Edgar Schäfer
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View article: Melatonin and the Dental Pulp: A Scoping Review
Melatonin and the Dental Pulp: A Scoping Review Open
Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematical…
View article: Endodontic Re‐Surgery With Simultaneous Recession Coverage Using a Modified Flap Design After Failed Primary Apicoectomy: A Case Report
Endodontic Re‐Surgery With Simultaneous Recession Coverage Using a Modified Flap Design After Failed Primary Apicoectomy: A Case Report Open
Primarily, the present case report shows a coronal shift of the gingival margin after apicoectomy using a new modified coronally advanced flap. Secondly, by using Biodentine, complete bony healing was achieved without any bone substitutes.
View article: Radial Lands and Alternating Cutting Edges Contribute to Reduced Screw-in and Torque in Curved Root Canals - An In Vitro Study
Radial Lands and Alternating Cutting Edges Contribute to Reduced Screw-in and Torque in Curved Root Canals - An In Vitro Study Open
Radial lands or alternating cutting edges affect screw-in effect and torsional load of NiTi files.
View article: Enhancing severely compromised premolar strength: role of cusp reduction design in CAD/CAM composite restorations
Enhancing severely compromised premolar strength: role of cusp reduction design in CAD/CAM composite restorations Open
The objective of this study was to assess the effect of different designs and depths of cusp reduction on fracture resistance of maxillary permanent premolars restored with CAD/CAM composite restorations. A total of 42 sound maxillary prem…
View article: Endodontic diagnostics training in undergraduate dental education: An observational pilot study on AI‐driven virtual patient e‐learning
Endodontic diagnostics training in undergraduate dental education: An observational pilot study on AI‐driven virtual patient e‐learning Open
Aim To develop and evaluate an e‐learning tool utilizing a generative pre‐trained transformer (GPT), a form of artificial intelligence (AI), to allow for realistic conversation on virtual patients when undergoing training on how to diagnos…
View article: Cytocompatibility, osteogenic potential, antibacterial and antibiofilm efficacy of a calcium-silicate-based intracanal medication
Cytocompatibility, osteogenic potential, antibacterial and antibiofilm efficacy of a calcium-silicate-based intracanal medication Open
This study assessed the biological and antimicrobial properties of a calcium silicate-based material and calcium hydroxide (CH) when used as intracanal medications. MTT assay, osteogenic differentiation of human periodontal stem cells (hPD…
View article: A Methodological Study on Microbial In Vivo Sampling Methods of Root Canal Microbiota for Next-Generation Gene Sequencing Analysis
A Methodological Study on Microbial In Vivo Sampling Methods of Root Canal Microbiota for Next-Generation Gene Sequencing Analysis Open
Paper point and endodontic instrument sampling generate valid specimens for 16S rDNA community profiling. Endodontic instrument sampling is easier to execute and, therefore, could be the technique of choice.
