Erik Thorlund Parner
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View article: Long-term prognostic impact of complete revascularisation defined by CT-derived fractional flow reserve
Long-term prognostic impact of complete revascularisation defined by CT-derived fractional flow reserve Open
Background Complete revascularisation has been associated with improved short-term outcomes in patients with coronary artery disease, but whether these benefits persist long-term and can be defined non-invasively remains uncertain. We inve…
View article: Long-term lymphedema and quality of life following lymph node staging in early cervical cancer: 3-year follow-up in the prospective multicenter SENTIREC CERVIX study
Long-term lymphedema and quality of life following lymph node staging in early cervical cancer: 3-year follow-up in the prospective multicenter SENTIREC CERVIX study Open
Patients with cervical cancer reported long-term leg lymphedema, most pronounced after sentinel lymph node mapping with pelvic lymphadenectomy, and to a lesser extent after sentinel lymph node mapping alone. Three-month leg lymphedema scor…
View article: How much running is too much? Identifying high-risk running sessions in a 5200-person cohort study
How much running is too much? Identifying high-risk running sessions in a 5200-person cohort study Open
Objectives We explored whether a spike in running distance during a single session or over 1 week, compared with the preceding period, was associated with increased risk of running-related overuse injury. Methods Adult runners were recruit…
View article: P-241 Evaluating clinical utility of embryo selection algorithms: reducing time to live birth through deep learning and multiple imputation
P-241 Evaluating clinical utility of embryo selection algorithms: reducing time to live birth through deep learning and multiple imputation Open
Study question To evaluate the clinical utility of embryo selection algorithms by estimating the time to live birth (TTLB). Summary answer Using multiple imputations, the clinical utility of embryo selection algorithms was estimated, showi…
View article: Limits of Agreement Based on Transformed Measurements
Limits of Agreement Based on Transformed Measurements Open
Method comparison studies are typically analyzed using limits of agreement (LoAs). The standard Bland–Altman approach estimates LoAs under the assumption that the differences between methods follow a normal distribution. However, many type…
View article: Role of intra‐individual variation in the detection of thresholds for DFI and for misclassification rates: A retrospective analysis of 14,775 SCSA<sup>®</sup> tests
Role of intra‐individual variation in the detection of thresholds for DFI and for misclassification rates: A retrospective analysis of 14,775 SCSA<sup>®</sup> tests Open
Background Sperm DNA damage is associated with reduced male fertility after natural conception and intrauterine insemination. However, the impact on in vitro fertilization (IVF) and especially intracytoplasmic sperm injection (ICSI) treatm…
View article: Familial risk of sinus node dysfunction indicating pacemaker implantation: a nationwide cohort study
Familial risk of sinus node dysfunction indicating pacemaker implantation: a nationwide cohort study Open
Aims We aimed to investigate the risk of sinus node dysfunction (SND) indicating cardiac pacing and mortality in first-degree relatives to patients with a pacemaker implanted on this indication and assess the effect of onset-age on disease…
View article: Coronary CT angiography instead of invasive angiography before TAVI: Feasibility and outcomes
Coronary CT angiography instead of invasive angiography before TAVI: Feasibility and outcomes Open
Upfront cCTA instead of ICA for assessment of obstructive CAD in the diagnostic workup of patients with severe aortic stenosis referred to TAVI is feasible, safe, and with similar procedural and clinical outcomes. Randomized studies are wa…
View article: Interscan reproducibility of computed tomography derived coronary plaque volume measurements
Interscan reproducibility of computed tomography derived coronary plaque volume measurements Open
Overall reproducibility of repeated CCTA derived plaque measurements by a semi-automated software was modest, and was influenced by image quality, image reconstruction settings, and lesion location.
View article: 3‐generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open‐source catalog of findings
3‐generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open‐source catalog of findings Open
The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism e…
View article: Estimation of win, loss probabilities, and win ratio based on right‐censored event data
Estimation of win, loss probabilities, and win ratio based on right‐censored event data Open
The win ratio has in the recent decade gained popularity for analyzing prioritized multiple event data in clinical cohort studies, in particular within cardiovascular research. The literature on estimation of the win ratio using censored e…
View article: Familial aggregation of sinus node dysfunction indicating pacemaker implantation: A nation-wide cohort study
Familial aggregation of sinus node dysfunction indicating pacemaker implantation: A nation-wide cohort study Open
Background Rare genetically inherited forms of sinus node dysfunction (SND) have been described but the significance of a family history of SND and the associated prognosis remains unknown. Purpose To investigate the risk of SND indicating…
View article: Coronary computed tomography angiography derived fractional flow reserve and risk of recurrent angina: A 3-year follow-up study
Coronary computed tomography angiography derived fractional flow reserve and risk of recurrent angina: A 3-year follow-up study Open
In patients with SAP and coronary stenosis by CTA undergoing standard-of-care guided treatment, FFRCT provides information regarding risk of recurrent angina.
