Eberhard L. Renner
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View article: Trends in the incidence and prevalence of cirrhosis in Manitoba, Canada: A population-based study (2010-2019)
Trends in the incidence and prevalence of cirrhosis in Manitoba, Canada: A population-based study (2010-2019) Open
This population-based study highlights concerning temporal trends in cirrhosis, characterized by rising annual incidence and prevalence estimates, particularly among young adults and females. These findings underscore the urgent need for c…
View article: Identifying patients with diagnosed cirrhosis in administrative health databases: a validation study
Identifying patients with diagnosed cirrhosis in administrative health databases: a validation study Open
Objectives: Case ascertainment algorithms were developed and validated to identify people living with cirrhosis in administrative health data in Manitoba, Canada using primary care electronic medical records (EMR) to define the reference s…
View article: Development and validation of a case definition to estimate the prevalence and incidence of cirrhosis in pan-Canadian primary care databases
Development and validation of a case definition to estimate the prevalence and incidence of cirrhosis in pan-Canadian primary care databases Open
Aims: To develop and validate case definitions to identify patients with cirrhosis and alcohol-related cirrhosis using primary care electronic medical records (EMRs) and to estimate cirrhosis prevalence and incidence in pan-Canadian primar…
View article: Evaluation of a gene expression biomarker to identify operationally tolerant liver transplant recipients: the LITMUS trial
Evaluation of a gene expression biomarker to identify operationally tolerant liver transplant recipients: the LITMUS trial Open
LITMUS was a single-centre, Phase 2a study designed to investigate whether the gene biomarker FGL2/IFNG previously reported for the identification of tolerance in murine models could identify operationally tolerant liver transplant recipie…
View article: The Impact of Preexisting and Post-transplant Diabetes Mellitus on Outcomes Following Liver Transplantation
The Impact of Preexisting and Post-transplant Diabetes Mellitus on Outcomes Following Liver Transplantation Open
Background. Diabetes mellitus (DM) is said to adversely affect transplant outcomes. The aim of this study was to investigate the impact of pre-existing and new-onset DM on liver transplantation (LT) recipients. Methods. A single-center ret…
View article: A77 TRACKING WAIT TIMES AND OUTCOMES OF RADIOFREQUENCY ABLATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA: A QUALITY IMPROVEMENT INITIATIVE
A77 TRACKING WAIT TIMES AND OUTCOMES OF RADIOFREQUENCY ABLATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA: A QUALITY IMPROVEMENT INITIATIVE Open
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide.(1) Radiofrequency ablation (RFA) is the current recommended curative treatment option for non-surgical patien…
View article: Avoiding ICU Admission by Using a Fast-Track Protocol Is Safe in Selected Adult-to-Adult Live Donor Liver Transplant Recipients
Avoiding ICU Admission by Using a Fast-Track Protocol Is Safe in Selected Adult-to-Adult Live Donor Liver Transplant Recipients Open
Background We evaluated patient characteristics of live donor liver transplant (LDLT) recipients undergoing a fast-track protocol without intensive care unit (ICU) admission versus LDLT patients receiving posttransplant ICU care. Methods O…
View article: ICE volume 38 issue 9 Cover and Front matter
ICE volume 38 issue 9 Cover and Front matter Open
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View article: Wait Time for Curative Intent Radio Frequency Ablation is Associated with Increased Mortality in Patients with Early Stage Hepatocellular Carcinoma
Wait Time for Curative Intent Radio Frequency Ablation is Associated with Increased Mortality in Patients with Early Stage Hepatocellular Carcinoma Open
Incremental 30-day wait times are associated with a 9% increased risk of residual tumor and a 23% increased risk of death. We have identified system gaps where quality improvement measures can be implemented to reduce wait times and alloca…
View article: Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study
Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study Open
Whether and when recovery beyond the need for transplant may occur in patients listed for decompensation remains unclear. This study aimed to investigate the characteristics of patients delisted following recompensation. Seventy-seven pati…
View article: Identifying those infected with hepatitis C virus
Identifying those infected with hepatitis C virus Open
The new recommendations by the Canadian Task Force on Preventive Health Care for screening for hepatitis C virus (HCV) infection[1][1] strongly advise against screening those without apparent risks. This can only perpetuate Canada’s low HC…
View article: Early Intervention With Live Donor Liver Transplantation Reduces Resource Utilization in NASH: The Toronto Experience
Early Intervention With Live Donor Liver Transplantation Reduces Resource Utilization in NASH: The Toronto Experience Open
Background In parallel with the obesity epidemic, liver transplantation for nonalcoholic steatohepatitis (NASH) is increasing dramatically in North America. Although survival outcomes are similar to other etiologies, liver transplantation …
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
Acute liver failure due to secondary hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition and is considered by many as a contraindication for liver transplantation.The diagnosis is challenging and based on the …
View article: Donor BMI >30 Is Not a Contraindication for Live Liver Donation
Donor BMI >30 Is Not a Contraindication for Live Liver Donation Open
The increased prevalence of obesity worldwide threatens the pool of living liver donors. Although the negative effects of graft steatosis on liver donation and transplantation are well known, the impact of obesity in the absence of hepatic…
View article: Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation: First North American results
Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation: First North American results Open
The European trial investigating normothermic ex vivo liver perfusion (NEVLP) as a preservation technique for liver transplantation (LT) uses gelofusine, a non–US Food and Drug Administration–approved, bovine‐derived, gelatin‐based perfusi…
View article: Treatment with Optifast reduces hepatic steatosis and increases candidacy rates for living donor liver transplantation
Treatment with Optifast reduces hepatic steatosis and increases candidacy rates for living donor liver transplantation Open
Doyle, Adam M.B.B.S., B.Med.Sc., F.R.A.C.P.; Adeyi, Oyedele M.D., F.C.A.P., F.R.C.P.C.; Khalili, Korosh M.D., F.R.C.P.; Fischer, Sandra M.D.; Dib, Martin M.D.; Goldaracena, Nicolas M.D.; Dillon, Jayne M.B.B.S., M.R.C.P.; Grant, David M.D.,…
View article: The extended Toronto criteria for liver transplantation in patients with hepatocellular carcinoma: A prospective validation study
The extended Toronto criteria for liver transplantation in patients with hepatocellular carcinoma: A prospective validation study Open
The selection of liver transplant candidates with hepatocellular carcinoma (HCC) relies mostly on tumor size and number. Instead of relying on these factors, we used poor tumor differentiation and cancer‐related symptoms to exclude patient…
View article: Implication of the intestinal microbiome in complications of cirrhosis
Implication of the intestinal microbiome in complications of cirrhosis Open
The intestinal microbiome (IM) is altered in patients with cirrhosis, and emerging literature suggests that this impacts on the development of complications. The PubMed database was searched from January 2000 to May 2015 for studies and re…