View article: Cytocompatibility, Antibacterial, and Anti-Biofilm Efficacy of Grape Seed Extract and Quercetin Hydrogels Against a Mature Endodontic Biofilm Ex Vivo Model
Cytocompatibility, Antibacterial, and Anti-Biofilm Efficacy of Grape Seed Extract and Quercetin Hydrogels Against a Mature Endodontic Biofilm Ex Vivo Model Open
Background/Objectives: To assess the cytocompatibility, antibacterial and anti-biofilm efficacy of grape seed extract (GSE) and quercetin hydrogels versus calcium hydroxide (CH) as intracanal medications (ICMs) against an endodontic ex viv…
View article: Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial
Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial Open
Objectives This 2-part randomized parallel triple-blind clinical trial adopts a unique model assessing clinically-set hydraulic calcium silicate-based sealers (HCSBS) after different root canal dryness protocols and obturation techniques. …
View article: Prevalence of multiple roots and complex canal morphology in mandibular premolars among a selected Southern Egyptian sub-population: a CBCT-analysis
Prevalence of multiple roots and complex canal morphology in mandibular premolars among a selected Southern Egyptian sub-population: a CBCT-analysis Open
The mandibular premolars can pose a significant challenge in root canal treatment due to their complex canal system. This study investigated the prevalence of multiple roots and complex canal morphology of mandibular premolars in a selecte…
View article: An AI‐based e‐learning tool to improve endodontic diagnostics in undergraduate students
An AI‐based e‐learning tool to improve endodontic diagnostics in undergraduate students Open
Undergraduate students often lack experience in diagnosing dental pain, especially in those cases with pulpal involvement and a need for endodontic treatment. Not all university dental clinics provide participation of the students in provi…
View article: Cyclic Fatigue of Different Reciprocating Endodontic Instruments Using Matching Artificial Root Canals at Body Temperature In Vitro
Cyclic Fatigue of Different Reciprocating Endodontic Instruments Using Matching Artificial Root Canals at Body Temperature In Vitro Open
Reciprocating motion expands the lifetime of endodontic instruments during the preparation of severely curved root canals. This study aimed to investigate the time to fracture (TTF) and number of cycles to failure (NCF) of different recipr…
View article: Influence of pulse energy, tip design and insertion depth during Er:<scp>YAG</scp>‐activated irrigation on cleaning efficacy in simulated severely curved complex root canal systems <i>in vitro</i>
Influence of pulse energy, tip design and insertion depth during Er:<span>YAG</span>‐activated irrigation on cleaning efficacy in simulated severely curved complex root canal systems <i>in vitro</i> Open
Aim To investigate the influence of pulse energy, tip geometry and tip position in simulated 3D‐printed root canals with multiple side canals at different levels in all directions on the cleaning performance of laser‐activated irrigation (…
View article: Resolution of a periapical lesion in an autoimmune pancreatitis patient treated with long-term low-dose glucocorticoids: a case report
Resolution of a periapical lesion in an autoimmune pancreatitis patient treated with long-term low-dose glucocorticoids: a case report Open
Background Patients diagnosed with an autoimmune disease are often systemically medicated with glucocorticoids. Autoimmune pancreatitis (AIP) Type 1 is considered a rare autoimmune disease, which is very well responsive to glucocorticoids …
View article: Effect of Different Sealers on the Cytocompatibility and Osteogenic Potential of Human Periodontal Ligament Stem Cells: An In Vitro Study
Effect of Different Sealers on the Cytocompatibility and Osteogenic Potential of Human Periodontal Ligament Stem Cells: An In Vitro Study Open
Background: There is tendency for unavoidable sealer extrusion in some clinical cases. This might adversely affect host stem cells and affect healing. This study aimed to investigate the effect of different sealers on the cytocompatibility…
View article: Short and Long-Term Solubility, Alkalizing Effect, and Thermal Persistence of Premixed Calcium Silicate-Based Sealers: AH Plus Bioceramic Sealer vs. Total Fill BC Sealer
Short and Long-Term Solubility, Alkalizing Effect, and Thermal Persistence of Premixed Calcium Silicate-Based Sealers: AH Plus Bioceramic Sealer vs. Total Fill BC Sealer Open
This study aimed to investigate the short- and long-term solubility, alkalizing potential, and suitability for warm-vertical compaction of AH Plus Bioceramic Sealer (AHBC), and Total Fill BC Sealer (TFBC) compared to the epoxy-resin sealer…
