E. Ricky Chan
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View article: Supplementary Figure 1 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Supplementary Figure 1 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs Open
S1. OSM induces tumor initiation.
View article: Supplementary Figure 4 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Supplementary Figure 4 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs Open
S4. OSM-expressing cells are distinct from CD44HI/mesenchymal cells created by EMT transcription factors.
View article: Supplementary Figure 3 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Supplementary Figure 3 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs Open
S3. Generation of OSMR knock-out cells.
View article: Supplementary Figure 6 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Supplementary Figure 6 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs Open
S6. Generation and analysis of SMAD3 knock-out cells.
View article: Supplementary Figure 2 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Supplementary Figure 2 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs Open
S2. Kaplan Meier comparison of IL-6 family member receptors.
View article: Supplementary Figure Legends 1-6 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Supplementary Figure Legends 1-6 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs Open
Supplementary Figure Legends 1-6
View article: Empowering prostate cancer survivors: Multidomain improvements and global implementation of a six-month patient activation program
Empowering prostate cancer survivors: Multidomain improvements and global implementation of a six-month patient activation program Open
View article: Epigenomic Interactions Between Chronic Pain and Recurrent Pressure Injuries After Spinal Cord Injury
Epigenomic Interactions Between Chronic Pain and Recurrent Pressure Injuries After Spinal Cord Injury Open
Background/Objectives: This study investigated variations in DNA methylation patterns associated with chronic pain and propensity for recurrent pressure injuries (PrI) in persons with spinal cord injury (SCI). Methods: Whole blood was coll…
View article: Macrophage–Kruppel-Like Transcription Factor 6 Signaling Promotes Experimental Atherogenesis
Macrophage–Kruppel-Like Transcription Factor 6 Signaling Promotes Experimental Atherogenesis Open
View article: Supplementary Figure S3 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S3 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S3. Immunophenotypic analysis of myeloid, B and T cells from bone marrow and splenic preps of Control or K2 KO 4T1 injected mice, two- and five-weeks following cell infusion.
View article: Supplementary Figure S2 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S2 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S2. K2 KO alters hematopoietic dynamics during D2A1 tumor progression.
View article: Supplementary Figure S4 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S4 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S4. Pathway analyses of the scRNA-seq data using Gene Ontology biological functions analyses.
View article: Supplementary Figure S6 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S6 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S6. mRNA co-expression of Kindlin-2 (FERMT2) and PD-L1 (CD274) in breast cancer tumors (n = 1,082 patients).
View article: Supplementary Figure S5 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S5 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S5. Heat map plot from the bulk RNA-seq analyses of the DEGs between the parental and Kindlin-2-KO 4T1 cells.
View article: Supplementary Table S1 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Table S1 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Table S1. Sequence of sgRNAs used for CRISPR/Cas9-mediated knockout of the genes involved in this study
View article: Supplementary Figure S7 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S7 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S7. Comparison of mRNA expression levels of PD-L1 (CD274) between the different breast Cancer molecular subtypes.
View article: Supplementary Figure S8 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S8 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S8. Gene Set Enrichment Analysis (GSEA) of RNA-seq data shows that Kindlin-2 expression levels correlate with gene signatures involved in Chemokine Signaling.
View article: Supplementary Table S2 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Table S2 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Table S2. Mouse antibodies panel for Akoya STEP multiplex immunostaining.
View article: Supplementary Figure S1 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figure S1 from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Supplementary Figure S1. Immunophenotypic analysis of myeloid, B and T cells from bone marrow and splenic preps of naïve, or 4T1 injected mice, two- and five-weeks following cell infusion.
View article: Data from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Data from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Triple-negative breast cancer (TNBC) presents significant clinical challenges because of its limited treatment options and aggressive behavior, often associated with poor prognosis. This study focuses on kindlin-2, an adapter protein, and …
View article: Supplementary Figures Legends from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
Supplementary Figures Legends from Kindlin-2–Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion Open
Legends for Supplementary Figures
View article: Impact of High‐Titer Convalescent Plasma on Clinical and Virologic Outcomes Among Veterans Hospitalized With SARS‐CoV‐2 Infection: VA CoronavirUs Research and Efficacy Studies‐1 (VA CURES‐1)
Impact of High‐Titer Convalescent Plasma on Clinical and Virologic Outcomes Among Veterans Hospitalized With SARS‐CoV‐2 Infection: VA CoronavirUs Research and Efficacy Studies‐1 (VA CURES‐1) Open
In the initial absence of proven therapies, empirical COVID‐19 convalescent plasma (CCP) was rapidly introduced for individuals hospitalized for COVID‐19. Seventy‐five participants were randomized from November 2020 to June 2021 in a doubl…
View article: PET imaging of hepatocellular carcinoma with [124I]IV-14
PET imaging of hepatocellular carcinoma with [124I]IV-14 Open
Our results demonstrate that UCK2 is a viable target for imaging HCC and has the potential for targeted endoradiotherapy of HCC.
View article: B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant
B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant Open
Background: Chemoresistance is an existing challenge faced in the treatment of the hairy cell leukemia variant (HCL-v). Classical hairy cell leukemia (HCL-c) is very sensitive to the standard of care with purine nucleoside analogs (PNAs) c…
View article: Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance
Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance Open
View article: Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia
Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia Open
Preterm neonates die at a significantly higher rate from sepsis than full-term neonates, attributable to their dysregulated immune response. In addition to tissue destruction caused directly by bacterial invasion, an overwhelming cytokine …
View article: Toll-Like receptor 3-mediated interferon-β production is suppressed by oncostatin m and a broader epithelial-mesenchymal transition program
Toll-Like receptor 3-mediated interferon-β production is suppressed by oncostatin m and a broader epithelial-mesenchymal transition program Open
Our findings provide a novel insight into the regulation of TLR3 and IFN-β production in TNBC cells, which are known indicators of treatment responses to DNA-damaging therapies. Furthermore, strategies to stimulate TLR3 in order to increas…
View article: Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models Open
The elevated level of replication stress is an intrinsic characteristic of cancer cells. Targeting the mechanisms that maintain genome stability to further increase replication stress and thus induce severe genome instability has become a …
View article: Importance of copy number variants in childhood apraxia of speech and other speech sound disorders
Importance of copy number variants in childhood apraxia of speech and other speech sound disorders Open
Childhood apraxia of speech (CAS) is a severe and rare form of speech sound disorder (SSD). CAS is typically sporadic, but may segregate in families with broader speech and language deficits. We hypothesize that genetic changes may be invo…
View article: Supplementary Figure 6 from Oncostatin-M and OSM-Receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs
Supplementary Figure 6 from Oncostatin-M and OSM-Receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs Open
S6. Generation and analysis of SMAD3 knock-out cells.