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View article: Scanning Tunneling Microscope Measurement of Proteasome Conductance
Scanning Tunneling Microscope Measurement of Proteasome Conductance Open
The proteasome is an enzyme that sequentially degrades peptides into small fragments, so the ability to make electrical measurements of its conformational fluctuations could lead to an electronic readout of the sequence of single peptide m…
View article: Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues
Heavy Water Reduces the Electronic Conductance of Protein Wires via Deuteron Interactions with Aromatic Residues Open
Proteins are versatile, self-assembling nanoelectronic components, but their hopping conductivity is expected to be influenced by solvent fluctuations. The role of the solvent was investigated by measuring the single molecule conductance o…
View article: Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins
Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins Open
DNA molecular wires have been studied extensively because of the ease with which molecules of controlled length and composition can be synthesized. The same has not been true for proteins. Here, we have synthesized and studied a series of …
View article: Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide Open
Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities…
View article: Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency
Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency Open
As molecular electronic components, proteins are distinguished by a remarkably long electronic decay length (∼10 nm) together with high contact resistance and extreme sensitivity to the chemical details of the contact. As a consequence, th…
View article: Pleiotrophin interacts with glycosaminoglycans in a highly flexible and adaptable manner
Pleiotrophin interacts with glycosaminoglycans in a highly flexible and adaptable manner Open
Pleiotrophin (PTN) is a potent mitogenic cytokine whose activities are controlled by its interactions with glycosaminoglycan (GAG). We examined the specificity of PTN for several types of GAG oligosaccharides. Our data indicate that the in…
View article: Structural studies reveal an important role for the pleiotrophin C‐terminus in mediating interactions with chondroitin sulfate
Structural studies reveal an important role for the pleiotrophin C‐terminus in mediating interactions with chondroitin sulfate Open
Pleiotrophin ( PTN ) is a potent glycosaminoglycan‐binding cytokine that is important in neural development, angiogenesis and tissue regeneration. Much of its activity is attributed to its interactions with the chondroitin sulfate ( CS ) p…