with canagliflozin in older adults: A combined analysis from the <scp>CANVAS</scp> Program and <scp>CREDENCE</scp> trial
Cardiovascular, kidney and safety outcomes with canagliflozin in older adults: A combined analysis from the <span>CANVAS</span> Program and <span>CREDENCE</span> trial Open
Aim SGLT2 inhibitors may be underused in older adults with type 2 diabetes due to concerns about safety and tolerability. This pooled analysis of the CANVAS Program and CREDENCE trial examined the efficacy and safety of canagliflozin accor…
View article: Regional hotspots for chronic kidney disease: A multinational study from the ISN-GKHA
Regional hotspots for chronic kidney disease: A multinational study from the ISN-GKHA Open
Chronic kidney disease (CKD) disproportionately affects certain populations as demonstrated by well-established subnational geographic hotspots of CKD in Central America and South Asia. Using data from the third iteration of the Internatio…
View article: Landscape of kidney replacement therapy provision in low- and lower-middle income countries: A multinational study from the ISN-GKHA
Landscape of kidney replacement therapy provision in low- and lower-middle income countries: A multinational study from the ISN-GKHA Open
In low- and lower-middle-income countries (LLMICs), delivering equitable kidney care presents substantial challenges, resulting in significant disparities in disease management and treatment outcomes for people with kidney failure. This co…
View article: Global Policy and Advocacy Initiatives for Improving Kidney Care
Global Policy and Advocacy Initiatives for Improving Kidney Care Open
Key Points Inclusion and prioritization of CKD and kidney failure within national health strategies are generally lacking. Countries with CKD-specific strategies tend to include and fund a broader spectrum of kidney disease populations and…
View article: A global snapshot on health systems capacity for detection, monitoring, and management of acute kidney injury: A multinational study from the ISN-GKHA
A global snapshot on health systems capacity for detection, monitoring, and management of acute kidney injury: A multinational study from the ISN-GKHA Open
Acute kidney injury (AKI) is a significant cause of morbidity and mortality, especially in low and lower-middle income countries. Data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA…
View article: Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries
Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries Open
Objective To assess changes in key measures of kidney care using data reported in 2019 and 2023. Design Cross sectional survey in 148 countries. Setting Surveys from International Society of Nephrology Global Kidney Health Atlas between 20…
View article: Study Design and Baseline Characteristics of ALIGN, a Randomized Controlled Study of Atrasentan in Patients With IgA Nephropathy
Study Design and Baseline Characteristics of ALIGN, a Randomized Controlled Study of Atrasentan in Patients With IgA Nephropathy Open
The ongoing ALIGN trial evaluates the efficacy and safety of atrasentan in a representative global IgAN population at risk for disease progression despite optimized RAS inhibitor therapy and includes an exploratory stratum evaluating atras…
View article: Global data monitoring systems and early identification for kidney diseases
Global data monitoring systems and early identification for kidney diseases Open
Background Data monitoring and surveillance systems are the cornerstone for governance and regulation, planning, and policy development for chronic disease care. Our study aims to evaluate health systems capacity for data monitoring and su…
View article: Patient screening and assessment for home dialysis therapies: A scoping review
Patient screening and assessment for home dialysis therapies: A scoping review Open
Background Home dialysis therapies have limited uptake in most regions despite recognized benefits such as increasing patients’ independence, and several domains of quality of life with cost savings in some systems. Objective To perform a …