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View article: Global & Community Health: What Did the COVID-19 Pandemic Teach Us About Neurologic Surveillance Approaches, and How Should We Be Better Prepared?
Global & Community Health: What Did the COVID-19 Pandemic Teach Us About Neurologic Surveillance Approaches, and How Should We Be Better Prepared? Open
It is well recognized that many pandemic viruses are associated with neurologic complications, most recently with COVID-19. After the outbreak of the COVID-19 pandemic, neurologic surveillance platforms were implemented to characterize the…
View article: Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease
Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease Open
Importance Adaptive deep brain stimulation (aDBS) automatically adjusts stimulation amplitude in response to changes in relevant neural activity in people with Parkinson disease (PD). Whether long-term at-home aDBS is safe and delivers eff…
View article: Editor’s Pick: Precision Medicine in Neurology: Advancing Care for Female Patients
Editor’s Pick: Precision Medicine in Neurology: Advancing Care for Female Patients Open
Growing evidence suggests that biological sex influences disease risk, clinical presentation, treatment response, and prognosis across neurological conditions. Despite this increasing awareness of important sex differences, neurological re…
View article: Neuropsychiatric fluctuations in Parkinson's disease: A French multicenter study of the NFS psychometric properties
Neuropsychiatric fluctuations in Parkinson's disease: A French multicenter study of the NFS psychometric properties Open
This study confirms that the NFS is a reliable tool to evaluate NpsyF in PD patients in an acute setting.
View article: Deep Brain Stimulation for <scp> <i>VPS16</i> </scp> ‐Related Dystonia: A Multicenter Study
Deep Brain Stimulation for <span> <i>VPS16</i> </span> ‐Related Dystonia: A Multicenter Study Open
Objective The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16 ‐related dystonia. Methods This observational study collected preoperative and postoperative demographic,…
View article: Twenty-five-year experience with apomorphine pump in Parkinson's disease: A real-life long-term retrospective tolerance study
Twenty-five-year experience with apomorphine pump in Parkinson's disease: A real-life long-term retrospective tolerance study Open
Background Continuous subcutaneous apomorphine infusion (CSAI) is a standard of care treatment in advanced Parkinson's disease (PD) to treat motor fluctuations. However, literature about its long-term data is scarce. Objective The aim of t…
View article: Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID‐19 task force of the European Academy of Neurology
Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID‐19 task force of the European Academy of Neurology Open
Background Neuropathological and clinical studies suggest that infection with SARS-CoV-2 may increase the long-term risk of neurodegeneration. Methods We provide a narrative overview of pathological and clinical observations justifying the…
View article: Chronic adaptive versus conventional deep brain stimulation in Parkinson’s disease: a blinded randomized pilot trial
Chronic adaptive versus conventional deep brain stimulation in Parkinson’s disease: a blinded randomized pilot trial Open
Background Adaptive deep brain stimulation (aDBS) is becoming a feasible therapeutic option in patients who are candidates for DBS, and implantable devices are now commercially available. We present the results of a blinded, randomized, cr…
View article: A roadmap toward promoting and improving brain health in Europe and closing the awareness and funding gap
A roadmap toward promoting and improving brain health in Europe and closing the awareness and funding gap Open
Background and Purpose The global burden of neurological diseases exceeds 43.1%, imposing a significant burden on patients, caregivers and society. This paper presents a roadmap to reduce this burden and improve brain health (BH) in Europe…
View article: How well is the female population represented in clinical trials with infusion therapies for Parkinson's disease? A systematic review and metanalysis
How well is the female population represented in clinical trials with infusion therapies for Parkinson's disease? A systematic review and metanalysis Open
Background Parkinson's disease (PD) is a neurodegenerative disorder affecting both sexes, but differences exist between male and female in clinical manifestations, functional impact of symptoms and hormonal influences. Therefore, represent…
