Annette Peters
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View article: Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes Open
Background Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-charact…
View article: Theobromine is associated with slower epigenetic ageing
Theobromine is associated with slower epigenetic ageing Open
Theobromine, a commonly consumed dietary alkaloid derived from cocoa, has been linked to extended lifespan in model organisms and to health benefits in humans. We examined associations between circulating levels of theobromine intake, meas…
View article: Improvements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change
Improvements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change Open
Previous attribution studies of heat-related excess mortality have given limited attention to temporal trends in vulnerability and their non-climatic drivers. Here, we address this gap by combining counterfactual temperature data derived f…
View article: Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis
Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis Open
Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. Methods We investigated associations …
View article: Long-term exposure to traffic-related air pollution is associated with epigenetic age acceleration
Long-term exposure to traffic-related air pollution is associated with epigenetic age acceleration Open
Epigenetic aging biomarkers, predicted by selected Cytosine-phosphate-Guanine (CpG) sites, might be influenced by air pollution exposure. However, evidence from longitudinal studies is still limited. This study aims to determine the associ…
View article: Multiple polygenic score approach in colorectal cancer risk prediction
Multiple polygenic score approach in colorectal cancer risk prediction Open
Recent studies have demonstrated that for various diseases, incorporating polygenic risk scores (PRSs) for other traits and diseases into the PRS-based risk prediction model may improve predictive performance – known as Multiple Polygenic …
View article: DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease
DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease Open
Aims/hypothesis Despite playing critical roles in the pathophysiology of type 2 diabetes and other metabolic disorders, the molecular mechanisms underlying circulating adipokine levels remain poorly understood. By identifying genomic regio…
View article: Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease Open
Background Obesity is thought to increase cardiovascular disease (CVD) risk partly through dyslipidemia. Yet, obesity’s effects on dyslipidemia are not uniform. Understanding the shared genetic basis between obesity and lipid traits can pr…
View article: Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence
Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence Open
Background MicroRNAs (miRNAs) are short, single-stranded RNAs that function as post-transcriptional regulators of gene expression. Although circulating miRNAs have been linked to carcinogenesis, they have not yet been systematically invest…
View article: Intersectional inequalities in health in Germany: The effects of sex, education, and migration
Intersectional inequalities in health in Germany: The effects of sex, education, and migration Open
Background Persisting health inequalities for females, those with less education, and those with migration background have been documented in Germany and Europe, but few studies have used intersectional methods to assess the combined effec…
View article: Predictive prioritization of enhancers associated with pancreatic disease risk
Predictive prioritization of enhancers associated with pancreatic disease risk Open
Genetic and epigenetic variation in enhancers is associated with disease susceptibility; however, linking enhancers to target genes and predicting enhancer dysfunction remain challenging. We mapped enhancer-promoter interactions in human p…
View article: Self-rated health and mental health before and during the early phase of the COVID-19 pandemic in Germany: the population-based German National Cohort (NAKO) study (Preprint)
Self-rated health and mental health before and during the early phase of the COVID-19 pandemic in Germany: the population-based German National Cohort (NAKO) study (Preprint) Open
BACKGROUND The COVID-19 pandemic and accompanying social distancing measures might have caused adverse health consequences. OBJECTIVE To describe changes in participants’ self-rated health and mental health (depression, anxiety, and str…
View article: Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety
Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety Open
We applied deep normative modeling to structural MRI data from two large cohorts (German National Cohort, N ≈ 29,000 and UK Biobank, N ≈ 25,000) to characterize individual-level brain deviations along symptom dimensions of depression, anxi…
View article: Long-term exposure to ultrafine particles and its association with cardiometabolic diseases, chronic obstructive pulmonary disease, and cardiometabolic biomarkers: A cross-sectional analysis of the German National cohort (NAKO)
Long-term exposure to ultrafine particles and its association with cardiometabolic diseases, chronic obstructive pulmonary disease, and cardiometabolic biomarkers: A cross-sectional analysis of the German National cohort (NAKO) Open
There is limited epidemiological evidence regarding the health effects of ultrafine particles (UFP; particles with an aerodynamic diameter of 10-100 nm). This study investigated whether long-term exposure to total particle number concentra…
View article: Development of a quantitative job exposure matrix for standing, walking, and forward bending among pregnant workers – The PRECISE JEM
Development of a quantitative job exposure matrix for standing, walking, and forward bending among pregnant workers – The PRECISE JEM Open
OBJECTIVES: Occupational physical activity (OPA) during pregnancy has been linked to adverse pregnancy outcomes, but crude exposure assessment remains an issue in causal inference. We aimed to develop a quantitative trimester-specific job …
View article: Migration and cardiovascular disease: A comparative study of prevalence and risk factor profiles in resettlers from the German National Cohort (NAKO)
Migration and cardiovascular disease: A comparative study of prevalence and risk factor profiles in resettlers from the German National Cohort (NAKO) Open
We compared the prevalence of cardiovascular diseases (CVD) in a special group of migrants (resettlers from the former Soviet Union; German: (Spät-)Aussiedler) and autochthonous Germans, using data from the German National Cohort (NAKO) an…
View article: Pleiotropic effects between statin intake and inflammation parameters in two distinct population-based studies
Pleiotropic effects between statin intake and inflammation parameters in two distinct population-based studies Open
Background: Besides their lipid lowering effects, statins exhibit numerous beneficial and adverse effects (so called pleiotropic effects). A major pleiotropic effect of statins is their anti-inflammatory properties, but the impact on a wid…
View article: Association of Inflammatory and Cardiovascular Proteomics Biomarkers With Indices of Heart Rate Variability in the General Population: KORA S4/FF4 Study
Association of Inflammatory and Cardiovascular Proteomics Biomarkers With Indices of Heart Rate Variability in the General Population: KORA S4/FF4 Study Open
Background We sought to investigate the association between circulating inflammatory and cardiovascular proteomics biomarkers and cardiac autonomic nervous dysfunction–sensitive heart rate variability indices. Methods Using the population‐…
View article: Urban pollution impact assessment in six Lithuanian cities with a focus on road traffic emissions - integrated framework for environmental health studies
Urban pollution impact assessment in six Lithuanian cities with a focus on road traffic emissions - integrated framework for environmental health studies Open
An integrated framework is introduced and applied to assess the health impact of airborne pollution with greater physiological relevance, moving beyond conventional exposure metrics. Measured particle number size distribution data was inte…
View article: Genetic risk factors modulate the association between physical activity and colorectal cancer
Genetic risk factors modulate the association between physical activity and colorectal cancer Open
Background Physical activity (PA) is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene–PA interaction an…
View article: Longitudinal study reveals plasma glycans associations with prediabetes/type 2 diabetes in KORA study
Longitudinal study reveals plasma glycans associations with prediabetes/type 2 diabetes in KORA study Open
Background Altered plasma N-glycosylation is increasingly recognized as a contributor to metabolic dysregulation. This study aimed to investigate the role of plasma N-glycans in glucose metabolism and the progression from normoglycemia to …