View article: 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: an open-source catalogue of findings
3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: an open-source catalogue of findings Open
The relatively few conditions and family members investigated in autism family health history limits etiologic understanding. For more comprehensive understanding and hypothesis-generation we produced an open- source catalogue of autism as…
View article: SO010/#1243 Risks and benefits of a national adoption of sentinel node mapping in low and intermediate risk endometrial cancer -the sentirec-endo study
SO010/#1243 Risks and benefits of a national adoption of sentinel node mapping in low and intermediate risk endometrial cancer -the sentirec-endo study Open
Introduction Surgical staging of endometrial cancer (EC) serves to allocate women with lymph node metastases to adjuvant treatment. Sentinel lymph node (SLN) mapping can accurately detect lymph node metastases in women with EC of low- or i…
View article: SO015LBA/#1261 Identifying a safe algorithm for sentinel lymph node mapping in high-risk endometrial cancer; the sentirec endo study
SO015LBA/#1261 Identifying a safe algorithm for sentinel lymph node mapping in high-risk endometrial cancer; the sentirec endo study Open
Introduction Sentinel lymph node (SLN) mapping is suggested to be a safe staging method for women with high-risk endometrial cancer (EC). However, approximately 20–45% of women have failed mapping, leaving a need for consensus on the choic…
View article: Win‐loss parameters for right‐censored event data, with application to recurrent events
Win‐loss parameters for right‐censored event data, with application to recurrent events Open
The win ratio has become a popular method for comparing multiple event data between two groups in clinical cohort studies. The win ratio compares the event data in prioritized order, where the first prioritized event is death and a typical…
View article: Prognostic Value of Coronary CT Angiography–derived Fractional Flow Reserve on 3-year Outcomes in Patients with Stable Angina
Prognostic Value of Coronary CT Angiography–derived Fractional Flow Reserve on 3-year Outcomes in Patients with Stable Angina Open
Background The prognostic value of coronary CT angiography (CTA)-derived fractional flow reserve (FFR) beyond 1-year outcomes and in patients with high levels of coronary artery calcium (CAC) is uncertain. Purpose To assess the prognostic …
View article: #221 The SENTIREC-endo study – risks and benefits of a national adoption of sentinel node mapping in low and intermediate risk endometrial cancer
#221 The SENTIREC-endo study – risks and benefits of a national adoption of sentinel node mapping in low and intermediate risk endometrial cancer Open
Introduction/Background Surgical staging of endometrial cancer (EC) serves to allocate women with lymph node metastases to adjuvant treatment. Sentinel lymph node (SLN) mapping has shown high accuracy to detect lymph node metastases in wom…
View article: #379 A safe algorithm for sentinel lymph node mapping in high-risk endometrial cancer; the SENTIREC endo study
#379 A safe algorithm for sentinel lymph node mapping in high-risk endometrial cancer; the SENTIREC endo study Open
Introduction/Background Sentinel lymph node (SLN) mapping is suggested to be a safe surgical staging method for women with high-risk (grade 3 or non-endometrioid histology) endometrial cancer (EC). However, approximately 20% of women do no…
View article: Pseudo-observations in a multistate setting
Pseudo-observations in a multistate setting Open
Regression analyses of how state occupation probabilities or expected lengths of stay depend on covariates in multistate settings can be performed using the pseudo-observation method, which involves calculating jackknife pseudo-observation…
View article: Regression models for censored time-to-event data using infinitesimal jack-knife pseudo-observations, with applications to left-truncation
Regression models for censored time-to-event data using infinitesimal jack-knife pseudo-observations, with applications to left-truncation Open
Jack-knife pseudo-observations have in recent decades gained popularity in regression analysis for various aspects of time-to-event data. A limitation of the jack-knife pseudo-observations is that their computation is time consuming, as th…
View article: Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?
Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role? Open
Background Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists in two structural…
View article: Completeness of revascularization by FFRCT and prognosis in stable chest pain
Completeness of revascularization by FFRCT and prognosis in stable chest pain Open
Introduction Major randomized trials of patients with stable chest pain (CP) demonstrated no prognostic benefits of coronary revascularization over optimal medical treatment (OMT). However, in a recent large-scale study, completeness of re…
View article: FFRCT and recurrent symptoms in patients with stable chest pain
FFRCT and recurrent symptoms in patients with stable chest pain Open
Introduction The major benefit of coronary revascularization when compared with optimal medical treatment (OMT) in patients with stable chest pain (CP) relates to improvement of symptoms and reduction of reinterventions. Non-invasive metho…