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View article: Lung function abnormalities in Singapore: a population-based cohort study on preserved ratio impaired spirometry and undiagnosed airway disease
Lung function abnormalities in Singapore: a population-based cohort study on preserved ratio impaired spirometry and undiagnosed airway disease Open
Introduction: Data on lung function abnormalities in Singapore are limited. Preserved ratio impaired spirometry (PRISm) and undiagnosed obstructive airway disease (UAD) are frequently overlooked conditions associated with worsened respirat…
View article: Metabolic impact of dietary glycine supplementation in individuals with severe obesity
Metabolic impact of dietary glycine supplementation in individuals with severe obesity Open
View article: Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues
Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues Open
Weight loss through exercise and diet reduces the risk of type 2 diabetes, but the genetic regulation of gene expression and splicing in response to weight loss remains unclear in humans. We collected clinical data and skeletal muscle biop…
View article: Acceptance and feasibility of novel staple foods among individuals with type 2 diabetes in Singapore: a mixed methods study
Acceptance and feasibility of novel staple foods among individuals with type 2 diabetes in Singapore: a mixed methods study Open
Introduction Novel staple foods (NVSFs) are defined as modified staple foods that provide healthier alternatives to type 2 diabetes (T2D) patients aiming to improve postprandial glycemic responses. We explored the expectations and percepti…
View article: LvL UP 1.0, a holistic mHealth lifestyle coaching intervention for the prevention of non-communicable diseases and common mental disorders: a mixed methods feasibility study
LvL UP 1.0, a holistic mHealth lifestyle coaching intervention for the prevention of non-communicable diseases and common mental disorders: a mixed methods feasibility study Open
LvL UP is a smartphone-based holistic lifestyle coaching intervention aimed at improving health behaviours, mental well-being, and preventing noncommunicable diseases and common mental disorders. It features a ‘talk and tools’ approach, co…
View article: Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection
Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection Open
This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.
View article: National Scale Genomic Engine for Precision Medicine: Singapore PRECISE-SG100K Experience
National Scale Genomic Engine for Precision Medicine: Singapore PRECISE-SG100K Experience Open
Precision medicine (PM) research in recent years has witnessed a remarkable surge in large-scale population genomics programs. In 2017, Singapore initiated the National Precision Medicine (NPM) program, a three-phase national strategy driv…
View article: The LvL UP trial: Protocol for a sequential, multiple assignment, randomised controlled trial to assess the effectiveness of a blended mobile lifestyle intervention
The LvL UP trial: Protocol for a sequential, multiple assignment, randomised controlled trial to assess the effectiveness of a blended mobile lifestyle intervention Open
The LvL UP Pilot trial was prospectively registered with ClinicalTrials.gov (NCT06360029).
View article: Understanding and overcoming barriers to digital health adoption: a patient and public involvement study
Understanding and overcoming barriers to digital health adoption: a patient and public involvement study Open
Background Digital health (DH) technologies provide scalable and cost-effective solutions to improve population health but face challenges of uneven adoption and high attrition, particularly among vulnerable and minority groups. Purpose Th…
View article: Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population Open
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to 1) evaluate the associations between BMI, waist circumference (WC), and ∼5,000 plasma proteins (SomaScan V4), 2) identify protein signatur…
View article: Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population
Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population Open
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to (i) evaluate the associations between body mass index (BMI), waist circumference (WC), and ~5,000 plasma proteins (SomaScan v4), (ii) iden…
View article: Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population
Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population Open
The biomarkers connecting obesity and cardiometabolic diseases are not fully understood. We aimed to (i) evaluate the associations between body mass index (BMI), waist circumference (WC), and ~5,000 plasma proteins (SomaScan v4), (ii) iden…
View article: The behavioral mechanisms that underpin the adoption of digital health interventions by a diverse multicultural population: a patient and public involvement study
The behavioral mechanisms that underpin the adoption of digital health interventions by a diverse multicultural population: a patient and public involvement study Open
Purpose: Digital health interventions (DHIs) offer scalable and cost-effective solutions for preventive healthcare, yet their adoption remains uneven, particularly among vulnerable and minority groups. High attrition rates also challenge t…
View article: Omeprazole and cardiovascular risk via induction of statin dysmetabolism
Omeprazole and cardiovascular risk via induction of statin dysmetabolism Open
Background Statins are a first line treatment for reducing cardiovascular risk. While drug-drug interactions which cause symptomatic side effects are well known, drug- drug interactions which decrease statin effectiveness are poorly unders…
