Michael Gertz
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View article: The association of climate-induced stressors on risk of negative sentiment: An analysis from 462 million geotagged tweets in Europe
The association of climate-induced stressors on risk of negative sentiment: An analysis from 462 million geotagged tweets in Europe Open
Summary: This study examines how climate-induced health risks influence negative sentiments on European social tweets from 2015 to 2022. Analyzing over 400 million tweets using NLP tools (NLTK, LIWC22) and spatial-temporal aggregation at t…
View article: Long-read sequencing of single cell-derived melanoma subclones reveals divergent and parallel genomic and epigenomic evolutionary trajectories
Long-read sequencing of single cell-derived melanoma subclones reveals divergent and parallel genomic and epigenomic evolutionary trajectories Open
Tumor evolution is driven by various mutational processes, ranging from single-nucleotide vari- ants (SNVs) to large structural variants (SVs) to dynamic shifts in DNA methylation. Current short-read sequencing methods struggle to accurate…
View article: ClusterChat: Multi-Feature Search for Corpus Exploration
ClusterChat: Multi-Feature Search for Corpus Exploration Open
View article: heiDS at ArchEHR-QA 2025: From Fixed-k to Query-dependent-k for Retrieval Augmented Generation
heiDS at ArchEHR-QA 2025: From Fixed-k to Query-dependent-k for Retrieval Augmented Generation Open
This paper presents the approach of our team called heiDS for the ArchEHR-QA 2025 shared task. A pipeline using a retrieval augmented generation (RAG) framework is designed to generate answers that are attributed to clinical evidence from …
View article: Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases
Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases Open
This study extends our understanding of the ocular pharmacokinetics and pharmacodynamics of ranibizumab and provides theoretical insights for enhanced data collection schemes to be considered for clinical trials and in the development of n…
View article: Publisher Correction: Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data
Publisher Correction: Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data Open
View article: Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data
Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data Open
During drug development, the design, interpretation and risk assessment of drug-drug interaction (DDI) are generally performed with physiologically-based pharmacokinetic (PBPK) modelling. Critical parameters are the hepatic metabolic fract…
View article: The impact of climatic factors on negative sentiments: An analysis of human expressions from X platform in Germany
The impact of climatic factors on negative sentiments: An analysis of human expressions from X platform in Germany Open
View article: heiDS at ArchEHR-QA 2025: From Fixed-k to Query-dependent-k for Retrieval Augmented Generation
heiDS at ArchEHR-QA 2025: From Fixed-k to Query-dependent-k for Retrieval Augmented Generation Open
View article: The Association of Climate-Induced Stressors on Negative Sentiment Risk: An Analysis from 462 Million Geotagged Tweets in Europe
The Association of Climate-Induced Stressors on Negative Sentiment Risk: An Analysis from 462 Million Geotagged Tweets in Europe Open
View article: ClusterChat: Multi-Feature Search for Corpus Exploration
ClusterChat: Multi-Feature Search for Corpus Exploration Open
Exploring large-scale text corpora presents a significant challenge in biomedical, finance, and legal domains, where vast amounts of documents are continuously published. Traditional search methods, such as keyword-based search, often retr…
View article: A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location
A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location Open
The modeling results suggest that experimental variability in ocular half-life is partially attributed to anatomical differences and injection site location. Simulations further suggest a potential role of the posterior pathway permeabilit…
View article: Establishing Medical Intelligence—Leveraging Fast Healthcare Interoperability Resources to Improve Clinical Management: Retrospective Cohort and Clinical Implementation Study
Establishing Medical Intelligence—Leveraging Fast Healthcare Interoperability Resources to Improve Clinical Management: Retrospective Cohort and Clinical Implementation Study Open
Background FHIR (Fast Healthcare Interoperability Resources) has been proposed to enable health data interoperability. So far, its applicability has been demonstrated for selected research projects with limited data. Objective This study a…
View article: Numbers Matter! Bringing Quantity-awareness to Retrieval Systems
Numbers Matter! Bringing Quantity-awareness to Retrieval Systems Open
Quantitative information plays a crucial role in understanding and interpreting the content of documents. Many user queries contain quantities and cannot be resolved without understanding their semantics, e.g., ``car that costs less than $…
View article: A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location
A first passage model of intravitreal drug delivery and residence time, in relation to ocular geometry, individual variability, and injection location Open
Purpose: Standard of care for various retinal diseases involves recurrent intravitreal injections. This motivates mathematical modelling efforts to identify influential factors for drug residence time, aiming to minimise administration fre…
