Wernér E.G. Müller
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View article: Inorganic polyphosphate, a paradigm changer in 3D printing of <i>β</i>-tricalcium phosphate based materials for bone tissue surgery
Inorganic polyphosphate, a paradigm changer in 3D printing of <i>β</i>-tricalcium phosphate based materials for bone tissue surgery Open
β -Tricalcium phosphate ( β -TCP) is widely used as a material for bone implants due to its excellent biocompatibility, biodegradability, and osteoconductivity, as well as its osteoinductive properties. Here, we demonstrate that the regene…
View article: Exploring selective solidarity with refugees in Germany: the role of political orientation and national glorification / <i>Exploración de la solidaridad selectiva con los refugiados en Alemania: el papel de la orientación política y la glorificación nacional</i>
Exploring selective solidarity with refugees in Germany: the role of political orientation and national glorification / <i>Exploración de la solidaridad selectiva con los refugiados en Alemania: el papel de la orientación política y la glorificación nacional</i> Open
Studies and public opinion polls in Germany reveal double standards in the acceptance of Ukrainian versus Black/Arab and Muslim refugees. In three studies ( N = 2,839) conducted in Germany, we confirm a selective solidarity effect: Germans…
View article: “Only the Blue‐Eyed Ones”: How Refugees' Origin and Gender Affect Selective Solidarity Through Perceived Similarity and Threat
“Only the Blue‐Eyed Ones”: How Refugees' Origin and Gender Affect Selective Solidarity Through Perceived Similarity and Threat Open
This paper investigates social psychological mechanisms underlying selective solidarity with refugees in two experimental studies conducted in Germany. We hypothesized, in line with the geopolitics of racialization and masculinization of r…
View article: Proximity Extension Assay identifies new targets of grey matter pathology in multiple sclerosis
Proximity Extension Assay identifies new targets of grey matter pathology in multiple sclerosis Open
Grey matter (GM) lesions and atrophy in multiple sclerosis (MS) are strongly correlated to disease progression and cognitive decline, but molecular mechanisms underlying GM lesion formation remain unclear. Various studies have used a prote…
View article: “Only the blue-eyed ones”: how refugees' origin and gender affect selective allyship through perceived similarity and threat
“Only the blue-eyed ones”: how refugees' origin and gender affect selective allyship through perceived similarity and threat Open
This paper investigates social psychological mechanisms underlying selective solidarity with refugees in two experimental studies conducted in Germany. We hypothesized, in line with the geopolitics of racialisation and masculinisation of r…
View article: Exploring Selective Solidarity with Refugees in Germany: The Role of Political Orientation and National Glorification
Exploring Selective Solidarity with Refugees in Germany: The Role of Political Orientation and National Glorification Open
Studies and public opinion polls in Germany reveal double standards in the acceptance of Ukrainian versus Black/Arab and Muslim refugees. In three studies (N = 2839) conducted in Germany, we confirm a selective solidarity effect: Germans e…
View article: Decoupling inert and reactive gas supply to optimize ion beam sputter deposition apparatus for a more efficient material deposition
Decoupling inert and reactive gas supply to optimize ion beam sputter deposition apparatus for a more efficient material deposition Open
For all technologies, the energy-payback time (EPBT) serves as a critical metric. As an example, we study ion beam sputter deposition (IBSD), a sputter deposition approach where plasma, target, and substrate are decoupled. We compare three…
View article: Polyphosphate Nanoparticles: Balancing Energy Requirements in Tissue Regeneration Processes
Polyphosphate Nanoparticles: Balancing Energy Requirements in Tissue Regeneration Processes Open
Nanoparticles of a particular, evolutionarily old inorganic polymer found across the biological kingdoms have attracted increasing interest in recent years not only because of their crucial role in metabolism but also their potential medic…
View article: Evaluation of a novel triplex immunochromatographic test for rapid simultaneous detection of norovirus, rotavirus, and adenovirus on a single strip test
Evaluation of a novel triplex immunochromatographic test for rapid simultaneous detection of norovirus, rotavirus, and adenovirus on a single strip test Open
The triplex immunochromatographic test kit (IC-A) designed for simultaneous detection of norovirus, rotavirus, and adenovirus has been proved to be more practical and convenient than the use of single or dual detection kits with more or le…
View article: The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine
The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine Open
There is a need for novel nanomaterials with properties not yet exploited in regenerative nanomedicine. Based on lessons learned from the oldest metazoan phylum, sponges, it has been recognized that two previously ignored or insufficiently…
View article: Microfragmented Fat and Biphasic Calcium Phosphates for Alveolar Cleft Repair: Protocol for a Prospective, Nonblinded, First-in-Human Clinical Study
Microfragmented Fat and Biphasic Calcium Phosphates for Alveolar Cleft Repair: Protocol for a Prospective, Nonblinded, First-in-Human Clinical Study Open
Background Biphasic calcium phosphates (BCP) may serve as off-the-shelf alternatives for iliac crest-derived autologous bone in alveolar cleft reconstructions. To add osteoinductivity to the osteoconductive BCPs to achieve similar regenera…
View article: Caryophyllene-type sesquiterpenes from the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach
Caryophyllene-type sesquiterpenes from the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach Open
Two new caryophyllene-type sesquiterpenes pestalotiopsins U and V ( 1 and 2 ) and three known compounds pestalotiopsin B ( 7 ), pestaloporinate B ( 8 ), and pestalotiopsin C ( 9 ) were isolated by the cultivation of the endophytic fungus P…
