Eike Jakob Spruth
YOU?
Author Swipe
View article: SMAS: Structural MRI-based AD Score using Bayesian supervised VAE
SMAS: Structural MRI-based AD Score using Bayesian supervised VAE Open
This study introduces the Structural MRI-based Alzheimer's Disease Score (SMAS), a novel index intended to quantify Alzheimer's Disease (AD)-related morphometric patterns using a deep learning Bayesian-supervised Variational Autoencoder (B…
View article: Disease stage–specific atrophy markers in Alzheimer's disease
Disease stage–specific atrophy markers in Alzheimer's disease Open
INTRODUCTION Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrop…
View article: The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors
The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors Open
View article: Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance
Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance Open
Introduction We studied brain maintenance, examining the co-evolution of ageing-related atrophy, white matter hyperintensities (WMH), and cognition, alongside domain-specific and domain-general contributions of lifestyle and personality. M…
View article: <scp>Mini social cognition</scp> and <scp>emotional assessment</scp> : <scp>Diagnostic performance</scp> and <scp>neural correlates</scp> in behavioural‐variant <scp>frontotemporal dementia</scp>
<span>Mini social cognition</span> and <span>emotional assessment</span> : <span>Diagnostic performance</span> and <span>neural correlates</span> in behavioural‐variant <span>frontotemporal dementia</span> Open
We aimed at validating the Mini Social Cognition and Emotional Assessment (Mini‐SEA) in a German cohort of mildly impaired behavioural‐variant frontotemporal dementia (bvFTD) patients and healthy controls. The Mini‐SEA comprises the Facial…
View article: Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease
Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is characterised by the accumulation of beta-amyloid (Aβ) and tau proteins, leading to neurodegeneration and cognitive decline. While Aβ and tau are known to disrupt synaptic function, the mechanisms linking these …
View article: Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins
Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins Open
The challenge of early detection and stratification in Parkinson’s disease (PD) is urgent due to the current emergence of mechanism-based disease-modifying treatments. In here, metabolomic and lipidomic parameters obtained by a standardize…
View article: A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans Open
Background Convolutional neural network (CNN) based volumetry of MRI data can help differentiate Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD) as causes of cognitive decline and dementia. However, e…
View article: Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease Open
Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer’s disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limite…
View article: Linking higher amyloid beta 1‐38 (Aβ(1‐38)) levels to reduced Alzheimer's disease progression risk
Linking higher amyloid beta 1‐38 (Aβ(1‐38)) levels to reduced Alzheimer's disease progression risk Open
INTRODUCTION The beneficial effects of amyloid beta 1‐38, or Aβ(1‐38), on Alzheimer's disease (AD) progression in humans in vivo remain controversial. We investigated AD patients' cerebrospinal fluid (CSF) Aβ(1‐38) and AD progression. METH…
View article: CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum
CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum Open
Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning and attention and are known to be altered in neurodegenerative diseases like Alzheimer’s diseas…
View article: Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults
Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults Open
Background In humans, environmental enrichment (EE), as measured by the engagement in a variety of leisure activities, has been associated with larger hippocampal structure and better memory function. The present cross-sectional study asse…
View article: Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer’s disease
Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer’s disease Open
Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer’s disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coerul…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation
Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation Open
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively nor…
View article: Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease
Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease Open
View article: Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study Open
Background Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and the drivers of such a structural change in humans require longitudinal investigation. Elucidating the effects of demographic factors, hypertension, …
View article: Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults Open
Background For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis noneth…
View article: Dysfunction of the episodic memory network in the Alzheimer’s disease cascade
Dysfunction of the episodic memory network in the Alzheimer’s disease cascade Open
Alzheimer’s disease (AD) is a major cause of dementia and cognitive decline. Here we assessed how episodic memory circuit dysfunction, a hallmark of AD, is related to the longitudinal cascade of AD biomarkers, neurodegeneration and cogniti…
View article: GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)
GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA) Open
Background Multiple system atrophy (MSA), an atypical parkinsonian syndrome, is a rapidly progressive neurodegenerative disease with currently no established fluid biomarkers available. MSA is characterized by an oligodendroglial α-synucle…
View article: Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts
Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts Open
INTRODUCTION Subjective cognitive decline (SCD) in amyloid‐positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 in the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures…
View article: Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults Open
Background For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis remain…
View article: Symptomatic Clusters Related to Amyloid Positivity in Cognitively Unimpaired Individuals
Symptomatic Clusters Related to Amyloid Positivity in Cognitively Unimpaired Individuals Open
Background: The NIA-AA Research Framework on Alzheimer’s disease (AD) proposes a transitional stage (stage 2) characterized by subtle cognitive decline, subjective cognitive decline (SCD) and mild neurobehavioral symptoms (NPS). Objective:…
View article: Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS Open
View article: Single-value brain activity scores reflect both severity and risk across the Alzheimer’s continuum
Single-value brain activity scores reflect both severity and risk across the Alzheimer’s continuum Open
Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of h…
View article: Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks
Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks Open
Background Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity rema…
View article: Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study
Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study Open
Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless neede…
View article: Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology
Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology Open
INTRODUCTION Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer's disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain …
View article: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease
Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease Open
In this study, we aimed to understand the potential role of the gut microbiome in the development of Alzheimer's disease (AD). We took a multi-faceted approach to investigate this relationship. Urine metabolomics were examined in individua…