Erkki Vartiainen
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View article: Shotgun metagenomics reveals distinct skin microbial species in allergen-sensitized individuals
Shotgun metagenomics reveals distinct skin microbial species in allergen-sensitized individuals Open
The Karelian region, which spans the border between Finland and Russia, presents distinct environmental exposures and lifestyles on either side of the governmental border. In the more urbanized Finnish Karelia, allergic diseases are marked…
View article: Serum metabolites link immune-microbiota interaction in children and young adults from Russian Karelia and Finnish Karelia with contrasting lifestyle and environment
Serum metabolites link immune-microbiota interaction in children and young adults from Russian Karelia and Finnish Karelia with contrasting lifestyle and environment Open
Multi-omics integration revealed a more coordinated and responsive immune-metabolic network in RUS youth, potentially shaped by environmental exposures typical of their living context. In contrast, the FIN cohort exhibited metabolic patter…
View article: FINRISK 3.0: A new formula for cardiovascular risk prediction with LDL and 30-year risk projections
FINRISK 3.0: A new formula for cardiovascular risk prediction with LDL and 30-year risk projections Open
Background The FINRISK calculator has been in use in Finland since 2007 to predict 10-year risk of acute coronary heart disease (CHD), stroke, or either of them (i.e. cardiovascular disease, CVD). This study describes the development of th…
View article: Body Mass Index and the Risk of Adult-Onset Asthma: A Prospective Observational Study among 59,668 Middle-Aged Men and Women in Finland
Body Mass Index and the Risk of Adult-Onset Asthma: A Prospective Observational Study among 59,668 Middle-Aged Men and Women in Finland Open
Introduction: Obesity, in addition to many other negative health consequences, affects pulmonary function and is a potential risk factor for asthma. Methods: We analyzed the association of body mass index (BMI) with incident asthma among 6…
View article: The North Karelia lessons for prevention of cardiovascular disease
The North Karelia lessons for prevention of cardiovascular disease Open
Background: As a result of the high cardiovascular disease (CVD) rates in Finland in late 1960’s, which became a source of national concern, a major community based programme for CVD prevention called the North Karelia project was establis…
View article: A short history from Karelia study to biodiversity and public health interventions
A short history from Karelia study to biodiversity and public health interventions Open
Contact with natural environments enriches the human microbiome, promotes immune balance and protects against allergies and inflammatory disorders. In Finland, the allergy & asthma epidemic became slowly visible in mid 1960s. After the…
View article: Achieving health through diet: a joint event of the Sabri Ülker Foundation and The Nutrition Society of UK and Ireland, May 2022
Achieving health through diet: a joint event of the Sabri Ülker Foundation and The Nutrition Society of UK and Ireland, May 2022 Open
Optimum nutrition plays a major role in the achievement and maintenance of good health. The Nutrition Society of the UK and Ireland and the Sabri Ülker Foundation, a charity based in Türkiye and focused on improving public health, combined…
View article: Risk prediction of atrial fibrillation and its complications in the community using hs troponin I
Risk prediction of atrial fibrillation and its complications in the community using hs troponin I Open
Aims Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood‐based biomarkers reflecting cardiac injury such as high‐sensitivity troponin I (hsTnI) may hel…
View article: Exploring the incremental utility of circulating biomarkers for robust risk prediction of incident atrial fibrillation in European cohorts using regressions and modern machine learning methods
Exploring the incremental utility of circulating biomarkers for robust risk prediction of incident atrial fibrillation in European cohorts using regressions and modern machine learning methods Open
Aims To identify robust circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning (ML) techniques within a broad spectrum of candidate variables. Methods and results In pooled European co…
View article: Contribution of smoking change to 45-year trend in prevalence of chronic bronchitis in Finland
Contribution of smoking change to 45-year trend in prevalence of chronic bronchitis in Finland Open
Aims: Tobacco smoking has been identified as the most important risk factor of chronic bronchitis. The aim of this study was to assess the contribution of smoking to the trends in prevalence of chronic bronchitis among men and women in Fin…
View article: Effectiveness of a 3-year community-based intervention for blood pressure reduction among adults: a repeated cross-sectional study with a comparison area
Effectiveness of a 3-year community-based intervention for blood pressure reduction among adults: a repeated cross-sectional study with a comparison area Open
Raised blood pressure is the leading risk factor for cardiovascular diseases. We aimed to demonstrate the effectiveness of a 3-year community-based healthy lifestyle promotion intervention at a neighbourhood level for blood pressure reduct…
View article: Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals
Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals Open
Objective: Previous studies on the association between metabolic biomarkers and hypertension have been limited by small sample sizes, low number of studied biomarkers, and cross-sectional study design. In the largest study to date, we asse…
