Enrique Bernal
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Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study “No One Alone-Gesida Study” Open
Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation – loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic inf…
View article: Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024
Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024 Open
Oropouche fever is a vector-borne disease endemic in Central and South America. Infection with Oropouche virus (OROV) was confirmed in June and July 2024 in 13 patients travelling from Cuba to Spain. These patients presented fever, headach…
Adoption of Online Business Platform Among Small and Medium Enterprises (SMEs) in the Tourism Industry in Muscat, Sultanate of Oman and Bicol Region, Philippines Open
The sustained agility of the business organization to creatively innovate and adapt to the changing business environment is a strong determinant of sustainability. This study looks into how the SMEs in tourism industry in Muscat, Oman, and…
Subcutaneous injections of cabotegravir plus rilpivirine long-acting in virally suppressed adults with HIV-1 Open
Objective: To evaluate subcutaneous anterior abdominal injections of long-acting cabotegravir plus rilpivirine (CAB + RPV LA) in participants with more than 3 years’ experience with intramuscular injections in the Phase 3 FLAIR (NCT0293852…
Simultaneous study of cochleotoxicity and vestibulotoxicity of 3,3’- iminodipropionitrile in rats through several experimental approaches Open
Many industrial chemicals and clinical compounds are toxic to the inner ear. Some preferentially target the cochlea or vestibular structures, whereas others are harmful to both. The reasons behind these distinct ototoxic profiles remain po…
Framework for approaching federated causal inference based on real-world observational data sources Open
Context Causal inference methods, generally requiring detailed individual information, allow us to evaluate public health interventions in real-world observational settings. When comparing interventions across borders and for this purpose …
Artificial urinary sphincter and stricture disease: surgical principles in management Open
Iatrogenic stress urinary incontinence (SUI) is the most common complication of surgical treatment of prostate cancer, regardless of operative approach, and has a major impact on patients' quality of life. Although SUI can occur after surg…
View article: Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV
Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV Open
We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The…
Modelling the effects of forest use change on brownification of Finnish rivers under pressures of acidification and climate change Open
Browning of surface waters due to increased terrestrial loading of dissolved organic matter is observed across the Northern Hemisphere. Brownification directly influences freshwater productivity and ecosystem services like water purificati…
View article: Clinical and Epidemiological Characteristics of the 2022 Mpox Outbreak in Spain (CEME-22 Study)
Clinical and Epidemiological Characteristics of the 2022 Mpox Outbreak in Spain (CEME-22 Study) Open
Background We conducted a multicentric national study (SEIMC-CEME-22), to describe the clinical and epidemiological profile of the mpox outbreak in Spain, including the management of the disease. Methods This was a retrospective national o…
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2 Open
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9…
View article: Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study
Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study Open
Background We compared proportions of participants with target detected, target not detected (TND), and elevated viral load (VL) and assessed baseline variables associated with week 144 inflammatory biomarker levels between dolutegravir-la…
View article: IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors
IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors Open
Background Interferon-inducible protein-10 (IP-10) and monokine induced by interferon-gamma (MIG) are chemokines recognized as inflammatory biomarkers during HIV-1 infection. We assessed their early and long-term dynamics after initiation …
Failure of Non-Invasive Respiratory Support in Patients with SARS-CoV-2 Open
Introduction: The objective of this study is to assess the failure of therapies with HFNO (high-flow nasal oxygen), CPAP, Bilevel, or combined therapy in patients with hypoxemic acute respiratory failure due to SARS-CoV-2 during their hosp…
Trends in mental health diagnosis and use of resources in Europe during the COVID-19 pandemic Open
Background The European Population Health Information Research Infraestructure (PHIRI) conducted research through use cases of applicability for public health policies during the COVID-19 pandemic. The aim of this study is to present chang…
Framework for federated causal inference based on real-world observational data sources (BY-COVID) Open
Background Causal inference techniques help researchers and policy-makers to evaluate public health interventions. Approaching causal inference by re-using routinely collected observational data across different regions is challenging and …
Failure of Non-invasive Respiratory Support in Patients with SARS-Cov-2 with the Different Therapies Open
Introduction: The objective of the study is to assess the failure of therapies with HFNO (High-Flow Nasal Oxygen), CPAP, Bilevel or combined therapy in patients with hypoxemic acute respiratory failure due to SARS-CoV-2 during their hospit…
Effects of water chemistry, land use and climate change on waterbirds in a boreal lake complex Open
Brownification of freshwater is a global issue with many implications. The high accumulation of organic matter causing the darkening of freshwater is explained by numerous factors including climate and land use. One example of this alterat…
View article: Correction: Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection
Correction: Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection Open
Background: The incidence of non-AIDS defining cancer (NADC) is higher in people living with HIV (PLWH) than in the general population, and it is already one of the leading causes of death in the HIV-infected population.It is estimated tha…
View article: Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens
Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens Open
Objectives To evaluate the efficacy and safety of the two-pill regimen bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat as a switching strategy in heavily treatment-experienced people living with HIV …
Low‐level HIV viraemia during antiretroviral therapy: Longitudinal patterns and predictors of viral suppression Open
Objectives Our objective was to characterize longitudinal patterns of viraemia and factors associated with viral suppression in people with HIV and low‐level viraemia (LLV) during antiretroviral therapy (ART). Methods We included people wi…
Developing and testing a protocol using a common data model for federated collection and analysis of national perinatal health indicators in Europe Open
Context: International comparisons of the health of mothers and babies provide essential benchmarks for guiding health practice and policy, but statistics are not routinely compiled in a comparable way. These data are especially critical d…
View article: Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events
Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events Open
This work was supported by CIBER (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea-NextGenerationEU; by the Spanish AIDS Research Network (RIS) RD16/0025/0001 project as part of the Plan Naciona…
Open data to support European pandemic preparedness. Open
BY-COVID learnings and policy recommendations after 18 months of cross-disciplinary collaboration As seen during the COVID-19 pandemic, and other infectious disease outbreaks, researchers, health care professionals and "citizens (in terms …
Open data to support European pandemic preparedness. Open
BY-COVID learnings and policy recommendations after 18 months of cross-disciplinary collaboration As seen during the COVID-19 pandemic, and other infectious disease outbreaks, researchers, health care professionals and "citizens (in terms …