Luís Eduardo Paim Rohde
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View article: Regulated polarization of active particles in local osmotic flow fields
Regulated polarization of active particles in local osmotic flow fields Open
Regulation of a well-defined target state is essential for reliable functionality in living systems and maintaining non-equilibrium states. Controlling properties of microscale systems is particularly challenging due to thermal fluctuation…
View article: Prevalence and Mortality of Heart Failure Stages in a Free‐Living Older Adult Population: Data From the Brazilian Longitudinal Study of Adult Health
Prevalence and Mortality of Heart Failure Stages in a Free‐Living Older Adult Population: Data From the Brazilian Longitudinal Study of Adult Health Open
Background Heart failure (HF) has a major impact on public health. HF staging helps capture preclinical disease and its progression to advanced stages. There are scarce data on HF staging from longitudinal studies in Latin America. This st…
View article: Cost-Effectiveness of Mineralocorticoid Receptor Antagonists in Ischemic and Nonischemic Heart Failure With Reduced Ejection Fraction: Perspective From a Universal Healthcare System
Cost-Effectiveness of Mineralocorticoid Receptor Antagonists in Ischemic and Nonischemic Heart Failure With Reduced Ejection Fraction: Perspective From a Universal Healthcare System Open
Eplerenone is likely the most cost-effective MRA in Brazil considering individuals with both ischemic and nonischemic HFrEF.
View article: Adjunctive posterior wall isolation for patients with persistent atrial fibrillation: A systematic review and meta-analysis
Adjunctive posterior wall isolation for patients with persistent atrial fibrillation: A systematic review and meta-analysis Open
Our findings support that adjunctive PWI to PVI is an effective strategy compared with PVI alone for reducing ATA recurrence in patients with PeAF without compromising safety. Notably, patients with long-standing PeAF may benefit more from…
View article: Acute Heart Failure in Patients with Chagas Cardiomyopathy: Results of the I Brazilian Heart Failure Registry (BREATHE)
Acute Heart Failure in Patients with Chagas Cardiomyopathy: Results of the I Brazilian Heart Failure Registry (BREATHE) Open
Background Although the clinical features of chronic Chagas’ cardiomyopathy (CCC) have been well established, clinical data about the patients are scarce. Objectives The current analysis reports the results of the I Brazilian Heart Failure…
View article: The Southern Brazilian Registry of Atrial Fibrillation (SBR-AF Registry): Predictors of Atrial Arrhythmia Recurrence after First-Time Catheter Ablation
The Southern Brazilian Registry of Atrial Fibrillation (SBR-AF Registry): Predictors of Atrial Arrhythmia Recurrence after First-Time Catheter Ablation Open
Background Treatment of atrial fibrillation (AF) with catheter ablation (CA) has evolved significantly. However, real-world data on long-term outcomes are limited, particularly in low- and middle-income countries. Objective This multicente…
View article: Regulated polarization of active particles in local osmotic flow fields
Regulated polarization of active particles in local osmotic flow fields Open
Regulation to a well-defined target state is a fundamental requirement for achieving reliable functionality in living systems and maintaining specific non-equilibrium states. The control of certain properties and functionalities of systems…
View article: N-acetylcysteine increases total glutathione levels in experimental models of heart diseases: a systematic review and meta-analysis
N-acetylcysteine increases total glutathione levels in experimental models of heart diseases: a systematic review and meta-analysis Open
Background: Cardiovascular diseases (CVD) are the leading cause of death globally. Oxidative stress plays a significant role in cell damage, inflammation, and progression of CVD. The use of N-acetylcysteine (NAC), a well-known antioxidant …
View article: Cost-Utility of Venoarterial Extracorporeal Membrane Oxygenation in Refractory Cardiogenic Shock: A Brazilian Perspective Study
Cost-Utility of Venoarterial Extracorporeal Membrane Oxygenation in Refractory Cardiogenic Shock: A Brazilian Perspective Study Open
Background Refractory cardiogenic shock (CS) is associated with high mortality rates, and the use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) as a therapeutic option has generated discussions. Therefore, its cost-effectiv…
View article: Practitioner Review: Continuity of mental health care from childhood to adulthood for youths with ADHD – who, how and when?
