Martin Stocker
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View article: Association between nitric oxide treatment and intraventricular hemorrhage among extremely preterm neonates in Switzerland, 2012–2020
Association between nitric oxide treatment and intraventricular hemorrhage among extremely preterm neonates in Switzerland, 2012–2020 Open
Inhaled nitric oxide (iNO) treatment is routinely used to treat newborns suffering from severe respiratory distress syndrome (RDS). While the treatment is established for term born infants, its safety and efficacy remain controversial amon…
View article: Rare variants in infection response protein pathways associated with sepsis in children
Rare variants in infection response protein pathways associated with sepsis in children Open
1 Abstract Sepsis is a major contributor to mortality in paediatric patients. We investigated the human genetic underpinnings of sepsis by analysing a large paediatric cohort with blood-culture confirmed sepsis through multi-tiered genomic…
NapBiome trial: Targeting gut microbiota to improve sleep rhythm and developmental and behavioural outcomes in early childhood in a birth cohort in Switzerland – a study protocol Open
Introduction The gut–brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels importan…
A systematic review of Perinatal Antibiotic Stewardship – where we are, where to go? Open
The perinatal period is associated with high antibiotic exposure, which raises concerns about antimicrobial resistance (AMR) and future health impacts. The aim of this comprehensive systematic review, including publications from 2000 to 20…
View article: Paediatric Personalized Research Network Switzerland (SwissPedHealth): a joint paediatric national data stream
Paediatric Personalized Research Network Switzerland (SwissPedHealth): a joint paediatric national data stream Open
Introduction Children represent a large and vulnerable patient group. However, the evidence base for most paediatric diagnostic and therapeutic procedures remains limited or is often inferred from adults. There is an urgency to improve pae…
Antibiotic exposure for culture-negative early-onset sepsis in late-preterm and term newborns: an international study Open
Background Early-life antibiotic exposure is disproportionately high compared to the burden of culture-proven early-onset sepsis (CP-EOS). We assessed the contribution of culture-negative cases to the overall antibiotic exposure in the fir…
View article: Paediatric Personalized Research Network Switzerland (SwissPedHealth): A Joint Paediatric National Data Stream
Paediatric Personalized Research Network Switzerland (SwissPedHealth): A Joint Paediatric National Data Stream Open
Introduction Children represent a large and vulnerable patient group. However, the evidence-base for most paediatric diagnostic and therapeutic procedures remains limited or is often inferred from adults. There is urgency to improve paedia…
View article: Organ Dysfunction in Children With Blood Culture-Proven Sepsis: Comparative Performance of Four Scores in a National Cohort Study
Organ Dysfunction in Children With Blood Culture-Proven Sepsis: Comparative Performance of Four Scores in a National Cohort Study Open
OBJECTIVES: Previous studies applying Sepsis-3 criteria to children were based on retrospective analyses of PICU cohorts. We aimed to compare organ dysfunction criteria in children with blood culture-proven sepsis, including emergency depa…
View article: Cerebral Oximetry Monitoring in Extremely Preterm Infants
Cerebral Oximetry Monitoring in Extremely Preterm Infants Open
In extremely preterm infants, treatment guided by cerebral oximetry monitoring for the first 72 hours after birth was not associated with a lower incidence of death or severe brain injury at 36 weeks' postmenstrual age than usual care. (Fu…
View article: Swiss Sepsis National Action Plan: A coordinated national action plan to stop sepsis-related preventable deaths and to improve the support of people affected by sepsis in Switzerland
Swiss Sepsis National Action Plan: A coordinated national action plan to stop sepsis-related preventable deaths and to improve the support of people affected by sepsis in Switzerland Open
Background Sepsis is a devastating disease which causes yearly over 10 million deaths worldwide. In 2017, the World Health Organization (WHO) issued a resolution prompting member states to improve the prevention, recognition, and managemen…
View article: Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia
Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia Open
Importance Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying e…
Impact of SARS-CoV-2 on incidence, treatment and outcome of very preterm born infants in Switzerland: a retrospective, population-based cohort study Open
AIMS OF THE STUDY: To assess whether the COVID-19 pandemic caused by SARS-CoV-2 had an impact on incidence, treatment or major adverse short-term outcome of preterm-born infants in Switzerland. METHODS: Retrospective cohort study of preter…
Prediction of recovery from multiple organ dysfunction syndrome in pediatric sepsis patients Open
Motivation Sepsis is a leading cause of death and disability in children globally, accounting for ∼3 million childhood deaths per year. In pediatric sepsis patients, the multiple organ dysfunction syndrome (MODS) is considered a significan…
A qualitative analysis of critical incident reporting in a paediatric hospital: benefits and weaknesses Open
AIMS OF THE STUDY: The value of critical incident reporting systems (CIRSs) has been shown before but data for paediatric facilities are scarce. We aimed to evaluate a CIRS in a paediatric hospital to analyse its benefits, weaknesses and o…
View article: Newborns with Bloody Stools—At the Crossroad between Efficient Management of Necrotizing Enterocolitis and Antibiotic Stewardship
Newborns with Bloody Stools—At the Crossroad between Efficient Management of Necrotizing Enterocolitis and Antibiotic Stewardship Open
The onset of bloody stools in neonates often results in antibiotic treatment for suspected necrotizing enterocolitis (NEC). Food protein-induced allergic proctocolitis (FPIAP) is an often-neglected differential diagnosis. We performed a re…
View article: Newborns with Bloody Stools—At the Crossroad between Efficient Management of Necrotizing Enterocolitis and Antibiotic Stewardship
Newborns with Bloody Stools—At the Crossroad between Efficient Management of Necrotizing Enterocolitis and Antibiotic Stewardship Open
The onset of bloody stools in neonates often results in antibiotic treatment for suspected necrotizing enterocolitis (NEC). Food protein-induced allergic proctocolitis (FPIAP) is an often-neglected differential diagnosis. We performed a re…