Edward A. Levine
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The Genomic Topography of Appendiceal Cancers: Our Current Understanding, Clinical Perspectives, and Future Directions Open
Background/Objectives: Appendiceal cancer (AC) is a rare and understudied malignancy with limited genomic data available to guide clinical interventions. Historically treated as a subtype of colorectal cancer, AC is now recognized as a dis…
View article: Peritonectomy procedures for peritoneal surface malignancies: PSOGI-ESGO-ISSPP Lyon consensus
Peritonectomy procedures for peritoneal surface malignancies: PSOGI-ESGO-ISSPP Lyon consensus Open
Background The nomenclature and execution of peritonectomy procedures for peritoneal surface malignancies significantly vary between surgeons and centres. The aim of this consensus was to reach uniform nomenclature for peritonectomy proced…
View article: Guidelines for the Prophylaxis and Treatment of Peritoneal Metastases From Colorectal Cancer: A GRADE‐Approach for Evidence Evaluation and Recommendations
Guidelines for the Prophylaxis and Treatment of Peritoneal Metastases From Colorectal Cancer: A GRADE‐Approach for Evidence Evaluation and Recommendations Open
Colorectal peritoneal metastases (CPM) are common in colorectal cancer patients. This article aims to provide GRADE guidelines for the use of hyperthermic intraperitoneal chemotherapy (HIPEC) in two clinical situations: (1) To determine th…
View article: Correlation of Morphological Appearance of Peritoneal Lesions at Laparotomy and Disease at Pathological Assessment in Patients Undergoing Cytoreductive Surgery for Peritoneal Malignancy: Results of Phase I of the PRECINCT Study in 707 Patients
Correlation of Morphological Appearance of Peritoneal Lesions at Laparotomy and Disease at Pathological Assessment in Patients Undergoing Cytoreductive Surgery for Peritoneal Malignancy: Results of Phase I of the PRECINCT Study in 707 Patients Open
Background The PRECINCT (Pattern of peritoneal dissemination and REsponse to systemic Chemotherapy IN Common and uncommon peritoneal Tumors) is a prospective, multicenter, observational study. This report from phase I of PRECINCT outlines …
Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer Open
Introduction Appendiceal cancer (AC) excessive mucin production is a barrier to heated intraperitoneal chemotherapy (HIPEC) drug delivery. Bromelain is a pineapple stem extract with mucolytic properties. We explored bromelain treatment eff…
View article: Management of Peritoneal Surface Malignancies. (Cytoreductive Surgery, HIPEC, PIPAC, and Beyond)
Management of Peritoneal Surface Malignancies. (Cytoreductive Surgery, HIPEC, PIPAC, and Beyond) Open
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Figure S1 from Neoadjuvant Chemotherapy Shifts Breast Tumor Microbiota Populations to Regulate Drug Responsiveness and the Development of Metastasis Open
Obesity influences breast tumor microbiota populations. Breast tumor 16S sequencing results were stratified based upon patient body mass index (BMI). Tumor bacterial populations from non-obese patients with a BMI of 20-27 (n=9) were compar…
Data from Neoadjuvant Chemotherapy Shifts Breast Tumor Microbiota Populations to Regulate Drug Responsiveness and the Development of Metastasis Open
Breast tumors have their own specific microbiota, distinct from normal mammary gland tissue. Patients with breast cancer that present with locally advanced disease often undergo neoadjuvant chemotherapy to reduce tumor size prior to surger…
Figure S1 from Neoadjuvant Chemotherapy Shifts Breast Tumor Microbiota Populations to Regulate Drug Responsiveness and the Development of Metastasis Open
Obesity influences breast tumor microbiota populations. Breast tumor 16S sequencing results were stratified based upon patient body mass index (BMI). Tumor bacterial populations from non-obese patients with a BMI of 20-27 (n=9) were compar…
Data from Neoadjuvant Chemotherapy Shifts Breast Tumor Microbiota Populations to Regulate Drug Responsiveness and the Development of Metastasis Open
Breast tumors have their own specific microbiota, distinct from normal mammary gland tissue. Patients with breast cancer that present with locally advanced disease often undergo neoadjuvant chemotherapy to reduce tumor size prior to surger…
Figure S3 from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
Effect of PUFA on apical polarity in S1 acini. S1 cells cultured in 3D were treated following differentiation (days 8-12) with 10 μM of n-6 arachidonic acid (AA) or with vehicle (ethanol). (A) Representative confocal images of acini treate…
Supplementary Figure 1 from Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study Open
Flow cytometry analysis of CD8+ T-cells after co-culture with tumor cells in organoids for 1 week.
Figure S2 from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
A. Uninfected 4T1 tumor volume from mice treated 1 x weekly control diet-derived fecal transplant. B. Uninfected 4T1 tumor volume from mice treated 1 x weekly lard diet-derived fecal transplant. C. Tumor volume over time of uninfected 4T1 …
Figure S1 from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
BALB/c DMBA tumors were stained against Ki67 (A) and F4/80 (B) to determine effects of diet and microbiota on primary tumor proliferation and tumor-associated macrophage populations.
Data from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
Obesity and poor diet often go hand-in-hand, altering metabolic signaling and thereby impacting breast cancer risk and outcomes. We have recently demonstrated that dietary patterns modulate mammary microbiota populations. An important and …
Figure S1 from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
BALB/c DMBA tumors were stained against Ki67 (A) and F4/80 (B) to determine effects of diet and microbiota on primary tumor proliferation and tumor-associated macrophage populations.
Figure S3 from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
Effect of PUFA on apical polarity in S1 acini. S1 cells cultured in 3D were treated following differentiation (days 8-12) with 10 μM of n-6 arachidonic acid (AA) or with vehicle (ethanol). (A) Representative confocal images of acini treate…
Data from Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study Open
Purpose:Immunotherapy efficacy data on appendiceal cancer from clinical trials does not exist, due to appendiceal cancer incidence of 0.97 per 100,000. The goal of this study was to preclinically explore the application of immunotherapy in…
Figure S2 from Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis Open
A. Uninfected 4T1 tumor volume from mice treated 1 x weekly control diet-derived fecal transplant. B. Uninfected 4T1 tumor volume from mice treated 1 x weekly lard diet-derived fecal transplant. C. Tumor volume over time of uninfected 4T1 …
Supplementary Figure 1 from Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study Open
Flow cytometry analysis of CD8+ T-cells after co-culture with tumor cells in organoids for 1 week.