Practitioner Review: Continuity of mental health care from childhood to adulthood for youths with ADHD – who, how and when? Open
Many youths with attention‐deficit/hyperactivity disorder (ADHD) experience significant long‐term impairment and may develop concurrent mental and somatic health difficulties as adults. This is associated with burden and costs for the indi…
View article: Growth/differentiation factor-15 (GDF-15) as a predictor of serious arrhythmic events in patients with nonischemic dilated cardiomyopathy
Growth/differentiation factor-15 (GDF-15) as a predictor of serious arrhythmic events in patients with nonischemic dilated cardiomyopathy Open
Introduction: Cardiac biomarkers have been proposed as a new tool to improve risk stratification of serious arrhythmic events in patients with heart failure (HF) beyond estimates of left ventricular ejection fraction. Growth differentiatio…
View article: Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy - 2024
Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy - 2024 Open
1. Introduction Scientific knowledge of hypertrophic cardiomyopathy (HCM) has significantly improved in the past decades. A better understanding of its pathogenesis, significant advances in the use of imaging methods, and the more common a…
View article: Multifaceted Strategy Based on Automated Text Messaging After a Recent Heart Failure Admission
Multifaceted Strategy Based on Automated Text Messaging After a Recent Heart Failure Admission Open
Importance Readmissions after an index heart failure (HF) hospitalization are a major contemporary health care problem. Objective To evaluate the feasibility and efficacy of an intensive telemonitoring strategy in the vulnerable period aft…
View article: Non‑synonymous polymorphisms in the <i>HRC</i> and <i>ADRB1</i> genes may be associated with all‑cause death in patients with non‑ischemic heart failure
Non‑synonymous polymorphisms in the <i>HRC</i> and <i>ADRB1</i> genes may be associated with all‑cause death in patients with non‑ischemic heart failure Open
Sudden cardiac death (SCD) is an unpredictable and common mode of death in patients with heart failure (HF). Alterations in calcium handling may lead to malignant arrhythmias, resulting in SCD, and variants in calcium signaling-related gen…
View article: Functional assessment based on cardiopulmonary exercise testing in mild heart failure: A multicentre study
Functional assessment based on cardiopulmonary exercise testing in mild heart failure: A multicentre study Open
Aims In this multicentre study, we compared cardio‐pulmonary exercise test (CPET) parameters between heart failure (HF) patients classified as New York Heart Association (NYHA) class I and II to assess NYHA performance and prognostic role …
View article: Left ventricular structural abnormalities in the assessment of diastolic function in the elderly: source of discrepancies between the 2009 and 2016 criteria
Left ventricular structural abnormalities in the assessment of diastolic function in the elderly: source of discrepancies between the 2009 and 2016 criteria Open
Purpose Diastolic dysfunction (DD) is routinely evaluated in echocardiography to support diagnosis, prognostication, and management of heart failure, a condition highly prevalent in elderly patients. Clinical guidelines were published in 2…
View article: Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction
Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction Open
Aims Few reports have examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) or their relationship with mortality in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or heart fail…
View article: Calcium signaling-related gene polymorphisms and prognosis of heart failure: genotype data from a retrospective cohort study
Calcium signaling-related gene polymorphisms and prognosis of heart failure: genotype data from a retrospective cohort study Open
Genotype data generated in a study that aimed to investigate whether the Ser96Ala (rs3745297; HRC), Ser49Gly (rs1801252; ADRB1), Arg389Gly (rs1801253; ADRB1) and Gly1886Ser (rs3766871; RYR2) polymorphisms were associated with serious arrhy…
View article: Brazilian Scientific Production about Cardiomyopathies: A Review from 2010 to 2022
Brazilian Scientific Production about Cardiomyopathies: A Review from 2010 to 2022 Open
By definition, myocardiopathies or cardiomyopathies (CM) are heart muscle diseases that cause structural and functional myocardial abnormalities in the absence of coronary artery disease, hypertension, valvular disease, and congenital hear…
View article: Associations Between New York Heart Association Classification, Objective Measures, and Long-term Prognosis in Mild Heart Failure
Associations Between New York Heart Association Classification, Objective Measures, and Long-term Prognosis in Mild Heart Failure Open
Importance Heart failure (HF) treatment recommendations are centered on New York Heart Association (NYHA) classification, such that most apparently asymptomatic patients are not eligible for disease-modifying therapies. Objectives To asses…
View article: Main results of the first Brazilian Registry of Heart Failure (BREATHE)
Main results of the first Brazilian Registry of Heart Failure (BREATHE) Open
Background Heart failure represents a common cause of hospitalization associated with poor short-term clinical outcomes. Little is known about the long-term prognosis of these patients in Latin America. Methods The rationale and design of …
View article: Is There Room for Sacubitril-Valsartan in the Treatment of Advanced Heart Failure?
