Ann E. Stapleton
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View article: Association of menopausal status and hormone use with bladder health and lower urinary tract symptoms in US women: results from the RISE FOR HEALTH study
Association of menopausal status and hormone use with bladder health and lower urinary tract symptoms in US women: results from the RISE FOR HEALTH study Open
Objectives: Most previous studies of genitourinary symptoms associated with menopause focus on comparisons of postmenopausal to premenopausal women and less is known about bladder health during menopause. We evaluated associations of menop…
View article: 155. Long-Acting Subcutaneous Lenacapavir in People with Multi-Drug Resistant HIV-1: 3-Year Results of the CAPELLA Study
155. Long-Acting Subcutaneous Lenacapavir in People with Multi-Drug Resistant HIV-1: 3-Year Results of the CAPELLA Study Open
Background Lenacapavir (LEN) is a highly potent, long-acting HIV-1 capsid inhibitor approved in combination with other antiretrovirals (ARVs), for the treatment of heavily treatment-experienced (HTE) people with HIV-1 (PWH) with multidrug …
View article: Shaping the Future of Infectious Diseases: The Journey to Promote Value, Opportunity, and Positive Messaging
Shaping the Future of Infectious Diseases: The Journey to Promote Value, Opportunity, and Positive Messaging Open
The field of infectious diseases (ID) offers a rewarding career path and is widely viewed as an essential subspecialty in medicine. However, in recent years, these positive aspects have been overshadowed by concerns surrounding low fellows…
View article: Association of Cardiac Troponin T With Coronary Atherosclerosis in Asymptomatic Primary Prevention People With HIV
Association of Cardiac Troponin T With Coronary Atherosclerosis in Asymptomatic Primary Prevention People With HIV Open
In PWH without known ASCVD, hs-cTnT levels were strongly associated with and improved prediction of subclinical coronary plaque. (Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults [REPRI…
View article: Feasibility of Home Collection for Urogenital Microbiome Samples
Feasibility of Home Collection for Urogenital Microbiome Samples Open
Importance Feasibility of home urogenital microbiome specimen collection is unknown. Objectives This study aimed to evaluate successful sample collection rates from home and clinical research centers. Study Design Adult women participants …
View article: Exploring women's bladder self‐care practices: A qualitative secondary analysis
Exploring women's bladder self‐care practices: A qualitative secondary analysis Open
Aims To describe women's experiences with a range of bladder self‐care practices. Design We conducted a secondary, directed content analysis of qualitative data from the Study of Habits, Attitudes, Realities and Experiences, a multisite fo…
View article: Microbial Threshold Guidelines for UTI Diagnosis: A Scoping Systematic Review
Microbial Threshold Guidelines for UTI Diagnosis: A Scoping Systematic Review Open
Given the growing impact of antimicrobial resistance, improvements in diagnosis and treatment of the most common outpatient infection, urinary tract infection (UTI), are of great interest to stakeholders. Regulatory authorities have long a…
View article: Need for Public Health Messaging Related to Bladder Health from Adolescence to Advanced Age
Need for Public Health Messaging Related to Bladder Health from Adolescence to Advanced Age Open
Objective: The purpose of this analysis was to explore adolescent and adult women's interest in public health messaging around bladder health and perceptions of its usefulness. Materials and Methods: Directed content analysis of focus grou…
View article: Erratum for Stapleton et al., “Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review”
Erratum for Stapleton et al., “Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review” Open
Volume 64, no. 10, e00862-20, 2021, https://doi.org/10.1128/AAC.00862-20. The numbering of references 38 to 73 in the References list was incorrect as originally published and has been corrected, and several in-text citations were also cor…
View article: 1696. The Black Box of Using Health Claims-Based Analyses to Estimate UTI Prevalence in Community-Dwelling Women
1696. The Black Box of Using Health Claims-Based Analyses to Estimate UTI Prevalence in Community-Dwelling Women Open
Background Urinary tract infections (UTIs) are common in women but most epidemiology studies occurred in specialized settings (university health clinics) or used outdated methods (random digit dialing). Currently, women receive UTI care in…
View article: Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review
Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review Open
Antibiotic resistance is a threat to public health, and uncomplicated urinary tract infections (uUTIs) are an example of this concern. This systematic review (International Prospective Register of Systematic Reviews [PROSPERO] ID: CRD42020…
