Eamonn Eeles
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View article: Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux
Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux Open
Brain waste is cleared via a cerebrospinal fluid (CSF) pathway, the glymphatic system, whose dysfunction may underlie many brain conditions. Previous studies show coherent vascular oscillation, measured by blood oxygenation level-dependent…
View article: Pilot implementation of an electronic diagnostic support tool (AiD‐DST) designed to identify the cause(s) of delirium
Pilot implementation of an electronic diagnostic support tool (AiD‐DST) designed to identify the cause(s) of delirium Open
Objective(s) The identification of cause(s) of delirium remains a clinical challenge within medicine. Our group have previously successfully developed and tested the Aetiology in Delirium—Decision Support Tool (AiD‐DST). The AiD‐DST is des…
View article: Schrödinger’s cat and mouse: An adapted thought experiment for the context of consciousness
Schrödinger’s cat and mouse: An adapted thought experiment for the context of consciousness Open
Consciousness, at its simplest, represents awareness of self in relation to the outside world. This can be divided further into the reasoning and rationality of Access consciousness (A-C) versus the experiential and 'what it's like' of Phe…
View article: Sleep fragmentation and hypoxaemia as key indicators of cognitive impairment in patients with obstructive sleep apnoea
Sleep fragmentation and hypoxaemia as key indicators of cognitive impairment in patients with obstructive sleep apnoea Open
Background This study aimed to identify characteristics associated with cognitive impairment in older individuals with obstructive sleep apnoea (OSA) using the Addenbrooke’s Cognitive Examination-Revised (ACE-R) that could aid in stratifyi…
View article: Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux
Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux Open
Waste from the brain is cleared via a cerebrospinal fluid (CSF) exchange pathway, the dysfunction of which is suggested to underlie the pathogenesis of many brain conditions. Coherent cerebrovascular oscillation that couples with pulsatile…
View article: Sleep Fragmentation and Hypoxaemia as Key Indicators of Cognitive Impairment in Patients with Obstructive Sleep Apnoea
Sleep Fragmentation and Hypoxaemia as Key Indicators of Cognitive Impairment in Patients with Obstructive Sleep Apnoea Open
Background This study aimed to characterize the prevalence of cognitive impairment in older individuals with obstructive sleep apnoea (OSA) using the Addenbrooke's Cognitive Examination-Revised (ACE-R), and to identify characteristics asso…
View article: Face and content validity of a mobile delirium screening tool adapted for use in the medical setting (eDIS‐MED): Welcome to the machine
Face and content validity of a mobile delirium screening tool adapted for use in the medical setting (eDIS‐MED): Welcome to the machine Open
Objectives Following a user‐centred redesign and refinement process of an electronic delirium screening tool (eDIS‐MED), further accuracy assessment was performed prior to anticipated testing in the clinical setting. Methods Content validi…
View article: A narrative review of the development and performance characteristics of electronic delirium-screening tools
A narrative review of the development and performance characteristics of electronic delirium-screening tools Open
Electronic delirium-screening tools are an exciting area of development and may offer hope for improved uptake of delirium screening.
