E. Van Assche
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View article: Epilepsy and mental health disorders: current challenges and potential solutions
Epilepsy and mental health disorders: current challenges and potential solutions Open
Summary Epilepsy affects ~50 million people worldwide and is associated with increased psychiatric comorbidities, including depression, anxiety, psychosis and suicidality. Despite this, current epilepsy management primarily focusses on sei…
View article: 651. DISCOVERY OF OMICS-BIOMARKERS OF KETAMINE FOR TREATMENT RESPONSE IN DEPRESSION
651. DISCOVERY OF OMICS-BIOMARKERS OF KETAMINE FOR TREATMENT RESPONSE IN DEPRESSION Open
Background DNA methylation is a biomarker suited to investigate dynamic processes, such as treatment response. For this analysis we focus on DNA methylation changes during a randomised controlled trial (RCT) in treatment resistant depresse…
View article: DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial
DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial Open
DNA methylation is a dynamic biomarker suited to investigate processes, e.g., treatment response. We investigate DNA methylation changes in different dosing paradigms for ketamine (s.c.) vs. midazolam (s.c.) in treatment resistant depresse…
View article: The ‘time’ in lifetime: age-stratification and its impact on immune-based depression treatment
The ‘time’ in lifetime: age-stratification and its impact on immune-based depression treatment Open
Introduction Depression is increasingly linked to immunological processes. Therefore, immune-based therapies, e.g., celecoxib, are being tested as augmenting treatment strategies. Many physiological processes during life are also linked to…
View article: Neurobiological characteristics of treatment resistance and predictors of treatment tolerability for schizophrenia
Neurobiological characteristics of treatment resistance and predictors of treatment tolerability for schizophrenia Open
Schizophrenia is a chronic disorder with a massive impact on quality of life. The prevalence of treatment resistance has been estimated around 30%. Treatment resistance is typically defined as non-response to 2 antipsychotics of adequate d…
View article: Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review
Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review Open
Major depressive disorder (MDD) shows a large heterogeneity in antidepressant treatment outcome, a variability explained in part by common-variant liability captured by polygenic scores (PGSs). We performed a review of PubMed- and Google S…
View article: Exploring the use of immunomethylomics in the characterization of depressed patients: A proof-of-concept study
Exploring the use of immunomethylomics in the characterization of depressed patients: A proof-of-concept study Open
Alterations in DNA methylation and inflammation could represent valid biomarkers for the stratification of patients with major depressive disorder (MDD). This study explored the use of DNA-methylation based immunological cell-type profiles…
View article: Long-Term Immunomodulatory Impact of VNS on Peripheral Cytokine Profiles and Its Relationship with Clinical Response in Difficult-to-Treat Depression (DTD)
Long-Term Immunomodulatory Impact of VNS on Peripheral Cytokine Profiles and Its Relationship with Clinical Response in Difficult-to-Treat Depression (DTD) Open
Vagus nerve stimulation (VNS) represents a long-term adjunctive treatment option in patients with difficult-to-treat depression (DTD). Anti-inflammatory effects have been discussed as a key mechanism of action of VNS. However, long-term in…
View article: DNA methylation risk scores for depression, not today
DNA methylation risk scores for depression, not today Open
Introduction After the success of polygenic risk scores (PRS) that embed a useful summary of genomic information in a comprehensive score, the wish to develop summary statistics for DNA methylation had become more pressing. Developing such…
View article: DNA methylation signatures support the role of neutrophils and monocytes in depression
DNA methylation signatures support the role of neutrophils and monocytes in depression Open
Introduction Research repeatedly linked inflammation with major depressive disorder (MDD). The presence of an inflammatory subtype of depression is supported by molecular findings as well as imaging reports. We investigated the cell type c…
View article: Longitudinal early epigenomic signatures inform molecular paths of therapy response and remission in depressed patients
Longitudinal early epigenomic signatures inform molecular paths of therapy response and remission in depressed patients Open
Introduction The etiology of major depressive disorder (MDD) involves the interaction between genes and environment, including treatment. Early molecular signatures for treatment response and remission are relevant in a context of personal…
View article: Editorial: Cross-disorder Genetics in Neuropsychiatry
Editorial: Cross-disorder Genetics in Neuropsychiatry Open
EDITORIAL article Front. Neurosci., 09 February 2022 | https://doi.org/10.3389/fnins.2022.826300
View article: Genetic Susceptibility to Clozapine-Induced Agranulocytosis/Neutropenia Across Ethnicities: Results From a New Cohort of Turkish and Other Caucasian Participants, and Meta-Analysis
Genetic Susceptibility to Clozapine-Induced Agranulocytosis/Neutropenia Across Ethnicities: Results From a New Cohort of Turkish and Other Caucasian Participants, and Meta-Analysis Open
Clozapine (CLZ) is considered the most effective antipsychotic, but its use is associated with neutropenia (CIN) and agranulocytosis (CIA). Although the exact etiology of these hazardous side effects is unknown, 4 genetic polymorphisms hav…
View article: Gene–environment interaction: New insights into perceived parenting and social anxiety among adolescents
Gene–environment interaction: New insights into perceived parenting and social anxiety among adolescents Open
Background. Social anxiety symptoms (SAS) are among the most common mental health problems during adolescence, and it has been shown that parenting influences the adolescent’s level of social anxiety. In addition, it is now widely assumed …
View article: A <scp>SNP</scp>, Gene, and Polygenic Risk Score Approach of Oxytocin‐Vasopressin Genes in Adolescents’ Loneliness
A <span>SNP</span>, Gene, and Polygenic Risk Score Approach of Oxytocin‐Vasopressin Genes in Adolescents’ Loneliness Open
Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline …
View article: Gene‐based interaction analysis shows <scp>GABA</scp> ergic genes interacting with parenting in adolescent depressive symptoms
Gene‐based interaction analysis shows <span>GABA</span> ergic genes interacting with parenting in adolescent depressive symptoms Open
Background Most gene‐environment interaction studies (G × E) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that ac…
View article: Effect of seortonin transporter gene and parental support interaction on adolescents' loneliness: A replication study
Effect of seortonin transporter gene and parental support interaction on adolescents' loneliness: A replication study Open
E ects for parental support and gender were replicated. These e ects seem more robust. Study aim We replicated the van Roekel et al. (2010) study on the interaction of 5-HTTLPR and parental support on adolescent’s loneliness. The replicabi…