David E. Whitworth YOU? Author Swipe

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Milestones in the development of <i>Myxococcus xanthus</i> as a model multicellular bacterium Open

Lee Kroos, Daniel Wall, Salim T. Islam, David E. Whitworth, José Muñoz‐Dorado , et al. · 2025

From the humblest of beginnings (i.e. a pile of dry cow dung) over 80 years ago, the Gram-negative bacterium Myxococcus xanthus has emerged as a premier model system for studying diverse fields of bacteriology, including multicellular deve…

Myxobacteria from soil can substantially reduce the bacterial load in a wound infection model Open

Benita S Arakal, Richard S. Rowlands, Sarah Maddocks, David E. Whitworth, Philip E. James , et al. · 2024

Aims Myxobacteria are non-pathogenic, saprophytic, soil-dwelling predatory bacteria known for their antimicrobial potential. Many pathogenic bacteria form biofilms to protect themselves from antimicrobial agents and the immune system. This…

Filamentary Molecular Cloud Formation via Collision-induced Magnetic Reconnection in Cold Neutral Medium Open

Shuo Kong, Rowan J. Smith, David E. Whitworth, Erika T. Hamden · 2024

We have investigated the possibility of molecular cloud formation via the Collision-induced Magnetic Reconnection (CMR) mechanism of the cold neutral medium (CNM). Two atomic gas clouds with conditions typical of the CNM were set to collid…

Editorial: Biology of myxobacteria Open

Zhoukun Li, Honghui Zhu, David E. Whitworth, David C. Stevens · 2024

Keywords: developmental biology, predation biology, fruiting body, bacterial communication, biological control, soil ecosystems

<i>Corallococcus senghenyddensis</i> sp. nov., a myxobacterium with potent antimicrobial activity Open

Benita S Arakal, Richard S. Rowlands, Michael McCarthy, David E. Whitworth, Sarah Maddocks , et al. · 2024

Aim Corallococcus species are diverse in the natural environment with 10 new Corallococcus species having been characterized in just the last 5 years. As well as being an abundant myxobacterial genus, they produce several secondary metabol…

MyxoPortal: a database of myxobacterial genomic features Open

Rayapadi G Swetha, Benita S Arakal, Santhosh Rajendran, K. Sekar, David E. Whitworth , et al. · 2024

Myxobacteria are predatory bacteria with antimicrobial activity, utilizing complex mechanisms to kill their prey and assimilate their macromolecules. Having large genomes encoding hundreds of secondary metabolites, hydrolytic enzymes and a…

The RNA cargo of <i>Myxococcus</i> outer membrane vesicles Open

Martin Swain, Emily Jade Radford, Allison S. Akanyeti, James H. Hallwood, David E. Whitworth · 2023

Vesicles secreted by predatory myxobacteria contain RNA transcripts. Many transcripts seem to be packaged passively, but others seem to be specifically loaded onto vesicles.

Identification of secondary metabolites containing a diketopiperazine core in extracts from myxobacterial strains with growth inhibition activity against a range of prey species Open

Emily Jade Radford, David E. Whitworth, Gordon Allison · 2023

Myxobacteria produce a variety of bioactive secondary metabolites, and with a wealth of under-researched species they hold vast potential for undiscovered compounds. With the ever-increasing need for new antibiotics, the development of nov…

Identification of secondary metabolites containing a diketopiperazine core in extracts from myxobacterial strains with growth inhibition activity against a range of prey species Open

Emily Jade Radford, David E. Whitworth, Gordon Allison · 2023

Myxobacteria produce a variety of bioactive secondary metabolites, and with a wealth of under-researched species they hold vast potential for undiscovered compounds. With the ever-increasing need for new antibiotics, the development of nov…

Identification of secondary metabolites containing a diketopiperazine core in extracts from myxobacterial strains with growth inhibition activity against a range of prey species Open

