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View article: Intranasal Esketamine Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder with Comorbid Major Depressive Disorder: A Case Series of Eight Patients
Intranasal Esketamine Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder with Comorbid Major Depressive Disorder: A Case Series of Eight Patients Open
Background: Intranasal esketamine has gained attention as a rapidly acting intervention for treatment-resistant depression, and there is growing interest in its potential anti-obsessional effects. To our knowledge, no published case series…
View article: Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder Open
Studies of brain morphology in mental illness often incompletely characterize structural variation, focusing on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder …
View article: Development and validation of a machine learning model to predict cognitive behavioral therapy outcome in obsessive-compulsive disorder using clinical and neuroimaging data
Development and validation of a machine learning model to predict cognitive behavioral therapy outcome in obsessive-compulsive disorder using clinical and neuroimaging data Open
Machine learning models based on clinical data may thus hold promise in predicting remission after CBT for OCD, but the predictive power of multicenter rs-fMRI data is limited.
View article: Development and validation of a machine learning model to predict cognitive behavioral therapy outcome in obsessive-compulsive disorder using clinical and neuroimaging data
Development and validation of a machine learning model to predict cognitive behavioral therapy outcome in obsessive-compulsive disorder using clinical and neuroimaging data Open
Cognitive behavioral therapy (CBT) is a first-line treatment for obsessive-compulsive disorder (OCD), but clinical response is difficult to predict. In this study, we aimed to develop predictive models using clinical and neuroimaging data …
View article: Neuropsychological functions as endophenotype markers in ocd: a long term follow-up
Neuropsychological functions as endophenotype markers in ocd: a long term follow-up Open
Introduction Obssesive Compulsive Disorder (OCD) is characterized by impaired neuropsychological functions that are also influenced by clinical variables and aging. According to the literature, several of these neuropsychological deficits …
View article: Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group Open
View article: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group Open
View article: Sex differences in clinical response to deep brain stimulation in resistant obsessive-compulsive disorder
Sex differences in clinical response to deep brain stimulation in resistant obsessive-compulsive disorder Open
Our results suggest that gender could influence the long-term response to DBS in OCD, a finding that needs to be confirmed in new studies given the paucity of results on predictors of response to DBS.
View article: Pattern of neuropsychological performance and dysfunctional beliefs in a high-risk population for Obsessive-compulsive disorder and their affected parents
Pattern of neuropsychological performance and dysfunctional beliefs in a high-risk population for Obsessive-compulsive disorder and their affected parents Open
View article: Clinical characteristics of children of adult parents affected by Obsessive-compulsive disorder. dysfunctional beliefs and pattern of neuropsychological performance
Clinical characteristics of children of adult parents affected by Obsessive-compulsive disorder. dysfunctional beliefs and pattern of neuropsychological performance Open
View article: Age-related differences in cortical and subcortical volumetric changes in obsessive-compulsive disorder: an MRI study at two time points
Age-related differences in cortical and subcortical volumetric changes in obsessive-compulsive disorder: an MRI study at two time points Open
View article: White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group
White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group Open
View article: The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS
The genomics of visuospatial neurocognition in obsessive-compulsive disorder: A preliminary GWAS Open
Our results suggest that studying neurocognitive variables in GWAS would be more informative on the genetic basis of OCD than the classical case/control GWAS, facilitating the genetic characterization of OCD and its different clinical prof…
View article: Phenomenological characterisation of high-risk population for obsessive-compulsive disorder (OCD), comparative study of clinical, neuropsychological and dysfunctional beliefs of parents and their offspring
Phenomenological characterisation of high-risk population for obsessive-compulsive disorder (OCD), comparative study of clinical, neuropsychological and dysfunctional beliefs of parents and their offspring Open
View article: Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder Open
View article: Long-term comparative effectiveness of deep brain stimulation in severe obsessive-compulsive disorder
Long-term comparative effectiveness of deep brain stimulation in severe obsessive-compulsive disorder Open
View article: Viability Study of Machine Learning-Based Prediction of COVID-19 Pandemic Impact in Obsessive-Compulsive Disorder Patients
Viability Study of Machine Learning-Based Prediction of COVID-19 Pandemic Impact in Obsessive-Compulsive Disorder Patients Open
Background Machine learning modeling can provide valuable support in different areas of mental health, because it enables to make rapid predictions and therefore support the decision making, based on valuable data. However, few studies hav…
View article: Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder Open
View article: Long-Term Comparative Effectiveness of Deep Brain Stimulation in Severe Obsessive-Compulsive Disorder
Long-Term Comparative Effectiveness of Deep Brain Stimulation in Severe Obsessive-Compulsive Disorder Open
View article: Deep brain stimulation for obsessive-compulsive disorder: A systematic review of worldwide experience after 20 years
Deep brain stimulation for obsessive-compulsive disorder: A systematic review of worldwide experience after 20 years Open
The present review confirms that DBS is a promising therapy for patients with severe resistant OCD, providing both ST and LT evidence of efficacy.
