Ebba K. Blomqvist
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View article: MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes
MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes Open
SUMMARY Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus that antagonizes innate immune responses, including the protein kinase R (PKR) pathway. Here, we examine the process of PKR activation in response…
View article: Cell sorting based on single nucleotide variation enables characterization of mutation-dependent transcriptome and chromatin states
Cell sorting based on single nucleotide variation enables characterization of mutation-dependent transcriptome and chromatin states Open
Point mutations in oncogenes and tumor suppressor genes are common drivers of tumorigenesis. Moreover, single nucleotide variants (SNVs) also contribute to cancer by altering the noncoding regions of the genome. However, connecting SNVs to…
View article: Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus Open
Oligoadenylate synthetases (OASs) are ancient proteins that play a critical role in combatting viruses in mammals. OASs are known to antagonize viral replication by binding viral dsRNA and synthesizing 2′–5′-oligo(A), which activates the a…
View article: SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling Open
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of deaths since its emergence in 2019. Innate immune antagonism by lethal CoVs such as SARS-CoV-2 is crucial for optimal replication and pathogenesis. The conse…
View article: Unstructured Domains in Assembly Factors Promote the Hierarchy of Ribosome Maturation via Their Structural Plasticity
Unstructured Domains in Assembly Factors Promote the Hierarchy of Ribosome Maturation via Their Structural Plasticity Open
Ribosomes are assembled with the help of a large machinery of assembly factors (AFs), whose roles remain incompletely characterized. Recent structural studies of assembly intermediates have provided tremendous context for such studies and …
View article: A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head
A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head Open
Ribosomes are complex macromolecules assembled from 4 rRNAs and 79 ribosomal proteins (RPs). Their assembly is organized in a highly hierarchical manner, which is thought to avoid dead-end pathways, thereby enabling efficient assembly of r…
View article: A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head
A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head Open
Ribosomes are complex macromolecules assembled from 4 rRNAs and 79 ribosomal proteins (RPs). Their assembly is organized in a highly hierarchical manner, which is thought to avoid dead-end pathways, thereby enabling efficient assembly of r…