Eiji Miyoshi
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View article: Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders
Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders Open
Background Steatotic liver disease (SLD) is a hepatic phenotype of metabolic syndrome (MetS). However, little is known about the relationship between SLD and the onset of each MetS‐related disease (type 2 diabetes [T2D], hypertension, and …
View article: Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes
Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes Open
Core fucose is one of the most important glycans in HBV infection. In this study, we investigated whether Pholiota squarrosa lectin (PhoSL), a lectin that specifically binds to core fucose, exerts an inhibitory effect in an HBV infection m…
View article: Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes
Potential for Core Fucose-Targeted Therapy Against HBV Infection of Human Normal Hepatocytes Open
Core fucose is one of the most important glycans in HBV infection. In this study, we investigated whether PhoSL, a lectin that specifically binds to core fucose, exerts an inhibitory effect in an HBV infection model of normal human hepatoc…
View article: Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study
Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study Open
Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. Despite extensive research on Hp glycosylation as a glyco-biomarker for cancers, underst…
View article: Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A
Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A Open
The poor prognosis of pancreatic cancer is often attributed to difficulties of early detection due to a lack of appropriate risk factors. Previously, we demonstrated the presence of Enterococcus faecalis (E. faecalis) in pancreatic juice a…
View article: Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction–associated steatotic liver disease
Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction–associated steatotic liver disease Open
Background: Various noninvasive tests can be used to identify high-risk groups of patients with metabolic dysfunction–associated steatotic liver disease/steatohepatitis (MASLD). In this study, we compared the diagnostic performance of seru…
View article: Inside Cover: Development of a FUT8 Inhibitor with Cellular Inhibitory Properties (Angew. Chem. Int. Ed. 52/2024)
Inside Cover: Development of a FUT8 Inhibitor with Cellular Inhibitory Properties (Angew. Chem. Int. Ed. 52/2024) Open
View article: Development of a FUT8 Inhibitor with Cellular Inhibitory Properties
Development of a FUT8 Inhibitor with Cellular Inhibitory Properties Open
Core fucosylation is catalyzed by α‐1,6‐fucosyltransferase (FUT8), which fucosylates the innermost GlcNAc of N ‐glycans. Given the association of FUT8 with various diseases, including cancer, selective FUT8 inhibitors applicable to in vivo…
View article: Development of a FUT8 Inhibitor with Cellular Inhibitory Properties
Development of a FUT8 Inhibitor with Cellular Inhibitory Properties Open
Core fucosylation is catalyzed by α‐1,6‐fucosyltransferase (FUT8), which fucosylates the innermost GlcNAc of N ‐glycans. Given the association of FUT8 with various diseases, including cancer, selective FUT8 inhibitors applicable to in vivo…
View article: Dynamic movement of the Golgi unit and its glycosylation enzyme zones
Dynamic movement of the Golgi unit and its glycosylation enzyme zones Open
View article: Serum levels of the N-terminal fragment of connective tissue growth factor is a novel biomarker for chronic pancreatitis
Serum levels of the N-terminal fragment of connective tissue growth factor is a novel biomarker for chronic pancreatitis Open
View article: The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells
The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells Open
Dendritic cells, macrophages, neutrophils, and other antigen-presenting cells express various C-type lectin receptors that function to recognize the glycans associated with pathogens. The dendritic cell-specific intercellular adhesion mole…
View article: Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors
Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors Open
Glycans control various biological processes, depending on their structures. Particularly, core fucose, formed by α1,6-fucosyltransferase (FUT8), has a substantial influence on multiple biological processes. In this study, we investigated …
View article: Prognostic significance of serum fucosylated pro-haptoglobin in advanced renal cell carcinoma patients treated with immune checkpoint inhibitors
Prognostic significance of serum fucosylated pro-haptoglobin in advanced renal cell carcinoma patients treated with immune checkpoint inhibitors Open
With the widespread use of immune checkpoint inhibitors (ICIs), identifying predictive biomarkers is critical. Recently, serum fucosylated haptoglobin (Fuc-Hp) was thought to play an important role in tumour immunity in several types of ca…
View article: Development of new colloid osmotic pressure measurement method using ultrafiltration membrane during cardiopulmonary bypass
Development of new colloid osmotic pressure measurement method using ultrafiltration membrane during cardiopulmonary bypass Open
