E. Susan Slechta
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View article: Genomic Analysis of Global <i>Mycobacterium abscessus</i> Isolates Reveals Ongoing Evolution of Drug Resistance–Associated Genes
Genomic Analysis of Global <i>Mycobacterium abscessus</i> Isolates Reveals Ongoing Evolution of Drug Resistance–Associated Genes Open
Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5617 clinical MAB isolates from 20 countries and searched fo…
View article: Evaluation of the LifeScale system for rapid phenotypic antimicrobial susceptibility testing from positive blood cultures
Evaluation of the LifeScale system for rapid phenotypic antimicrobial susceptibility testing from positive blood cultures Open
Objective The spread of antimicrobial resistance is a growing threat to public health, thus there is a critical need for prompt and reliable antimicrobial susceptibility testing (AST). Rapid AST may improve patient outcomes by allowing for…
View article: Rapid and Accurate Differentiation of Mycobacteroides abscessus Complex Species by Liquid Chromatography-Ultra-High-Resolution Orbitrap™ Mass Spectrometry
Rapid and Accurate Differentiation of Mycobacteroides abscessus Complex Species by Liquid Chromatography-Ultra-High-Resolution Orbitrap™ Mass Spectrometry Open
In this study, a Liquid Chromatography-Mass Spectrometry (LC-MS) method for the identification of clinically relevant Mycobacteroides abscessus ( Mabs ) complex organisms is tested using a set of microbial Type strains. This methodology is…
View article: Clinical Laboratory Perspective on <i>Streptococcus halichoeri</i>, an Unusual Nonhemolytic, Lancefield Group B Streptococcus Causing Human Infections
Clinical Laboratory Perspective on <i>Streptococcus halichoeri</i>, an Unusual Nonhemolytic, Lancefield Group B Streptococcus Causing Human Infections Open
Streptococcus halichoeri is a relatively newly identified species of pyogenic streptococci that causes zoonotic infection in humans. S. halichoeri was first described in 2004 as indigenous to seals, and only 8 reports of human S. halichoer…
View article: Clinical Laboratory Perspective on <i>Streptococcus halichoeri</i>, an Unusual Nonhemolytic, Lancefield Group B Streptococcus Causing Human Infections
Clinical Laboratory Perspective on <i>Streptococcus halichoeri</i>, an Unusual Nonhemolytic, Lancefield Group B Streptococcus Causing Human Infections Open
Streptococcus halichoeri is a relatively newly identified species of pyogenic streptococci that causes zoonotic infection in humans. S. halichoeri was first described in 2004 as indigenous to seals, and only 8 reports of human S. halichoer…
View article: Multicenter Study Demonstrates Standardization Requirements for Mold Identification by MALDI-TOF MS
Multicenter Study Demonstrates Standardization Requirements for Mold Identification by MALDI-TOF MS Open
Successful mold identification using the NIH Database for MALDI-TOF MS on Biotyper systems was demonstrated across multiple institutions for the first time following identification of critical program parameters combined with instrument op…
View article: Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers
Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers Open
We evaluated the effects of rifampin coadministration and MDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in the clearance (0.53 versus 0.55 li…
View article: Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species
Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species Open
This multicenter study was designed to assess the accuracy and reproducibility of the Vitek MS v3.0 matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry system for identification of Mycobacterium and Noc…
View article: Helicobacter canis bacteraemia and cellulitis in a patient with end-stage renal disease
Helicobacter canis bacteraemia and cellulitis in a patient with end-stage renal disease Open
Introduction. Invasive infections by Helicobacter canis are uncommon and occur primarily in immunocompromised patients. Here, we describe a case of H. canis bacteraemia and cellulitis in a patient with end-stage renal disease (ESRD). Case …