View article: Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes Open
AIMS
There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the s…
View article: Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes Open
Aims There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spe…
View article: Immune‐microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence
Immune‐microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence Open
Background After the Second World War, the population living in the Karelian region was strictly divided by the “iron curtain” between Finland and Russia. This resulted in different lifestyle, standard of living, and exposure to the enviro…
View article: Cardiac Troponin I and Incident Stroke in European Cohorts
Cardiac Troponin I and Incident Stroke in European Cohorts Open
Background and Purpose: Stroke is a common cause of death and a leading cause of disability and morbidity. Stroke risk assessment remains a challenge, but circulating biomarkers may improve risk prediction. Controversial evidence is availa…
View article: Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals
Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals Open
Background Several small‐scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable‐adjusted assoc…
View article: Measurement error as an explanation for the alcohol harm paradox: analysis of eight cohort studies
Measurement error as an explanation for the alcohol harm paradox: analysis of eight cohort studies Open
Background Despite reporting lower levels of alcohol consumption, people with lower socio-economic status (SES) experience greater alcohol-related harm. Whether differential biases in the measurement of alcohol use could explain this appar…
View article: Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death
Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death Open
Background Differences in risk factors for atrial fibrillation (AF) and heart failure (HF) are incompletely understood. Aim of this study was to understand whether risk factors and biomarkers show different associations with incident AF an…
View article: Comparison of cardiovascular risk factors in European population cohorts for predicting atrial fibrillation and heart failure, their subsequent onset, and death
Comparison of cardiovascular risk factors in European population cohorts for predicting atrial fibrillation and heart failure, their subsequent onset, and death Open
Background Differences in risk factors for atrial fibrillation (AF) and heart failure (HF) are incompletely understood. Aim of this study was to understand whether risk factors and biomarkers show different associations with incident AF an…
View article: Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis
Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis Open
BACKGROUND: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentratio…
View article: Cardiac troponin I and incident stroke in European cohorts - insights from the BiomarCaRE project
Cardiac troponin I and incident stroke in European cohorts - insights from the BiomarCaRE project Open
Background and Purpose: Stroke is a common cause of death and a leading cause of disability and morbidity. Stroke risk assessment remains a challenge, but circulating biomarkers may improve risk prediction. Controversial evidence is availa…
View article: Association between the gut microbiota and blood pressure in a population cohort of 6953 individuals
Association between the gut microbiota and blood pressure in a population cohort of 6953 individuals Open
Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted assoc…
View article: Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality
Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality Open
Aims Limited evidence is available on the temporal relationship between atrial fibrillation (AF) and ischaemic stroke and their impact on mortality in the community. We sought to understand the temporal relationship of AF and ischaemic str…
View article: Letter to the Editor Regarding "Public Health Approaches to Type 2 Diabetes Prevention: The US National Diabetes Prevention Program and Beyond"
Letter to the Editor Regarding "Public Health Approaches to Type 2 Diabetes Prevention: The US National Diabetes Prevention Program and Beyond" Open
Letter to the Editor Regarding “Public Health Approaches to Type 2 Diabetes Prevention: The US National Diabetes Prevention Program and Beyond”
View article: The North Karelia Project: Cardiovascular disease prevention in Finland
The North Karelia Project: Cardiovascular disease prevention in Finland Open
The extremely high cardiovascular mortality in an eastern province North Karelia in Finland caused great concern among the local population. Action to reduce the problem was demanded in a petition to the Finnish government signed by local …
View article: Seasonality, morningness-eveningness, and sleep in common non - communicable medical conditions and chronic diseases in a population
Seasonality, morningness-eveningness, and sleep in common non - communicable medical conditions and chronic diseases in a population Open
Introduction The seasonal pattern for mood and behaviour, the behavioural trait of morningness-eveningness, and sleep are interconnected features, that may serve as etiological factors in the development or exacerbation of medical conditio…
View article: Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies
Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies Open
Background: Several studies have shown that diabetes confers a higher relative risk of vascular mortality among women than among men, but whether this increased relative risk in women exists across age groups and within defined levels of o…