Emily Jade Radford, David E. Whitworth, Gordon Allison · 2023

Myxobacteria produce a variety of bioactive secondary metabolites, and with a wealth of under-researched species they hold vast potential for undiscovered compounds. With the ever-increasing need for new antibiotics, the development of nov…

Editorial: Mechanisms of prokaryotic predation, volume II Open

David E. Whitworth, Juana Pérez, Robert J. Mitchell, Samay Pande · 2023

Citation: Whitworth DE, Pérez J, Mitchell RJ and Pande S (2023) Editorial: Mechanisms of prokaryotic predation, volume II. Front. Microbiol. 14:1256252. doi: 10.3389/fmicb.2023.1256252

Reviewer response for version 1 Open

Emily Jade Radford, David E. Whitworth, Gordon Allison · 2023

Myxobacteria produce a variety of bioactive secondary metabolites, and with a wealth of under-researched species they hold vast potential for undiscovered compounds. With the ever-increasing need for new antibiotics, the development of nov…

Reviewer response for version 1 Open

Emily Jade Radford, David E. Whitworth, Gordon Allison · 2023

Myxobacteria produce a variety of bioactive secondary metabolites, and with a wealth of under-researched species they hold vast potential for undiscovered compounds. With the ever-increasing need for new antibiotics, the development of nov…

Identification of secondary metabolites containing a diketopiperazine core in extracts from myxobacterial strains with growth inhibition activity against a range of prey species Open

Emily Jade Radford, David E. Whitworth, Gordon Allison · 2023

Myxobacteria produce a variety of bioactive secondary metabolites, and with a wealth of under-researched species they hold vast potential for undiscovered compounds. With the ever-increasing need for new antibiotics, the development of nov…

Predatory Strategies of Myxococcus xanthus: Prey Susceptibility to OMVs and Moonlighting Enzymes Open

Allison S. Zwarycz, Thomas Page, Gabriela Nikolova, Emily Jade Radford, David E. Whitworth · 2023

Predatory outer membrane vesicles (OMVs) secreted by myxobacteria fuse readily with the outer membranes of Gram-negative bacteria, introducing toxic cargo into their prey. Here we used a strain of the myxobacterium Myxococcus xanthus that …

Myxobacterial Predation: A Standardised Lawn Predation Assay Highlights Strains with Unusually Efficient Predatory Activity Open

Allison S. Zwarycz, David E. Whitworth · 2023

Myxobacteria prey upon a broad range of microorganisms. Lawn assays are commonly used to quantify myxobacterial predation—myxobacterial suspensions are spotted onto prey lawns, and monitored via spot expansion. The diversity in motility be…

On the distribution of the Cold Neutral Medium in galaxy discs Open

Rowan J. Smith, Robin G. Treß, J. D. Soler, Ralf S. Klessen, Simon C. O. Glover , et al. · 2023

The Cold Neutral Medium (CNM) is an important part of the galactic gas cycle and a precondition for the formation of molecular and star forming gas, yet its distribution is still not fully understood. In this work we present extremely high…

A Synthetic Polymicrobial Community Biofilm Model Demonstrates Spatial Partitioning, Tolerance to Antimicrobial Treatment, Reduced Metabolism, and Small Colony Variants Typical of Chronic Wound Biofilms Open

Ammara Khalid, Alan Cookson, David E. Whitworth, Michael L. Beeton, Lori I. Robins , et al. · 2023

Understanding chronic wound infection is key for successful treatment and requires accurate laboratory models. We describe a modified biofilm flow device that effectively mimics the chronic wound environment, including simulated wound flui…

In Silico and In Vitro Analyses Reveal Promising Antimicrobial Peptides from Myxobacteria Open

Benita S Arakal, David E. Whitworth, Philip E. James, Richard S. Rowlands, Neethu P. T. Madhusoodanan , et al. · 2022

Editorial: Microbial mitigation of hazardous compounds in agro-ecosystems Open

Devanita Ghosh, David E. Whitworth, Hendrik Schäfer, Srinivasan Krishnamurthi, Pradipta Saha · 2022