Background : Clinical practice of measuring colloid osmotic pressure (COP) was abandoned after correcting hypoosmolarity did not improve overall patient outcomes. However, the use of albumin and colloidal solutions has contributed to maint…
View article: Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells Open
Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy. How mannose exerts its anticancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cel…
View article: Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression
Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression Open
Background Cholangiocarcinoma (CCA) is a silent tumor with a high mortality rate due to the difficulty of early diagnosis and prediction of recurrence even after timely surgery. Serologic cancer biomarkers have been used in clinical practi…
View article: The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro
The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro Open
Glycosylation of proteins and lipids in viruses and their host cells is important for viral infection and is a target for antiviral therapy. Hepatitis B virus (HBV) is a major pathogen that causes acute and chronic hepatitis; it cannot be …
View article: Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors
Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors Open
Background: Hepatocyte sources that are expandable in vitro are required for liver regenerative medicine and to elucidate the mechanisms underlying the physiological functions of the liver. Liver ductal organoids (LDOs) comprise liver tiss…
View article: EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts
EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts Open
Cell polarity, the asymmetric distribution of proteins and organelles, is permanently or transiently established in various cell types and plays an important role in many physiological events. epidermal growth factor receptor substrate 15 …
View article: Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells
Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells Open
Fucosylated proteins are widely used as biomarkers of cancer and inflammation. Fucosylated alpha-fetoprotein (AFP-L3) is a specific biomarker for hepatocellular carcinoma. We previously showed that increases in serum AFP-L3 levels depend o…
View article: Data from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue
Data from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue Open
Background: Alterations in glycosylation have long been associated with the development of cancer. In the case of primary hepatocellular carcinoma (HCC), one alteration that has often been associated is increased amounts of fucose a…
View article: Supplementary Figure 1 from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue
Supplementary Figure 1 from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue Open
PDF file, 354KB, N-linked glycosylation of total protein from 16 HCC tissue and adjacent liver tissue pairs.
View article: Supplementary Figure 1 from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue
Supplementary Figure 1 from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue Open
PDF file, 354KB, N-linked glycosylation of total protein from 16 HCC tissue and adjacent liver tissue pairs.
View article: Data from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue
Data from Increased Levels of Tetra-antennary <i>N</i>-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue Open
Background: Alterations in glycosylation have long been associated with the development of cancer. In the case of primary hepatocellular carcinoma (HCC), one alteration that has often been associated is increased amounts of fucose a…
View article: Supplementary Methods from Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer
Supplementary Methods from Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer Open
Supplementary Methods from Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer
View article: Supplementary Figure 1 from Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer
Supplementary Figure 1 from Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer Open
Supplementary Figure 1 from Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer
View article: Supplementary Table 1 from The Asn<sup>418</sup>-Linked <i>N</i>-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
Supplementary Table 1 from The Asn<sup>418</sup>-Linked <i>N</i>-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion Open
Supplementary Table 1 from The Asn418-Linked N-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
View article: Supplementary Figure 1 from The Asn<sup>418</sup>-Linked <i>N</i>-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
Supplementary Figure 1 from The Asn<sup>418</sup>-Linked <i>N</i>-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion Open
Supplementary Figure 1 from The Asn418-Linked N-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
View article: Data from The Asn<sup>418</sup>-Linked <i>N</i>-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion
Data from The Asn<sup>418</sup>-Linked <i>N</i>-Glycan of ErbB3 Plays a Crucial Role in Preventing Spontaneous Heterodimerization and Tumor Promotion Open
ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence…