H.‐Erich Wichmann
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View article: Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls
Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls Open
Background Although the associations between genetic variations and lung cancer risk have been explored, the epigenetic consequences of DNA methylation in lung cancer development are largely unknown. Here, the genetically predicted DNA met…
View article: Identification of ten loci associated with height highlights new biological pathways in human growth
Identification of ten loci associated with height highlights new biological pathways in human growth Open
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million S…
Metabolomic Fingerprints in Large Population Cohorts: Impact of Preanalytical Heterogeneity Open
Metabolomics studies have provided new insights into molecular disease mechanisms and individual response to treatment. Large scale metabolomics studies can greatly contribute to building a solid data and knowledge basis for future disease…
View article: Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development Open
The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing…
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population Open
Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs…
View article: Quality Matters: 2016 Annual Conference of the National Infrastructures for Biobanking
Quality Matters: 2016 Annual Conference of the National Infrastructures for Biobanking Open
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