Currently, many agro-ecosystems are contaminated with toxic, hazardous compounds which can be broadly categorized as (a) anthropocentrically introduced xenobiotic agrochemicals (e.g., pesticides, insecticides, and fungicides), (b) secondar…

Filament Formation via Collision-induced Magnetic Reconnection -- Formation of a Star Cluster Open

Shuo Kong, David E. Whitworth, Rowan J. Smith, Erika Hamden · 2022

A collision-induced magnetic reconnection (CMR) mechanism was recently proposed to explain the formation of a filament in the Orion A molecular cloud. In this mechanism, a collision between two clouds with antiparallel magnetic fields prod…

Insilico and Invitro Analyses Reveal Promising Antimicrobial Peptides from Myxobacteria Open

Benita S Arakal, David E. Whitworth, Philip E. James, Richard S. Rowlands, Neethu P. T. Madhusoodanan , et al. · 2022

Antimicrobial resistance (AMR) is a global concern, and as soon as new antibiotics are introduced, resistance to those agents emerges. Therefore, there is an increased appetite for alternative antimicrobial agents to traditional antibiotic…

Increasing creative self‐efficacy: Developing the confidence of biochemistry undergraduates to innovate Open

Simon Mark Payne, David E. Whitworth · 2022

Biochemistry graduates need to be creative, however assessing creativity requires the production of novelty, judged by or against that of peers. A related phenomenon is ‘creative self‐efficacy’ (CSE) – one's self‐belief in producing creati…

Myxobacteria Open

David E. Whitworth · 2022

Myxobacteria are fascinating and important prokaryotes. They have large genomes and exhibit a wide range of interesting behaviors, including multicellular fruiting body formation, social interaction, predation, and secondary metabolite pro…

Myxobacteria: Physiology and Regulation Open

David E. Whitworth · 2022

Myxobacteria are fascinating and important prokaryotes [...]

Myxobacterial Genomics and Post-Genomics: A Review of Genome Biology, Genome Sequences and Related ‘Omics Studies Open

David E. Whitworth, Natashia Sydney, Emily Jade Radford · 2021

Myxobacteria are fascinating and complex microbes. They prey upon other members of the soil microbiome by secreting antimicrobial proteins and metabolites, and will undergo multicellular development if starved. The genome sequence of the m…

Evolutionary history expands the range of signaling interactions in hybrid multikinase networks Open

Philippe Ortet, Sylvain Fochesato, Anne‐Florence Bitbol, David E. Whitworth, David Lalaouna , et al. · 2021

Corrigendum to “Comparative genomics and pan-genomics of the Myxococcaceae, including a description of five novel species: <i>Myxococcus eversor</i> sp. nov., <i>Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis</i> sp. nov., <i>Myxococcus vastator</i> sp. nov., <i>Pyxidicoccus caerfyrddinensis</i> sp. nov. and <i>Pyxidicoccus trucidator</i> sp. nov.” [Genome Biol. Evol. 12(12) (2020) 2289-2302] Open

James Chambers, Natalie Sparks, Natashia Sydney, Paul G. Livingstone, Alan Cookson , et al. · 2021

The Genetics of Prey Susceptibility to Myxobacterial Predation: A Review, Including an Investigation into <b><i>Pseudomonas aeruginosa</i></b> Mutations Affecting Predation by <b><i>Myxococcus xanthus</i></b> Open

Natashia Sydney, Martin Swain, Jeffery Man To So, Egbert Hoiczyk, Nicholas P. Tucker , et al. · 2021

Bacterial predation is a ubiquitous and fundamental biological process, which influences the community composition of microbial ecosystems. Among the best characterised bacterial predators are the myxobacteria, which include the model orga…

A Genomic Survey of Signalling in the Myxococcaceae Open

David E. Whitworth, Allison S. Zwarycz · 2020

As prokaryotes diverge by evolution, essential ‘core’ genes required for conserved phenotypes are preferentially retained, while inessential ‘accessory’ genes are lost or diversify. We used the recently expanded number of myxobacterial gen…

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