Francesca Bertolini
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View article: Comparative analysis of targeted metabolomic profiles reveals plasma metabolite differences across three Italian heavy pig breeds
Comparative analysis of targeted metabolomic profiles reveals plasma metabolite differences across three Italian heavy pig breeds Open
In livestock, many economically important traits vary among breeds and lines, reflecting the influence of different genetic backgrounds on trait expression. In this study, we assessed how molecular phenotypes vary among three heavy pig bre…
View article: Accurate and rapid single nucleotide variation detection in PCSK9 gene using nanopore sequencing
Accurate and rapid single nucleotide variation detection in PCSK9 gene using nanopore sequencing Open
Background Genetic testing is essential for disease screening, diagnosis, prognosis, and pharmacotherapy guidance. Oxford Nanopore Technologies (ONT) offers a cost-effective platform for long-read sequencing, yet its routine use in clinica…
View article: Signatures of selection detected from whole‐genome sequencing indicate that the small body size in dwarf rabbit breeds is caused by polygenic effects with a few major loci
Signatures of selection detected from whole‐genome sequencing indicate that the small body size in dwarf rabbit breeds is caused by polygenic effects with a few major loci Open
Early genetic studies have suggested that body size in rabbits can be considered a quantitative trait. Several rabbit breeds can be distinguished based on body size, including a few dwarf breeds differentiated by other morphological charac…
View article: Comparing Morphometric and Mitochondrial DNA Data from Honeybees and Honey Samples for Identifying Apis mellifera ligustica Subspecies at the Colony Level
Comparing Morphometric and Mitochondrial DNA Data from Honeybees and Honey Samples for Identifying Apis mellifera ligustica Subspecies at the Colony Level Open
The ability to differentiate between different Apis mellifera subspecies can have significant implications for their conservation. In this study, we explored the possibility of obtaining multi-level information that could be useful in assi…
View article: Prognostic significance of early stage aortic valve disease development in heart failure: insights from the MECKI score cohort
Prognostic significance of early stage aortic valve disease development in heart failure: insights from the MECKI score cohort Open
Aims Heart failure (HF) continues to pose a major clinical challenge, making the identification of high-risk HF patients crucial for improving patient care, optimizing resource allocation, and streamlining healthcare processes. Among vario…
View article: Vascular remodeling and TSLP/angiogenin overexpression in severe mixed asthma
Vascular remodeling and TSLP/angiogenin overexpression in severe mixed asthma Open
Background Asthma with neutrophilic/mixed inflammation is a difficult-to-control clinical phenotype. Currently, vascular and matrix airway remodeling in asthma with neutrophilic/mixed inflammation is not well known. We aimed to evaluate th…
View article: Description of metabolic differences between castrated males and intact gilts obtained from high-throughput metabolomics of porcine plasma
Description of metabolic differences between castrated males and intact gilts obtained from high-throughput metabolomics of porcine plasma Open
Surgically castrated male pigs, which are commonly produced in pork production systems, have slightly lower production efficiency, compared to intact female pigs (gilts). This is mainly due to an unfavorable feed conversion rate and fatter…
View article: Immortalization of human valve interstitial cells: an<i>in vitro</i>tool for studying fibro-calcific aortic valve degeneration
Immortalization of human valve interstitial cells: an<i>in vitro</i>tool for studying fibro-calcific aortic valve degeneration Open
Human primary valve interstitial cells (VIC) are essential for studying the detrimental fibrocalcification processes typical of aortic valve degeneration. However, their limited lifespan poses a significant challenge. To address this, we i…
View article: The Role of Adiponectin and Leptin in Fibro-Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis
The Role of Adiponectin and Leptin in Fibro-Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis Open
Background: Fibro-calcific aortic valve disease (FCAVD) is a progressive disorder characterized by the thickening and calcification of the aortic valve, eventually leading to aortic stenosis. Adiponectin and leptin, known for their anti-in…
View article: Markers for egg quality in European eel derived from offspring of females subjected to different gonadotropic treatments