View article: Bilateral Lesions in Parkinson's Disease: Gaps and Controversies
Bilateral Lesions in Parkinson's Disease: Gaps and Controversies Open
Bilateral lesions of the basal ganglia using termocoagulation or radiation for improving tremor, bradykinesia, and rigidity in people with Parkinson's disease (PD) have been performed starting several decades ago, especially when levodopa …
View article: Pediatric-onset <i>PRKN</i> disease: New insights into an understudied population
Pediatric-onset <i>PRKN</i> disease: New insights into an understudied population Open
Background In pediatric age, the PRKN mutation is reported as one of the most common genetic causes of Parkinson's disease. However, detailed clinical data on PRKN patients with pediatric onset are scarce. Objective To describe clinical ch…
View article: Deep brain stimulation for severe dystonia associated with Wilson disease: A prospective multicenter meta‐analysis of an N‐of‐1 trial
Deep brain stimulation for severe dystonia associated with Wilson disease: A prospective multicenter meta‐analysis of an N‐of‐1 trial Open
Background and purpose Disabling dystonia despite optimal medical treatment is common in Wilson disease (WD). No controlled study has evaluated the effect of deep brain stimulation (DBS) on dystonia related to WD. This study was undertaken…
View article: Brain health and national neurological societies: Results of the European Academy of Neurology survey on brain health awareness and areas of implementation for European countries
Brain health and national neurological societies: Results of the European Academy of Neurology survey on brain health awareness and areas of implementation for European countries Open
Background and purpose The European Academy of Neurology (EAN) has adhered to the global plan for reducing the burden of neurological disorders and promoting brain health launched by the World Health Organisation (WHO), the WHO Intersector…
View article: Visual dysfunction of superior colliculus and lateral geniculate nucleus in idiopathic blepharospasm
Visual dysfunction of superior colliculus and lateral geniculate nucleus in idiopathic blepharospasm Open
Our findings support the concept of SC and LGN dysfunction in idiopathic BP. Brain fMRI, targeting these sub-cortical visual structures, could play a future important role both as a biomarker and in our understanding of the pathophysiology…
View article: Autonomic nervous system education in Europe: <scp>EAN</scp>/<scp>EFAS</scp>/<scp>INUS</scp> survey on curricula and skills in autonomic medicine of European neurology residents and consultants
Autonomic nervous system education in Europe: <span>EAN</span>/<span>EFAS</span>/<span>INUS</span> survey on curricula and skills in autonomic medicine of European neurology residents and consultants Open
Background and purpose Centers for training in autonomic nervous system (ANS) disorders are not widely available and the recent coronavirus 2019 pandemic temporarily reduced training opportunities in autonomic medicine across European coun…
View article: Dystonic Tremor as Main Clinical Manifestation of SCA21
Dystonic Tremor as Main Clinical Manifestation of SCA21 Open
Background Spinocerebellar ataxia type 21 (SCA21) is a rare inherited neurological disorder characterized by motor, cognitive, and behavioral disturbances, caused by autosomal dominant TMEM240 variants. Objectives To identify the genetic c…
View article: Physical therapy in patients with Parkinson’s disease treated with Deep Brain Stimulation: a Delphi panel study
Physical therapy in patients with Parkinson’s disease treated with Deep Brain Stimulation: a Delphi panel study Open
Although deep brain stimulation of the subthalamic nucleus (STN-DBS) induces motor benefits in people with Parkinson’s disease (PwPD), the size and duration of the effects of STN-DBS on motor axial (e.g., postural instability, trunk postur…
View article: European Academy of Neurology: First 10 years
European Academy of Neurology: First 10 years Open
The European Academy of Neurology (EAN) was founded in May 2014 as the scientific society of all neurologists and all national neurological societies in Europe. The creation of EAN was based on the conscious decision of two predecessor soc…
View article: Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial
Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial Open
Adaptive deep brain stimulation (aDBS) is an emerging advancement in DBS technology; however, local field potential (LFP) signal rate detection sufficient for aDBS algorithms and the methods to set-up aDBS have yet to be defined. Here we s…