Paul Emery
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View article: Living with palindromic rheumatism: a qualitative interview study
Living with palindromic rheumatism: a qualitative interview study Open
Objectives Palindromic rheumatism (PR) is an unpredictable and under-researched inflammatory condition, and patients with PR are at risk of developing inflammatory arthritis (IA). This study aimed to explore patients’ perceptions and exper…
View article: Ultrasound-detected inflammation and structural changes in the joints, tendons and entheses of patients with cancer who developed arthritis or arthralgia after exposure to immune checkpoint inhibitors
Ultrasound-detected inflammation and structural changes in the joints, tendons and entheses of patients with cancer who developed arthritis or arthralgia after exposure to immune checkpoint inhibitors Open
Objectives To explore the prevalence and distribution of ultrasound-detected inflammation and structural damage in the joints, tendons and entheses of patients who developed new-onset arthritis or arthralgia following exposure to immune ch…
View article: Predicting rapid radiographic progression in difficult-to-treat rheumatoid arthritis: insights from long-term follow-up
Predicting rapid radiographic progression in difficult-to-treat rheumatoid arthritis: insights from long-term follow-up Open
Objectives To investigate the long-term trajectory of radiographic progression in difficult-to-treat rheumatoid arthritis (D2T RA) and poly-refractory RA (pr-RA) patients and to evaluate the impact of ultrasound-based persistent inflammato…
View article: Augmentation of immunothrombosis as a key mechanism underlying JAK inhibition associated hypercoagulability in rheumatoid arthritis
Augmentation of immunothrombosis as a key mechanism underlying JAK inhibition associated hypercoagulability in rheumatoid arthritis Open
Immunothrombosis offers a novel explanation for JAKi-associated VTE in RA.
View article: Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study
Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study Open
This study reveals a high prevalence of ultrasound-detected structural damage at the enthesis and identifies distinct SpA phenotypes based on these findings.
View article: Whole-body MRI in patients with arthralgia or inflammatory arthritis after exposure to immune checkpoint inhibitors: a single-centre prospective imaging study
Whole-body MRI in patients with arthralgia or inflammatory arthritis after exposure to immune checkpoint inhibitors: a single-centre prospective imaging study Open
The National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre.
View article: RITUXIMAB SUPER-RESPONDERS: CHARACTERISTICS OF PATIENTS WITH MORE THAN 3 YEARS RESPONSE TO A SINGLE CYCLE OF TREATMENT
RITUXIMAB SUPER-RESPONDERS: CHARACTERISTICS OF PATIENTS WITH MORE THAN 3 YEARS RESPONSE TO A SINGLE CYCLE OF TREATMENT Open
PV266 / #632 Poster Topic: AS24 - SLE-Treatment Background/Purpose Rituximab has been used to treat SLE for 20 years but efficacy is limited by inadequate B cell depletion. Emerging therapies such as CD19 CAR-T-cells have been reported to …
View article: OA09 Progression of foot involvement in individuals at risk of rheumatoid arthritis: findings from a UK cohort study
OA09 Progression of foot involvement in individuals at risk of rheumatoid arthritis: findings from a UK cohort study Open
Background/Aims Foot involvement is prevalent and disabling in rheumatoid arthritis (RA); foot symptoms persist even when clinical remission is achieved. Targeted therapies for local inflammation and mechanically-based impairments (foot or…
View article: Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study
Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study Open
Introduction The phase III SELECT-MONOTHERAPY trial ( NCT02706951 ) demonstrated the safety and efficacy of upadacitinib (UPA) monotherapy through 84 weeks in patients with rheumatoid arthritis who responded inadequately to methotrexate. H…
View article: P158 Effectiveness and safety of rituximab and cyclophosphamide for the treatment of Sjögren’s disease-related peripheral neuropathy: a retrospective cohort study
P158 Effectiveness and safety of rituximab and cyclophosphamide for the treatment of Sjögren’s disease-related peripheral neuropathy: a retrospective cohort study Open
Background/Aims Up to 15% of patients with Sjögren’s disease (SjD) may develop peripheral neuropathy (PN). Although uncommon, this feature leads to severe disability and high symptom burden. There are limited data on the effectiveness of i…
View article: Baseline synovitis–tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state
Baseline synovitis–tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state Open
Objectives The objectives of this study were to investigate the association between baseline joint-complex inflammation [power Doppler–detected joint synovitis (PDUS) and/or tenosynovitis (PDTS)] and remission in treatment-naïve, new-onset…
View article: Association Between Abatacept Exposure Levels and Infection Occurrence in Patients With Rheumatoid Arthritis: Post Hoc Analysis of the AVERT-2 Study
Association Between Abatacept Exposure Levels and Infection Occurrence in Patients With Rheumatoid Arthritis: Post Hoc Analysis of the AVERT-2 Study Open
Objective To determine whether higher serum exposure during subcutaneous (SC) abatacept (ABA) treatment was associated with an increased infection risk in adult patients with early rheumatoid arthritis (RA). Methods Data from Assessing Ver…
View article: Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study
Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study Open
Objectives DARWIN 3 (ClinicalTrials.gov: NCT02065700 ) assessed the safety and efficacy of filgotinib in a long-term extension (LTE) of two phase II randomised controlled rheumatoid arthritis (RA) trials. Methods Eligible patients completi…
View article: Improving the arthritis component of the SLEDAI-2K
Improving the arthritis component of the SLEDAI-2K Open
Objective To propose a new definition for SLEDAI arthritis informed by imaging. Methods We performed a planned secondary analysis of observational data from a multicentre study evaluating SLE patients with inflammatory joint pain (swelling…
View article: A multivariable prediction model to identify anti-CCP positive people in those with non-specific musculoskeletal symptoms in primary care
A multivariable prediction model to identify anti-CCP positive people in those with non-specific musculoskeletal symptoms in primary care Open
Objectives We aimed to develop a prediction model identifying people presenting to primary care with musculoskeletal symptoms likely to be anti-CCP positive and therefore at risk of developing RA. Methods Participants aged ≥16 years, with …
View article: Dynamics of the gut microbiome in individuals at risk of rheumatoid arthritis: a cross-sectional and longitudinal observational study
Dynamics of the gut microbiome in individuals at risk of rheumatoid arthritis: a cross-sectional and longitudinal observational study Open
These data suggest conflicting reports on Prevotellaceae overabundance are likely due to sampling within a heterogeneous population along a dynamic disease spectrum, with certain Prevotellaceae strains/clades possibly contributing to the e…
View article: Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study
Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study Open
Background Janus kinase inhibitors are an effective option for achieving sustained remission or low disease activity in patients with rheumatoid arthritis (RA) following inadequate response to conventional synthetic disease-modifying anti-…
View article: Biomarkers in the diagnosis, prognosis and management of rheumatoid arthritis: A comprehensive review
Biomarkers in the diagnosis, prognosis and management of rheumatoid arthritis: A comprehensive review Open
Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune condition that primarily affects the joints and periarticular soft tissues. In the past two decades, the discovery of new biomarkers has contributed to advances in the understand…