Markers for egg quality in European eel derived from offspring of females subjected to different gonadotropic treatments Open
Broodstock management techniques in general, and gonadotropic treatments for vitellogenesis induction in particular, can influence the maternal provisioning of different compounds to the eggs, thus affecting embryo and larval competence. A…
View article: Exploiting the anti-fibrotic effects of statins on thoracic aortic aneurysm progression: results from a meta-analysis and experimental data
Exploiting the anti-fibrotic effects of statins on thoracic aortic aneurysm progression: results from a meta-analysis and experimental data Open
Aims Thoracic aortic aneurysm (TAA) that progress to acute aortic dissection is often fatal and there is no pharmacological treatment that can reduce TAA progression. We aim to evaluate statins’ effects on TAA growth rate and outcomes usin…
View article: Non-stenotic aortic valve fibro-calcific content association with clinical outcomes in coronary artery disease patients
Non-stenotic aortic valve fibro-calcific content association with clinical outcomes in coronary artery disease patients Open
Background Aortic stenosis (AS) is the most common valve disorder, characterized by fibro-calcific remodeling of valve leaflets, which occurs even before hemodynamic changes. Progressive aortic valve calcification (AVC) leads to worse card…
View article: Identification of population‐informative markers from high‐density genotyping data through combined feature selection and machine learning algorithms: Application to European autochthonous and cosmopolitan pig breeds
Identification of population‐informative markers from high‐density genotyping data through combined feature selection and machine learning algorithms: Application to European autochthonous and cosmopolitan pig breeds Open
Large genotyping datasets, obtained from high‐density single nucleotide polymorphism (SNP) arrays, developed for different livestock species, can be used to describe and differentiate breeds or populations. To identify the most discriminat…
View article: Genome‐wide association studies for diarrhoea outcomes identified genomic regions affecting resistance to a severe enteropathy in suckling rabbits
Genome‐wide association studies for diarrhoea outcomes identified genomic regions affecting resistance to a severe enteropathy in suckling rabbits Open
Selection and breeding strategies to improve resistance to enteropathies are essential to reaching the sustainability of the rabbit production systems. However, disease heterogeneity (having only as major visible symptom diarrhoea) and low…
View article: Investigation of ABO Gene Variants across More Than 60 Pig Breeds and Populations and Other Suidae Species Using Whole-Genome Sequencing Datasets
Investigation of ABO Gene Variants across More Than 60 Pig Breeds and Populations and Other Suidae Species Using Whole-Genome Sequencing Datasets Open
Polymorphisms in the human ABO gene determine the major blood classification system based on the three well-known forms: A; B; and O. In pigs that carry only two main alleles in this gene (A and O), we still need to obtain a more comprehen…
View article: Comparative targeted metabolomic profiles of porcine plasma and serum
Comparative targeted metabolomic profiles of porcine plasma and serum Open
Supplementary Tables for: "Comparative targeted metabolomic profiles of porcine plasma and serum"
View article: The evolving story of catadromy in the European eel (<i>Anguilla anguilla</i>)
The evolving story of catadromy in the European eel (<i>Anguilla anguilla</i>) Open
Anguillid eels were once considered to be the classic example of catadromy. However, alternative life cycles have been reported, including skipping the freshwater phase and habitat shifting between fresh, brackish, and saltwater throughout…
View article: Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds
Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds Open
Following the recent domestication process of the European rabbit ( Oryctolagus cuniculus ), many different breeds and lines, distinguished primarily by exterior traits such as coat colour, fur structure and body size and shape, have been …
View article: Signatures of Admixture and Genetic Uniqueness in the Autochthonous Greek Black Pig Breed Deduced from Gene Polymorphisms Affecting Domestication-Derived Traits
Signatures of Admixture and Genetic Uniqueness in the Autochthonous Greek Black Pig Breed Deduced from Gene Polymorphisms Affecting Domestication-Derived Traits Open
The Greek Black Pig (or Greek Pig) is the only recognized autochthonous pig breed raised in Greece, usually in extensive or semi-extensive production systems. According to its name, the characteristic breed coat color is solid black. In th…