Richard Moreau
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View article: Serum Villin‐1—A Novel Marker of Gut Barrier Damage in Acutely Decompensated Cirrhosis: A Cohort Study and Validation
Serum Villin‐1—A Novel Marker of Gut Barrier Damage in Acutely Decompensated Cirrhosis: A Cohort Study and Validation Open
Background Gut barrier dysfunction contributes to acute decompensation (AD) of cirrhosis progression but, it is not acknowledged in severity or prognostic scores due to a lack of appropriate assessment tools. Aim We investigated serum vill…
View article: The burden of extrahepatic organ failures in European patients with cirrhosis
The burden of extrahepatic organ failures in European patients with cirrhosis Open
Background: The impact of acute-on-chronic liver failure (ACLF), a deadly form of decompensated cirrhosis characterized by the presence of organ failures, has not been well characterized, largely due to the lack of a code for ACLF in the I…
View article: Linear ubiquitin chain assembly complex contributes to NLRP3-mediated pyroptotic cell death
Linear ubiquitin chain assembly complex contributes to NLRP3-mediated pyroptotic cell death Open
Activation of the NLRP3 inflammasome by infectious or sterile insults culminates in pyroptosis, a lytic and highly inflammatory form of programmed cell death. A safeguarded two-step process tightly regulates pyroptosis: priming, which driv…
View article: Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface
Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface Open
While locating in different microenvironments, glioblastoma stem-like cells (GSCs) receive maintenance signals and information to exploit neurovascular tracts. Although the cell adhesion mechanisms to blood vessels have been explored, the …
View article: Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies Open
Background Acute-on-chronic liver failure (ACLF) of various aetiologies is a complex syndrome with high short-term mortality and significant global burden. Objective To explore easily applicable diagnostic criteria and an accurate prognost…
View article: The Vasopressin Biomarker Copeptin Is Linked to Systemic Inflammation and Refines Prognostication in Decompensated Cirrhosis
The Vasopressin Biomarker Copeptin Is Linked to Systemic Inflammation and Refines Prognostication in Decompensated Cirrhosis Open
In patients with dACLD, copeptin is independently linked to systemic inflammation. The MELD-copeptin score identifies patients with dACLD at risk for impaired clinical outcomes.
View article: Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults
Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults Open
Background. Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the ser…
View article: Hyperammonemia induces programmed liver cell death
Hyperammonemia induces programmed liver cell death Open
Hyperammonemia is common in liver cirrhosis and causally associated with hepatic encephalopathy development. Little is known about its hepatotoxic effects, which we aimed to characterize in this study. In a mouse model of chronic hyperammo…
View article: Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis Open
Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI is a driver of the most severe forms of ADC, including acute-on-chronic liver failure (ACLF). Blood bioma…
View article: Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failure
Single-cell profiling reveals monocyte mitochondrial dysfunction in patients with cirrhosis progressing to acute-on-chronic liver failure Open
Patients with acute decompensation (AD) of cirrhosis face a high risk of acute-on-chronic liver failure (ACLF), a syndrome linked to multiple organ failure and high mortality. This study analyzed peripheral blood mononuclear cells (PBMCs) …
View article: Monitoring concentration and lipid signature of plasma extracellular vesicles from HR<sup>+</sup> metastatic breast cancer patients under CDK4/6 inhibitors treatment
Monitoring concentration and lipid signature of plasma extracellular vesicles from HR<sup>+</sup> metastatic breast cancer patients under CDK4/6 inhibitors treatment Open
Extracellular vesicles (EVs) are cell‐derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer therapies. This study aimed to comprehensive…
View article: Blood markers for type-1, -2, and -3 inflammation are associated with severity of acutely decompensated cirrhosis
Blood markers for type-1, -2, and -3 inflammation are associated with severity of acutely decompensated cirrhosis Open
This study reveals that among patients with acutely decompensated cirrhosis, alterations in blood levels of cytokines related to type-1, type-2 and type-3 inflammation, together with neutrophilia, lymphopenia and elevated anti-inflammatory…
View article: Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure
Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure Open
Background and Aims: Acute-on-chronic liver failure (ACLF) is a complication of cirrhosis characterized by multiple organ failure and high short-term mortality. The pathophysiology of ACLF involves elevated systemic inflammation leading to…
View article: ClustALL: A robust clustering strategy for stratification of patients with acutely decompensated cirrhosis
ClustALL: A robust clustering strategy for stratification of patients with acutely decompensated cirrhosis Open
Patient heterogeneity represents a significant challenge for both individual patient management and clinical trial design, especially in the context of complex diseases. Most existing clinical classifications are based on scores built to p…
View article: Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure
Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure Open
This narrative review addresses the definition of acute‐on‐chronic liver failure, a condition associated with high short‐term mortality in patients with chronic liver disease and/or cirrhosis. We provide two major points of view: the East …
View article: Acute-on-chronic liver failure: far to go—a review
Acute-on-chronic liver failure: far to go—a review Open
Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and is characterized by organ failure and high short-term mortality. Heterogeneous definition…
View article: Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure
Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure Open
Acute-on-chronic liver failure (ACLF) is the most severe form of acutely decompensated cirrhosis and is characterised by the presence of one or more organ failures, intense systemic inflammation, peripheral blood lymphopenia, and a high ri…
View article: Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America
Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America Open
Three hundred ninety-five patients (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had a higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without AC…