View article: LexDrafter: Terminology Drafting for Legislative Documents using Retrieval Augmented Generation
LexDrafter: Terminology Drafting for Legislative Documents using Retrieval Augmented Generation Open
With the increase in legislative documents at the EU, the number of new terms and their definitions is increasing as well. As per the Joint Practical Guide of the European Parliament, the Council and the Commission, terms used in legal doc…
View article: In silico modeling and simulation of organ‐on‐a‐chip systems to support data analysis and a priori experimental design
In silico modeling and simulation of organ‐on‐a‐chip systems to support data analysis and a priori experimental design Open
Organ‐on‐a‐chip (OoC) systems are a promising new class of in vitro devices that can combine various tissues, cultured in different compartments, linked by media flow. The properties of these novel in vitro systems linked to increased phys…
View article: Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas
Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas Open
The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers, a phenomenon that has been investigated without resolution since the late 1980s. Expanding beyond …
View article: The Impact of Climate on Negative Sentiments: An Analysis of Human Expressions on the X Platform in Germany
The Impact of Climate on Negative Sentiments: An Analysis of Human Expressions on the X Platform in Germany Open
View article: TrendTracker: Temporal, network-based exploration of long-term Twitter trends
TrendTracker: Temporal, network-based exploration of long-term Twitter trends Open
TrendTracker is a web application for the network-based and temporal exploration of long-term social media trends. Topical trends, represented as a series of hashtag co-occurrence networks, can interactively be explored while the user is p…
View article: CODY: A graph-based framework for the analysis of COnversation DYnamics in online social networks
CODY: A graph-based framework for the analysis of COnversation DYnamics in online social networks Open
Conversations are an integral part of online social media, and gaining insights into these conversations is of significant value for many commercial as well as academic use cases. From a computational perspective, however, analyzing conver…
View article: A network approach to atomic spectra
A network approach to atomic spectra Open
Network science provides a universal framework for modeling complex systems, contrasting the reductionist approach generally adopted in physics. In a prototypical study, we utilize network models created from spectroscopic data of atoms to…
View article: Who Is behind a Trend? Temporal Analysis of Interactions among Trend Participants on Twitter
Who Is behind a Trend? Temporal Analysis of Interactions among Trend Participants on Twitter Open
Trends are a fundamental component of today's fast-evolving media landscape. Still, a lot of questions about who participates in such trends remain unanswered. Are trends driven by individual actors, or do interactions between actors revea…
View article: Evaluating Factual Consistency of Texts with Semantic Role Labeling
Evaluating Factual Consistency of Texts with Semantic Role Labeling Open
Automated evaluation of text generation systems has recently seen increasing attention, particularly checking whether generated text stays truthful to input sources. Existing methods frequently rely on an evaluation using task-specific lan…
View article: CQE: A Comprehensive Quantity Extractor
CQE: A Comprehensive Quantity Extractor Open
Quantities are essential in documents to describe factual information. They are ubiquitous in application domains such as finance, business, medicine, and science in general. Compared to other information extraction approaches, interesting…
View article: Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children
Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children Open
View article: Investigation of simplified physiologically‐based pharmacokinetic models in rat and human
Investigation of simplified physiologically‐based pharmacokinetic models in rat and human Open
Whole‐body physiologically‐based pharmacokinetic (PBPK) models have many applications in drug research and development. It is often necessary to inform these models with animal or clinical data, updating model parameters, and making the mo…
View article: A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models
A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models Open
Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to in vivo pharmacokinetic (PK) data. After optimization wit…
View article: On the State of German (Abstractive) Text Summarization
On the State of German (Abstractive) Text Summarization Open
With recent advancements in the area of Natural Language Processing, the focus is slowly shifting from a purely English-centric view towards more language-specific solutions, including German. Especially practical for businesses to analyze…
View article: UniHD at TSAR-2022 Shared Task: Is Compute All We Need for Lexical Simplification?
UniHD at TSAR-2022 Shared Task: Is Compute All We Need for Lexical Simplification? Open
Previous state-of-the-art models for lexical simplification consist of complex pipelines with several components, each of which requires deep technical knowledge and fine-tuned interaction to achieve its full potential. As an alternative, …