View article: Human Primary Odontoblast-like Cell Cultures—A Focused Review Regarding Cell Characterization
Human Primary Odontoblast-like Cell Cultures—A Focused Review Regarding Cell Characterization Open
Cell cultures can provide useful in vitro models. Since odontoblasts are postmitotic cells, they cannot be expanded in cell cultures. Due to their extension into the dentin, injuries are inevitable during isolation. Therefore, “odontoblast…
View article: Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin
Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin Open
The circulating low-density lipoprotein concentration in blood can be reduced by the administration of statins. Frequently simvastatin (SV) is prescribed. Due to the reported pleiotropic effects of SV the aim of this study was to evaluate …
View article: Effectiveness of diagnosing pulpitis: A systematic review
Effectiveness of diagnosing pulpitis: A systematic review Open
Background The diagnosis of the status of the inflamed pulp is essential in clinical diagnosis and treatment provision. There are a limited number of well‐designed and well‐executed clinical trials on the diagnosis of the true status of th…
View article: Effect of Core Mass and Alloy on Cyclic Fatigue Resistance of Different Nickel-Titanium Endodontic Instruments in Matching Artificial Canals
Effect of Core Mass and Alloy on Cyclic Fatigue Resistance of Different Nickel-Titanium Endodontic Instruments in Matching Artificial Canals Open
Instrument failure during root canal preparation is still a concern among endodontists. However, it remains unclear whether the use of more martensitic alloys or the cross-sectional design parameters (i.e., core mass) significantly improve…
View article: Minimal Dentinal Tubule Penetration of Endodontic Sealers in Warm Vertical Compaction by Direct Detection via SEM Analysis
Minimal Dentinal Tubule Penetration of Endodontic Sealers in Warm Vertical Compaction by Direct Detection via SEM Analysis Open
Sealer staining using rhodamine B dye to investigate the penetration depth of endodontic sealers was proven unsuitable for this purpose. This study aimed to investigate the sealer penetration depth into dentinal tubules by scanning electro…
View article: Influence of Root Canal Fillings on Alveolar Bone Crest Level—An Observational Cross Sectional CBCT Analysis
Influence of Root Canal Fillings on Alveolar Bone Crest Level—An Observational Cross Sectional CBCT Analysis Open
The aim of this study was to compare the alveolar bone crest (ABC) level of root canal filled (RCF) teeth without apical periodontitis with corresponding non-filled teeth in the same individual using three-dimensionally cone-beam computed …
View article: Debunking the Concept of Dentinal Tubule Penetration of Endodontic Sealers: Sealer Staining with Rhodamine B Fluorescent Dye Is an Inadequate Method
Debunking the Concept of Dentinal Tubule Penetration of Endodontic Sealers: Sealer Staining with Rhodamine B Fluorescent Dye Is an Inadequate Method Open
The aim of this study was to investigate the suitability of rhodamine B dye staining of an epoxy resin sealer (AH Plus) and calcium-silicate-based sealers (Total Fill BC Sealer, BioRoot RCS) to represent the penetration depth of the sealer…
View article: Need for Standardization: Influence of Artificial Canal Size on Cyclic Fatigue Tests of Endodontic Instruments
Need for Standardization: Influence of Artificial Canal Size on Cyclic Fatigue Tests of Endodontic Instruments Open
The aim was to evaluate the influence of artificial canal size on the results of cyclic fatigue tests for endodontic instruments. Dynamic cyclic fatigue at body temperature using continuous tapered nickel–titanium F6-SkyTaper instruments (…
View article: Shaping Ability and Debris Extrusion of New Rotary Nickel-Titanium Root Canal Instruments
Shaping Ability and Debris Extrusion of New Rotary Nickel-Titanium Root Canal Instruments Open
The aim was to evaluate the canal straightening and the amount of apically extruded debris associated with five rotary nickel-titanium when preparing curved root canals. A total of 100 root canals in extracted human teeth (angles of curvat…
View article: Physico-Chemical Investigation of Endodontic Sealers Exposed to Simulated Intracanal Heat Application: Hydraulic Calcium Silicate-Based Sealers
Physico-Chemical Investigation of Endodontic Sealers Exposed to Simulated Intracanal Heat Application: Hydraulic Calcium Silicate-Based Sealers Open
The aim of this study was to gain information about the effect of thermal treatment of calcium silicate-based sealers. BioRoot RCS (BR), Total Fill BC Sealer (TFBC), and Total Fill BC Sealer HiFlow (TFHF) were exposed to thermal treatment …