View article: Revisiting the Spectrum of Bladder Health: Relationships Between Lower Urinary Tract Symptoms and Multiple Measures of Well-Being
Revisiting the Spectrum of Bladder Health: Relationships Between Lower Urinary Tract Symptoms and Multiple Measures of Well-Being Open
Background: Little research to date has investigated the spectrum of bladder health in women, including both bladder function and well-being. Therefore, we expanded our previous baseline analysis of bladder health in the Boston Area Commun…
View article: Converging on Bladder Health through Design Thinking: From an Ecology of Influence to a Focused Set of Research Questions
Converging on Bladder Health through Design Thinking: From an Ecology of Influence to a Focused Set of Research Questions Open
Lower urinary tract symptoms affect a substantial number of women in the United States (U.S.) and globally. In 2015, the Prevention of Lower Urinary tract Symptoms in women (PLUS) Research Consortium was funded to establish the scientific …
View article: A Bayesian multivariate meta‐analysis of prevalence data
A Bayesian multivariate meta‐analysis of prevalence data Open
When conducting a meta‐analysis involving prevalence data for an outcome with several subtypes, each of them is typically analyzed separately using a univariate meta‐analysis model. Recently, multivariate meta‐analysis models have been sho…
View article: Asymptomatic Bacteriuria and Pyuria in Premenopausal Women
Asymptomatic Bacteriuria and Pyuria in Premenopausal Women Open
Background Asymptomatic bacteriuria and pyuria in healthy women often trigger inappropriate antimicrobial treatment, but there is a paucity of data on their prevalence and persistence. Methods To evaluate the prevalence and persistence of …
View article: Applying concepts of life course theory and life course epidemiology to the study of bladder health and lower urinary tract symptoms among girls and women
Applying concepts of life course theory and life course epidemiology to the study of bladder health and lower urinary tract symptoms among girls and women Open
Aims Although lower urinary tract symptoms (LUTS) may occur at different periods during the life course of women, a little research on LUTS has adopted a life course perspective. The purpose of this conceptual paper is to demonstrate how l…
View article: Normative noninvasive bladder function measurements in healthy women: A systematic review and meta‐analysis
Normative noninvasive bladder function measurements in healthy women: A systematic review and meta‐analysis Open
Aim To conduct an evidence synthesis of normative reference values for bladder function parameters in women. Methods We conducted a systematic review and meta‐analysis of studies reporting bladder function parameters obtained from noninvas…
View article: Development of Conceptual Models to Guide Public Health Research, Practice, and Policy: Synthesizing Traditional and Contemporary Paradigms
Development of Conceptual Models to Guide Public Health Research, Practice, and Policy: Synthesizing Traditional and Contemporary Paradigms Open
This applied paper is intended to serve as a “how to” guide for public health researchers, practitioners, and policy makers who are interested in building conceptual models to convey their ideas to diverse audiences. Conceptual models can …
View article: 1484. Prevalence of Pyuria With and Without Bacteriuria in Healthy Pre-Menopausal Women
1484. Prevalence of Pyuria With and Without Bacteriuria in Healthy Pre-Menopausal Women Open
Background Pyuria has long been considered key to diagnosis of urinary tract infection in women, but there is a paucity of data on its prevalence and association with asymptomatic bacteriuria (ASB) in healthy women, even though pyuria and …
View article: The Emperor’s New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE)
The Emperor’s New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE) Open
Background Vancomycin is the most commonly administered antibiotic in hospitalized patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure range, this study evaluated the association between vancomy…
View article: The Spectrum of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms and Interference with Activities
The Spectrum of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms and Interference with Activities Open
Background: Little research to date has focused on lower urinary tract symptom (LUTS) prevention and bladder health promotion in women. To address this gap, the Prevention of LUTS Research Consortium developed the following working bladder…
View article: Terminology for bladder health research in women and girls: Prevention of Lower Urinary Tract Symptoms transdisciplinary consortium definitions
Terminology for bladder health research in women and girls: Prevention of Lower Urinary Tract Symptoms transdisciplinary consortium definitions Open
Aim To report research terminology and definitions for describing healthy bladder function among women and girls. Methods The Prevention of Lower Urinary tract Symptoms (PLUS) Consortium developed research terminology and definitions for e…