Renée Ventura‐Clapier
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View article: Modulation of cardiac cAMP signaling by AMPK and its adjustments in pressure overload-induced myocardial dysfunction in rat and mouse
Modulation of cardiac cAMP signaling by AMPK and its adjustments in pressure overload-induced myocardial dysfunction in rat and mouse Open
The beta-adrenergic system is a potent stimulus for enhancing cardiac output that may become deleterious when energy metabolism is compromised as in heart failure. We thus examined whether the AMP-activated protein kinase (AMPK) that is ac…
View article: Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?
Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? Open
Heart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has be…
View article: Energetic Interactions Between Subcellular Organelles in Striated Muscles
Energetic Interactions Between Subcellular Organelles in Striated Muscles Open
Adult striated muscle cells present highly organized structure with densely packed intracellular organelles and a very sparse cytosol accounting for only few percent of cell volume. These cells have a high and fluctuating energy demand tha…
View article: Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload
Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload Open
Heart failure is associated with profound alterations of energy metabolism thought to play a major role in the progression of this syndrome. SIRT1 is a metabolic sensor of cellular energy and exerts essential functions on energy metabolism…
View article: Estrogens, Estrogen Receptors Effects on Cardiac and Skeletal Muscle Mitochondria
Estrogens, Estrogen Receptors Effects on Cardiac and Skeletal Muscle Mitochondria Open
Mitochondria are unique organelles present in almost all cell types. They are involved not only in the supply of energy to the host cell, but also in multiple biochemical and biological processes like calcium homeostasis, production, and r…
View article: Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes
Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes Open
Our findings show that ER stress induces cytoarchitectural and metabolic alterations in cardiomyocytes and provide evidences that ER stress could represent a primary mechanism that contributes to the impairment of energy metabolism reporte…
View article: Maturation of Cardiac Energy Metabolism During Perinatal Development
Maturation of Cardiac Energy Metabolism During Perinatal Development Open
As one of the highest energy consumer organ in mammals, the heart has to be provided with a high amount of energy as soon as its first beats in utero. During the development of this organ, energy is produced within the cardiac muscle cell …
View article: Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation
Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation Open
Altered acetylation/deacetylation balance as the result of SIRT1 inactivation is involved in the pathogenesis of PAH, and this enzyme could be a promising therapeutic target for PAH treatment.
View article: Sex in basic research: concepts in the cardiovascular field
Sex in basic research: concepts in the cardiovascular field Open
Women and men, female and male animals and cells are biologically different, and acknowledgement of this fact is critical to advancing medicine. However, incorporating concepts of sex-specific analysis in basic research is largely neglecte…
View article: Mitochondria: a central target for sex differences in pathologies
Mitochondria: a central target for sex differences in pathologies Open
It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria are considered as the powerhouse of the cell because they produce the majorit…
View article: Ultrastructural remodelling of slow skeletal muscle fibres in creatine kinase deficient mice: a quantitative study
Ultrastructural remodelling of slow skeletal muscle fibres in creatine kinase deficient mice: a quantitative study Open
Creatine kinase content, isoform distribution, and participation in energy transfer are muscle type specific. We analysed ultrastructural changes in slow muscle fibres of soleus due to invalidation of creatine kinase (CK) to reveal a diffe…