View article: Effects of night-to-night variations in objectively measured sleep on blood glucose in healthy university students
Effects of night-to-night variations in objectively measured sleep on blood glucose in healthy university students Open
Study Objectives We examined associations between daily variations in objectively measured sleep and blood glucose in a sample of non-diabetic young adults to complement laboratory studies on how sleep affects blood glucose levels. Methods…
View article: Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore
Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore Open
View article: Codesigning a Digital Type 2 Diabetes Risk Communication Tool in Singapore: Qualitative Participatory Action Research Approach
Codesigning a Digital Type 2 Diabetes Risk Communication Tool in Singapore: Qualitative Participatory Action Research Approach Open
Background Diabetes is a serious public health concern worldwide. Despite public health efforts encouraging early screening and improving knowledge of effective interventions for those at increased risk of type 2 diabetes (T2D), the incorp…
View article: Statin Lactone Metabolism is a Determinant of 5-year Cardiovascular Outcomes Independent of Serum Cholesterol
Statin Lactone Metabolism is a Determinant of 5-year Cardiovascular Outcomes Independent of Serum Cholesterol Open
Statins are a first line treatment for reducing cardiovascular risk, however the individual clinical benefit of statins remains highly variable. To understand the clinical impact of individual statin metabolites on long-term clinical outco…
View article: The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway
The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway Open
Background Glycine is an integral component of the human detoxification system as it reacts with potentially toxic exogenous and endogenously produced compounds and metabolites via the glycine conjugation pathway for urinary excretion. Bec…
View article: WCN24-1538 UTILITY OF PROTEIN BIOMARKERS IN URINARY EXOSOMES AND WHOLE URINE FOR RISK STRATIFICATION OF DIABETIC KIDNEY DISEASE PROGRESSION
WCN24-1538 UTILITY OF PROTEIN BIOMARKERS IN URINARY EXOSOMES AND WHOLE URINE FOR RISK STRATIFICATION OF DIABETIC KIDNEY DISEASE PROGRESSION Open
Currently, monitoring the levels of albuminuria/proteinuria remains the only method of diabetic kidney disease (DKD) risk stratification in clinical practice. Urinary exosomes (UEs) have been evaluated as a potential non-invasive biomarker…
View article: Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure
Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure Open
BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP. METHODS: We analyzed up to 9 420 585 single…
View article: Patient perspectives of diabetes care in primary care networks in Singapore: a mixed-methods study
Patient perspectives of diabetes care in primary care networks in Singapore: a mixed-methods study Open
View article: Associations of childhood and current secondhand smokeexposure at home with current secondhand smoke exposureat work: A cross-sectional analysis of the Singapore multiethniccohort
Associations of childhood and current secondhand smokeexposure at home with current secondhand smoke exposureat work: A cross-sectional analysis of the Singapore multiethniccohort Open
Current SHSEhome was a risk factor for current SHSEwork, with risks elevated among those who smoke daily at home and living with their children. Childhood SHSEhome becomes a risk factor when daily household…
View article: Mindsets and self-efficacy beliefs among individuals with type 2 diabetes
Mindsets and self-efficacy beliefs among individuals with type 2 diabetes Open
View article: Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure
Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure Open
Objective We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP). Methods We analyzed up to 9,420,585 biallelic imputed single nucleotide polym…
View article: Personalised care and support planning in Singapore: qualitative interviews with people living with diabetes
Personalised care and support planning in Singapore: qualitative interviews with people living with diabetes Open
Background Personalised care and support planning (CSP) is a person-centred approach for the care of people living with long-term conditions. Patient Activation through Community Empowerment/Engagement for Diabetes Management (PACE-D) adap…
View article: Postprandial glycemic and lipidemic effects of black rice anthocyanin extract fortification in foods of varying macronutrient compositions and matrices
Postprandial glycemic and lipidemic effects of black rice anthocyanin extract fortification in foods of varying macronutrient compositions and matrices Open
Anthocyanin (ACN) fortification of commonly consumed foods is significant as a dietary strategy against the development of metabolic complications by delivering ACNs at high doses. However, its bioactivity and translated metabolic effects …
View article: A fully convolutional neural network for comprehensive compartmentalization of abdominal adipose tissue compartments in MRI
A fully convolutional neural network for comprehensive compartmentalization of abdominal adipose tissue compartments in MRI Open
View article: A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes Open
Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little kn…
View article: Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy
Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy Open
Significance Statement Genome-wide association studies have identified nearly 20 IgA nephropathy susceptibility loci. However, most nonsynonymous coding variants, particularly ones that occur rarely or at a low frequency, have not been wel…