View article: Adaptation of an electronic delirium screening tool for use in the medical setting based on a human centered design approach
Adaptation of an electronic delirium screening tool for use in the medical setting based on a human centered design approach Open
Background Delirium is frequently missed in clinical practice. We used a user-centred redesign process to evaluate and adapt an existing electronic delirium screening tool (eDIS-ICU) for use in the medical setting. Methods In phase 1, we c…
View article: Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment
Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment Open
Background Dysfunction of the cholinergic basal forebrain (BF) neurotransmitter system, including cholinergic axon denervation of the cortex, plays an important role in cognitive decline and dementia. The association of cortical cholinergi…
View article: 1336 TOWARDS AN UNDERSTANDING OF THE BIOLOGICAL MECHANISMS OF DELIRIUM USING FUNCTIONAL MRI: PILOT STUDY
1336 TOWARDS AN UNDERSTANDING OF THE BIOLOGICAL MECHANISMS OF DELIRIUM USING FUNCTIONAL MRI: PILOT STUDY Open
Introduction Delirium is a common condition in older hospitalised patients causing high morbidity and mortality. The neurobiological basis for delirium is uncertain and, for numerous reasons, research in this area has been limited. Several…
View article: Pilot testing of a new electronic diagnostic support tool (AiD-DST) designed to identify the cause(s) of delirium
Pilot testing of a new electronic diagnostic support tool (AiD-DST) designed to identify the cause(s) of delirium Open
Introduction Delirium is frequently multifactorial, and causes are often missed in clinical practice. The Aetiology in Delirium - Diagnostic Support Tool (AiD-DST) was developed to improve recognition of the causes. We undertook an evaluat…
View article: P141 High prevalence of obstructive sleep apnoea in patients with mild cognitive impairment or mild dementia
P141 High prevalence of obstructive sleep apnoea in patients with mild cognitive impairment or mild dementia Open
Aims Obstructive sleep apnoea (OSA) occurs with greater frequency in advancing age. The resulting sleep fragmentation and oxygen desaturations may induce or contribute to neurodegeneration. As such, OSA may be an important modifiable risk …
View article: A delicate balance: Psychotropic polypharmacy and anti‐cholinergic use are correlated with fall incidence in Australian inpatients with dementia
A delicate balance: Psychotropic polypharmacy and anti‐cholinergic use are correlated with fall incidence in Australian inpatients with dementia Open
Background Persons with dementia commonly experience a range of beh avioural and psychological symptoms, including agitation, aggression, perceptual disturbances, and depression. While psychotropic medications are regularly prescribed to m…
View article: Development and validation of an aetiology in delirium diagnostic support tool
Development and validation of an aetiology in delirium diagnostic support tool Open
Background recognition of the multifactorial causes of delirium represents a clinical challenge. Objectives to develop and show proof of principle of a diagnostic support tool (DST) for identification of causes of delirium. Methods stage 1…
View article: Understanding our patients better will lead to better recognition of delirium: An opinion piece
Understanding our patients better will lead to better recognition of delirium: An opinion piece Open
Delirium is a temporary condition involving a disturbance in attention, cognition and awareness. Typically, it develops over a relatively short time frame and fluctuates in severity. Delirium is preventable in one‐third of cases, and early…
View article: Consciousness, Functional Networks and Delirium Screening
Consciousness, Functional Networks and Delirium Screening Open
BACKGROUND: Consciousness, the medium of sentient thought, requires integrity of functional networks and their connectivity. In health, they function as a co-operative but mutually exclusive paradigm of introspection versus external awaren…
View article: Neurological Injury in Intermediate‐Risk Transcatheter Aortic Valve Implantation
Neurological Injury in Intermediate‐Risk Transcatheter Aortic Valve Implantation Open
Background The application of transcatheter aortic valve implantation ( TAVI ) to intermediate‐risk patients is a controversial issue. Of concern, neurological injury in this group remains poorly defined. Among high‐risk and inoperable pat…
View article: Water, water everywhere: Dehydration in the midst of plenty: An observational study of barriers and enablers to adequate hydration in older hospitalized patients
Water, water everywhere: Dehydration in the midst of plenty: An observational study of barriers and enablers to adequate hydration in older hospitalized patients Open
While dehydration is common in older patients and is associated with poor outcomes, it has been infrequently studied in the hospital setting. Thus, the aim of this study was to identify potential barriers and enablers to the maintenance of…
View article: Water, water everywhere: dehydration in the midst of plenty – An observational study of barriers and enablers to adequate hydration in older hospitalized patients
Water, water everywhere: dehydration in the midst of plenty – An observational study of barriers and enablers to adequate hydration in older hospitalized patients Open
While dehydration is common in older patients and is associated with poor outcomes, it has been infrequently studied in the hospital setting. Thus, the aim of this study was to identify potential barriers and enablers to the maintenance of…
View article: Hospitals in the home for patients with delirium: No place like home?
Hospitals in the home for patients with delirium: No place like home? Open
Background: Management of patients with delirium presents a challenge. Aims: Supported discharge with Hospital in the Home (HITH) for patients with delirium was developed and evaluated. Methods: Patients admitted acutely to internal medici…
View article: Associations between dehydration, cognitive impairment and frailty in older hospitalized patients: An exploratory study
Associations between dehydration, cognitive impairment and frailty in older hospitalized patients: An exploratory study Open
An exploratory study was undertaken to assess the prevalence of dehydration in older patients (aged ≥60 years) with and without cognitive impairment (CI) admitted to hospital and to examine associations between dehydration, CI and frailty.…