Is There Room for Sacubitril-Valsartan in the Treatment of Advanced Heart Failure? Open
PARADIGM-HF, published in 2014, was a landmark in the modern pharmacological treatment of heart failure (HF). After several years and numerous clinical trials with disappointing results,– a new class of drugs was able to produce concrete r…
View article: Effect of sacubitril/valsartan on investigator‐reported ventricular arrhythmias in <scp>PARADIGM‐HF</scp>
Effect of sacubitril/valsartan on investigator‐reported ventricular arrhythmias in <span>PARADIGM‐HF</span> Open
Aims Sudden death is a leading cause of mortality in heart failure with reduced ejection fraction (HFrEF). In PARADIGM‐HF, sacubitril/valsartan reduced the incidence of sudden death. The purpose of this post hoc study was to analyse the ef…
View article: Reassessing the NYHA classification for heart failure: a comparison between classes I and II using cardiopulmonary exercise testing
Reassessing the NYHA classification for heart failure: a comparison between classes I and II using cardiopulmonary exercise testing Open
Background The New York Heart Association (NYHA) functional classification has evolved to become a major determinant of eligibility to medical interventions and clinical trials, but its reliability to discriminate patients with mild heart …
View article: Design of a multifaceted strategy based on automated text messaging in patients with recent heart failure admission
Design of a multifaceted strategy based on automated text messaging in patients with recent heart failure admission Open
Aims To evaluate a telemonitoring strategy based on automated text messaging and telephone support after heart failure (HF) hospitalization. Methods and results The MESSAGE‐HF study is a prospective multicentre, randomized, nationwide tria…
View article: Cardiac and Noncardiac Disease Burden and Treatment Effect of Sacubitril/Valsartan
Cardiac and Noncardiac Disease Burden and Treatment Effect of Sacubitril/Valsartan Open
Background: The net clinical benefit of cardiac disease-modifying drugs might be influenced by the interaction of different domains of disease burden. We assessed the relative contribution of cardiac, comorbid, and demographic factors in h…
View article: Dynamic changes in cardiovascular and systemic parameters prior to sudden cardiac death in heart failure with reduced ejection fraction: a <scp>PARADIGM‐HF</scp> analysis
Dynamic changes in cardiovascular and systemic parameters prior to sudden cardiac death in heart failure with reduced ejection fraction: a <span>PARADIGM‐HF</span> analysis Open
Aims Prognostic models of sudden cardiac death (SCD) typically incorporate data at only a single time‐point. We investigated independent predictors of SCD addressing the impact of integrating time‐varying covariates to improve prediction a…
View article: Impaired Right Ventricular Function in Heart Transplant Rejection
Impaired Right Ventricular Function in Heart Transplant Rejection Open
Background: The practice of screening for complications has provided high survival rates among heart transplantation (HTx) recipients. Objectives: Our aim was to assess whether changes in left ventricular (LV) and right ventricular (RV) gl…