Karen E. Shattuck
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View article: Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants
Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants Open
Clindamycin may be active against methicillin-resistant Staphylococcus aureus , a common pathogen causing sepsis in infants, but optimal dosing in this population is unknown. We performed a multicenter, prospective pharmacokinetic (PK) and…
View article: Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants
Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants Open
Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scal…
View article: Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants
Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants Open
Objectives Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. We sought to better…
View article: Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants
Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants Open
Clindamycin may be active against methicillin-resistant Staphylococcus aureus , a common pathogen causing sepsis in infants, but optimal dosing in this population is unknown. We performed a multicenter, prospective pharmacokinetic (PK) and…