Nuzhat Ahmed
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View article: Oligodendrocyte progenitor cell responses to inflammatory demyelination with aging
Oligodendrocyte progenitor cell responses to inflammatory demyelination with aging Open
Oligodendrocyte progenitor cells (OPCs) have the capacity to self-renew, differentiate into mature myelinating cells, and remyelinate the central nervous system in response to demyelination. Normal aging is associated with a reduction in t…
View article: Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial–Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets
Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial–Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets Open
Epithelial ovarian cancer is aggressive and causes high mortality among women worldwide. Members of the plakin family are essential to maintain cytoskeletal integrity and key cellular processes. In this study we characterised the expressio…
View article: A Retrospective Analysis of Epidemiology and Clinical Outcomes of Patients with Epithelial Ovarian Tumors Treated in Ain Shams Clinical Oncology Department in the Period from 2017 Till 2020. Ain Shams Clinical Oncology Registry (ASCOR)
A Retrospective Analysis of Epidemiology and Clinical Outcomes of Patients with Epithelial Ovarian Tumors Treated in Ain Shams Clinical Oncology Department in the Period from 2017 Till 2020. Ain Shams Clinical Oncology Registry (ASCOR) Open
Background OC is the 3rd most commonly diagnosed gynecological malignancy and ranked 2nd most common cause of gynecological malignancies deaths. In our study we reviewed medical records of 97 patients including demographic data and clinico…
View article: In Vitro and In Silico Analysis of Epithelial-Mesenchymal Transition and Cancer Stemness as Prognostic Markers of Clear Cell Renal Cell Carcinoma
In Vitro and In Silico Analysis of Epithelial-Mesenchymal Transition and Cancer Stemness as Prognostic Markers of Clear Cell Renal Cell Carcinoma Open
The process of epithelial-mesenchymal transition (EMT) involves the phenotypic transformation of cells from epithelial to mesenchymal status. The cells exhibiting EMT contain features of cancer stem cells (CSC), and the dual processes are …
View article: Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer
Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer Open
Background The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer progression. This s…
View article: Precision Medicine: An Optimal Approach to Patient Care in Renal Cell Carcinoma
Precision Medicine: An Optimal Approach to Patient Care in Renal Cell Carcinoma Open
Renal cell cancer (RCC) is a heterogeneous tumor that shows both intra- and inter-heterogeneity. Heterogeneity is displayed not only in different patients but also among RCC cells in the same tumor, which makes treatment difficult because …
View article: Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment
Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment Open
Background The tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP…
View article: Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma
Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma Open
Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its early promising results in decreasing or delaying the progress…
View article: The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence
The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence Open
The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the maintenance of cytoskeletal int…
View article: Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods
Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods Open
Epithelial ovarian cancer (EOC) constitutes 90% of ovarian cancers (OC) and is the eighth most common cause of cancer-related death in women. The cancer histologically and genetically is very complex having a high degree of tumour heteroge…
View article: Early Detection of Atrial Fibrillation Based on ECG Signals
Early Detection of Atrial Fibrillation Based on ECG Signals Open
Atrial fibrillation, often called AF is considered to be the most common type of cardiac arrhythmia, which is a major healthcare challenge. Early detection of AF and the appropriate treatment is crucial if the symptoms seem to be consisten…
View article: Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer
Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer Open
Approximately seventy percent of ovarian cancer patients succumb to the disease within the first 5 years of diagnosis, even after successful surgery and effective chemotherapy treatment. A small subset of chemotherapy resistant cancer stem…
View article: The Potential Role of Interleukin-11 in Epithelial Ovarian Cancer
The Potential Role of Interleukin-11 in Epithelial Ovarian Cancer Open
Interleukin-11 (IL-11) has recently gained attention in cancer biology, and there is now an upsurge in IL-11 research with studies implicating a role of IL-11 in several human cancers of epithelial and hematopoietic origins. The identifica…
View article: Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells
Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells Open
Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cel…
View article: Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer
Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer Open
Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phases of recurrences; and nearly 60% die within 5 years due to the development of a chemoresistant disease. This …
View article: The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression
The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression Open
Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in …
View article: Indigenous Oil Degrading Bacteria: Isolation, Screening and Characterization
Indigenous Oil Degrading Bacteria: Isolation, Screening and Characterization Open
Background: Oil contamination is increasing at an alarming rate and to overcome to this problem the most efficient method used is biodegradation. Biodegradation is a natural mechanism that can be used effectively for degradation of recalci…
View article: Outcome of Inversion 16 in TKD Positive and Negative Acute Myeloid Leukemia Patients
Outcome of Inversion 16 in TKD Positive and Negative Acute Myeloid Leukemia Patients Open
View article: Coexisting JAK2V617F and CALR Exon 9 Mutations in Myeloproliferative Neoplasms - Do They Designate a New Subtype?
Coexisting JAK2V617F and CALR Exon 9 Mutations in Myeloproliferative Neoplasms - Do They Designate a New Subtype? Open
The classic BCR-ABL1-negative myeloproliferative neoplasm is an operational sub-category of MPNs that includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The JAK2V617F mutation is found in ~ 95…
View article: Chronic Myeloid Leukemia - Prognostic Value of Mutations
Chronic Myeloid Leukemia - Prognostic Value of Mutations Open
Chronic myeloid leukemia (CML) is a stem cell disorder characterized by unrestricted proliferation of the myeloid series that occurs due to the BCR-ABL fusion oncogene as a result of reciprocal translocation t(9;22) (q34;q11). This discove…
View article: Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment: Replicative immortality
Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment: Replicative immortality Open
A correction has been published: Carcinogenesis, Volume 37, Issue 3, March 2016, Page 344, https://doi.org/10.1093/carcin/bgv155.