Edmond S.K.
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View article: ADGL-07 GLIOBLASTOMAS IN TOGO : EPIDEMIOLOGY, MANAGEMENT AND CHALLENGES IN A COUNTRY WITH LIMITED RESOURCES
ADGL-07 GLIOBLASTOMAS IN TOGO : EPIDEMIOLOGY, MANAGEMENT AND CHALLENGES IN A COUNTRY WITH LIMITED RESOURCES Open
Summary Introduction Glioblastoma (GBM) is the most common malignant brain tumor in adults. Its management is complex, and even more difficult in developing countries due to the scarcity of diagnostic and therapeutic resources. Patients an…
View article: Germline BARD1 Mutation in High-Risk Chinese Breast and Ovarian Cancer Patients
Germline BARD1 Mutation in High-Risk Chinese Breast and Ovarian Cancer Patients Open
Background: The prevalence of BARD1 mutations in breast and ovarian cancers varies across different ethnic groups. Evaluating the cancer risk and clinical significance of BARD1 mutations in the local Chinese patients with breast cancer, ov…
View article: Supplementary Data S2 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Data S2 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Data S2. Nanopore sequencing.
View article: Supplementary Data S3 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Data S3 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Data S3. scRNA-seq.
View article: Supplementary Figure S1-15 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Figure S1-15 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Figure S1-15
View article: Supplementary Methods S1 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Methods S1 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Methods S1. Patients and decitabine treatment, Sample size estimation, Collection of patient samples, Sample integration and unsupervised clustering and cell type annotation, Complexity tree-based annotation refinement, Inves…
View article: Supplementary Table S4 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Table S4 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Table S4. Clinical outcome of CK/MK AML or MDS treated with decitabine.
View article: Supplementary Data S1 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Data S1 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Data S1. Clinical data of decitabine trial.
View article: Supplementary Data S5 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Data S5 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Data S5. Differential gene and GSEA analysis of scRNA-seq.
View article: Supplementary Table S1 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Table S1 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Table S1. DNA sequencing of primers used in this study.
View article: Supplementary Table S2 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Table S2 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Table S2. List of materials used in this study.
View article: Data from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Data from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Purpose:Myelodysplastic syndrome and acute myeloid leukemia with complex and monosomy karyotypes show a high prevalence of TP53 mutations (TP53m), poor response to induction chemotherapy, and adverse outcomes. These diseases may respond to…
View article: Supplementary Data S4 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse
Supplementary Data S4 from Mechanism of Initial Favorable Response to Decitabine in <i>TP53</i>-Mutated MDS/AML and Potential Mechanisms of Subsequent Relapse Open
Supplementary Data S4. Trend analysis.
View article: Early measurable residual disease detection post-haematopoietic stem cell transplantation in acute myeloid leukaemia
Early measurable residual disease detection post-haematopoietic stem cell transplantation in acute myeloid leukaemia Open
Background: Detection of measurable residual disease (MRD) is becoming the standard of care in the prognostication of acute myeloid leukaemia post-chemotherapy, but its role in early post-haematopoietic stem cell transplantation (HSCT) is …
View article: Clinical spectrum of tuberculosis among HIV infected patients in India: Correlation with immunological status using CD4 counts
Clinical spectrum of tuberculosis among HIV infected patients in India: Correlation with immunological status using CD4 counts Open
Tuberculosis (TB) remains a common and serious opportunistic infection among HIV-infected individuals, with clinical presentation closely tied to immune status. In this prospective study of 100 HIV-positive patients with TB, pulmonary TB p…
View article: A multi-modal molecular characterization of the Philadelphia translocation featuring long read sequencing
A multi-modal molecular characterization of the Philadelphia translocation featuring long read sequencing Open
Using the Ph translocation as an example, long read sequencing is a promising alternative method to detect SV, revolutionizing detection of chromosomal translocation to a higher precision. A more comprehensive spectrum of SV can be resolve…
View article: Evaluating Antibiotic Prescribing Appropriateness in a Tertiary Care Hospital in Kerala Using Gyssens’ Categorization
Evaluating Antibiotic Prescribing Appropriateness in a Tertiary Care Hospital in Kerala Using Gyssens’ Categorization Open
The irrational use of antibiotics has contributed significantly to the global burden of antimicrobial resistance (AMR). This study evaluates antibiotic prescription patterns and rational drug use in a tertiary care hospital using WHO presc…
View article: Exploring the Therapeutic Potential of Nature Photography in Treating Anxiety and Depression amongst Students in FCT College of Education Abuja
Exploring the Therapeutic Potential of Nature Photography in Treating Anxiety and Depression amongst Students in FCT College of Education Abuja Open
This study explored the therapeutic potential of nature photography in treating anxiety and depression amongst students in FCT College of Education Zuba, FCT-Abuja. the study raised two research questions. The study employs a descriptive s…
View article: Mutation Spectrum Comparison between Benign Breast Lesion Cohort, Unselected Cancer Cohort and High-Risk Breast Cancer Cohort
Mutation Spectrum Comparison between Benign Breast Lesion Cohort, Unselected Cancer Cohort and High-Risk Breast Cancer Cohort Open
Mutation study for high-risk breast and ovarian cancer (HBOC) has been extensively studied in patients of different ethnicities. Here we compared the germline mutation rate and mutation spectrum of patients (n = 4341) with benign breast di…
View article: Germline RAD51C and RAD51D Mutations in High-Risk Chinese Breast and/or Ovarian Cancer Patients and Families
Germline RAD51C and RAD51D Mutations in High-Risk Chinese Breast and/or Ovarian Cancer Patients and Families Open
Background: RAD51C and RAD51D are crucial in homologous recombination (HR) DNA repair. The prevalence of the RAD51C and RAD51D mutations in breast cancer varies across ethnic groups. Associations of RAD51C and RAD51D germline pathogenic va…
View article: Double Heterozygosity for Germline Mutations in Chinese Breast Cancer Patients
Double Heterozygosity for Germline Mutations in Chinese Breast Cancer Patients Open
Double pathogenic mutations occurring in an individual are considered a rare event. The introduction of a multiple-gene panel at Hong Kong Hereditary Breast Cancer Family Registry has allowed the identification of pathogenic variants in mu…
View article: Comprehensive Review on Post Partum Depression
Comprehensive Review on Post Partum Depression Open
Postpartum depression (PPD) is a widespread and severely incapacitating mental illness that affects a large number of women globally. The complicated impacts of PPD on mothers and babies are the subject of this review paper, which focuses …