View article: Cell migration, DNA fragmentation and antibacterial properties of novel silver doped calcium polyphosphate nanoparticles
Cell migration, DNA fragmentation and antibacterial properties of novel silver doped calcium polyphosphate nanoparticles Open
View article: Energy level as a theranostic factor for successful therapy of tissue injuries with polyphosphate: the triad metabolic energy - mechanical energy - heat
Energy level as a theranostic factor for successful therapy of tissue injuries with polyphosphate: the triad metabolic energy - mechanical energy - heat Open
Rationale: Tissue regeneration of skin and bone is an energy-intensive, ATP-consuming process that, if impaired, can lead to the development of chronic clinical pictures. ATP levels in the extracellular space including the exudate o…
View article: Liquid–liquid phase transition as a basis for novel materials for skin repair and regeneration
Liquid–liquid phase transition as a basis for novel materials for skin repair and regeneration Open
Polyphosphate (polyP) is a physiologically significant polymer with regenerative properties, crucial for supplying the metabolic fuel (ATP) essential for various regeneration processes in humans, including wound healing.
View article: Editorial: Ecological distribution, functional diversity, and the biogeochemical cycle of microorganisms in karst
Editorial: Ecological distribution, functional diversity, and the biogeochemical cycle of microorganisms in karst Open
EDITORIAL article Front. Microbiol., 11 August 2023Sec. Terrestrial Microbiology Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1265640
View article: Ascorbyl palmitate–PCL fiber mats loaded with strontium polyphosphate nanoparticles for guided bone regeneration
Ascorbyl palmitate–PCL fiber mats loaded with strontium polyphosphate nanoparticles for guided bone regeneration Open
Multifunctional fiber mats are explored as potential bioactive matrices for the development of the next generation of guided bone regeneration membranes with tunable microstructure, strength and therapeutic activity. In the present study, …
View article: Supplementary Figures 1 - 4 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary Figures 1 - 4 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
PDF file - 149K, Suppl. Figure 1. The induction of colitis-associated colon cancer alters the expression of GARP, CD103 and CTLA-4 on T cells and regulatory T cells. Suppl. Figure 2. Increased percentages of regulatory T cells in the perip…
View article: Data from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Data from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
Regulatory T cells (Treg) are supportive to cancer development in most tissues, but their role in colitis-associated colon cancer (CAC) remains unclear. In this study, we investigated the role of CD4+Foxp3+ Treg in a …
View article: Supplementary Figure Legends from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary Figure Legends from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
PDF file - 204K
View article: Supplementary Figure Legends from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary Figure Legends from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
PDF file - 204K
View article: Data from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Data from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
Regulatory T cells (Treg) are supportive to cancer development in most tissues, but their role in colitis-associated colon cancer (CAC) remains unclear. In this study, we investigated the role of CD4+Foxp3+ Treg in a …
View article: Supplementary Figures 1 - 4 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary Figures 1 - 4 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
PDF file - 149K, Suppl. Figure 1. The induction of colitis-associated colon cancer alters the expression of GARP, CD103 and CTLA-4 on T cells and regulatory T cells. Suppl. Figure 2. Increased percentages of regulatory T cells in the perip…
View article: Supplementary Tables 1 - 2 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary Tables 1 - 2 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
PDF file - 43K, Supplemental Table 1. Characteristics of colon cancer patients included in the study. Supplemental Table 2. Primers.
View article: Supplementary Tables 1 - 2 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary Tables 1 - 2 from Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer Open
PDF file - 43K, Supplemental Table 1. Characteristics of colon cancer patients included in the study. Supplemental Table 2. Primers.
View article: Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate
Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate Open
Amorphous calcium carbonate (ACC), precipitated in the presence of inorganic polyphosphate (polyP), has shown promise as a material for bone regeneration due to its morphogenetic and metabolic energy (ATP)-delivering properties. The latter…
View article: Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study
Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study Open
Manzamines are chemically related compounds extracted from the methanolic extract of Acanthostrongylophora ingens species. Seven compounds were identified by our research group and are being characterized. As their biological target is unk…
View article: Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications
Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications Open
Inorganic polyphosphates (polyP) are long-chain polymers of orthophosphate residues, which, depending on the external conditions, can be present both physiologically and synthetically in either soluble, nanoparticulate or coacervate form. …
View article: Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update
Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update Open
Our respiratory system is exposed to toxicants and pathogens from both sides: the airways and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural barrier in the airways, endothelial cells protect the lun…