View article: Childhood Maltreatment and Its Interaction with Hypothalamic–Pituitary–Adrenal Axis Activity and the Remission Status of Major Depression: Effects on Functionality and Quality of Life
Childhood Maltreatment and Its Interaction with Hypothalamic–Pituitary–Adrenal Axis Activity and the Remission Status of Major Depression: Effects on Functionality and Quality of Life Open
Relationships among childhood maltreatment (CM), hypothalamic-pituitary-adrenal (HPA) axis disturbances, major depressive disorder (MDD), poor functionality, and lower quality of life (QoL) in adulthood have been described. We aimed to stu…
View article: Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance El maltrato infantil interactúa con la retroalimentación negativa del eje hipotalámico-hipofisario-adrenal y la depresión mayor: efectos sobre el rendimiento cognitivo. 童年期虐待与下丘脑-垂体-肾上腺轴负反馈和重性抑郁障碍的相互作用:对认知表现的影响
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance El maltrato infantil interactúa con la retroalimentación negativa del eje hipotalámico-hipofisario-adrenal y la depresión mayor: efectos sobre el rendimiento cognitivo. 童年期虐待与下丘脑-垂体-肾上腺轴负反馈和重性抑郁障碍的相互作用:对认知表现的影响 Open
View article: Neurofunctional predictive biomarkers of cognitive-behavioral therapy during fear conditioning in patients with obsessive-compulsive disorder
Neurofunctional predictive biomarkers of cognitive-behavioral therapy during fear conditioning in patients with obsessive-compulsive disorder Open
Introduction Altered fear learning processes could be mechanistically linked to the development and/or maintenance of obsessive-compulsive disorder (OCD). From a clinical perspective, the first-line psychological treatment for OCD is cogni…
View article: First manic/hypomanic episode in obsessive-compulsive disorder patients treated with antidepressants: A systematic review
First manic/hypomanic episode in obsessive-compulsive disorder patients treated with antidepressants: A systematic review Open
High doses of antidepressants, particularly clomipramine and selective serotonin reuptake inhibitors (SSRIs), are the well-established treatment for obsessive-compulsive disorder (OCD), but manic/hypomanic episodes are potential adverse ev…
View article: Sleep disturbances in obsessive-compulsive disorder: influence of depression symptoms and trait anxiety
Sleep disturbances in obsessive-compulsive disorder: influence of depression symptoms and trait anxiety Open
View article: How is COVID-19 affecting patients with obsessive–compulsive disorder? A longitudinal study on the initial phase of the pandemic in a Spanish cohort
How is COVID-19 affecting patients with obsessive–compulsive disorder? A longitudinal study on the initial phase of the pandemic in a Spanish cohort Open
Background Although the consequences of the COVID-19 pandemic on emotional health are evident, little is known about its impact on patients with obsessive-compulsive disorder (OCD). Methods One hundred and twenty-seven patients with OCD wh…
View article: Vagus nerve stimulation as a potential modulator of periictal psychotic episodes: A report of four cases
Vagus nerve stimulation as a potential modulator of periictal psychotic episodes: A report of four cases Open
Drug resistant epilepsy (DRE) has been associated with a high incidence of psychotic disorders. Patients can develop psychosis after starting a new antiseizure medication, after undergoing resective surgery, or after implantation of a vagu…
View article: Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance Open
Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). …
View article: Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder Open
Although the etiology of obsessive-compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have…
View article: Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study
Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study Open
The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specifi…