Explanipedia

Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone Open

Imre Vörös, Zsófia Onódi, Viktória É. Tóth, Tamás G. Gergely, Éva Sághy , et al. · 2022

Dipeptidyl-peptidase-4 (DPP4) inhibitors are novel medicines for diabetes. The SAVOR-TIMI-53 clinical trial revealed increased heart-failure-associated hospitalization in saxagliptin-treated patients. Although this side effect could limit …

PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients Open

D. G. Szabó, Zsolt Sárszegi, Beáta Polgár, Éva Sághy, Dóra Reglődi , et al. · 2022

Pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) is a multifunctional neuropeptide, which may play a role in cardioprotection. However, little is known about the presence of PACAP-38 in heart failure (HF) patients. The aim …

Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection Open

Imre Vörös, Éva Sághy, Krisztina Pohóczky, András Makkos, Zsófia Onódi , et al. · 2021

Little is known about the role of the neuropeptide somatostatin (SST) in myocardial ischemia/reperfusion injury and cardioprotection. Here, we investigated the direct cardiocytoprotective effect of SST on ischemia/reperfusion injury in car…

PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study Open

D. G. Szabó, Zsolt Sárszegi, Beáta Polgár, Éva Sághy, Ádám Németh , et al. · 2021

Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The …

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation Open

Ádám Horváth, Maja Payrits, Anita Steib, Boglárka Kántás, Tünde Biró-Süt , et al. · 2021

Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-orde…

Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats Open

Valéria Tékus, Ádám Horváth, Kata Csekő, Krisztina Szabadfi, Andrea Kovács-Valasek , et al. · 2020

Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification Open

Maja Payrits, Ádám Horváth, Tünde Bíró-Sütő, János Erostyák, Géza Makkai , et al. · 2020

Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons and regulate nociceptor and inflammatory functions. Resolvins are endogenous lipid mediators. Resolv…

Ischaemic post‐conditioning in rats: Responder and non‐responder differ in transcriptome of mitochondrial proteins Open

Rolf Schreckenberg, Johann Klein, Hanna Sarah Kutsche, Rainer Schulz, Kamilla Gömöri , et al. · 2020

Ischaemic post‐conditioning (IPoC) is a clinical applicable procedure to reduce reperfusion injury. Non‐responsiveness to IPoC possibly caused by co‐morbidities limits its clinical attractiveness. We analysed differences in the expression …

Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes Open

Éva Sághy, Imre Vörös, Bence Ágg, Bernadett Kiss, Gábor Koncsos , et al. · 2020

Little is known about the mechanism of prediabetes-induced cardiac dysfunction. Therefore, we aimed to explore key molecular changes with transcriptomic and bioinformatics approaches in a prediabetes model showing heart failure with preser…

Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion Open

Gábor B. Brenner, András Makkos, Csilla Terézia Nagy, Zsófia Onódi, Nabil V. Sayour , et al. · 2020

Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of ‘hidden cardiotoxicity’ is defined as cardiotoxicity of a drug that manifests …

Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation Open

Éva Sághy, Maja Payrits, Tünde Bíró-Sütő, Rita Skoda‐Földes, Eszter Szánti‐Pintér , et al. · 2018

Estradiol Sensitizes the Transient Receptor Potential Vanilloid 1 Receptor in Pain Responses Open

Maja Payrits, Éva Sághy, Kata Csekő, Krisztina Pohóczky, Kata Bölcskei , et al. · 2017

Sex differences exist in chronic pain pathologies, and gonadal estradiol (E2) alters the pain sensation. The nocisensor transient receptor potential vanilloid 1 (TRPV1) receptor plays a critical role in triggering pain. Here we examined th…

CCDC 1054251: Experimental Crystal Structure Determination Open

Eszter Szánti‐Pintér, Johan Wouters, Ágnes Gömöry, Éva Sághy, Éva Szőke , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1054252: Experimental Crystal Structure Determination Open

Eszter Szánti‐Pintér, Johan Wouters, Ágnes Gömöry, Éva Sághy, Éva Szőke , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium Open

Krisztina Pohóczky, József Kun, Bálint Szalontai, Éva Szőke, Éva Sághy , et al. · 2015

Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors expressed predominantly in sensory nerves are activated by inflammatory stimuli and mediate inflammation and pain. Although they have been shown in the human …

CCDC 1054250: Experimental Crystal Structure Determination Open

Eszter Szánti‐Pintér, Johan Wouters, Ágnes Gömöry, Éva Sághy, Éva Szőke , et al. · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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