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View article: Cell Contractile Force‐Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds
Cell Contractile Force‐Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds Open
Tissue morphogenesis is a critical aspect of tissue development. Recent advances in 4D cell scaffolds have shown promise for modeling morphogenetic processes. While current 4D systems often rely on external stimuli, they frequently overloo…
View article: In situ cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels
In situ cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels Open
Formation of chondromimetic human mesenchymal stem cell (hMSC) condensations typically requires in vitro culture in defined environments. In addition, extended in vitro culture in differentiation media over several weeks is usually necessa…
View article: A 4D Bio-Kirigami Strategy for Engineering Complex Tissue Curvatures
A 4D Bio-Kirigami Strategy for Engineering Complex Tissue Curvatures Open
Four-dimensional (4D) systems offer a promising approach for generating sophisticated dynamic structures that mimic native tissue architectures. Among those, Kirigami strategies enable precise, localized control over morphing behaviors, ye…
View article: The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants
The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants Open
Shape‐memory thermomorphs (SMTMs) are materials that undergo morphological changes when subjected to external heat stimulation. The rapid evolution of additive manufacturing has significantly propelled advancements in SMTM research and its…
View article: CYR61 delivery promotes angiogenesis during bone fracture repair
CYR61 delivery promotes angiogenesis during bone fracture repair Open
Compromised vascular supply and insufficient neovascularization impede bone repair, increasing risk of non-union. CYR61, Cysteine-rich angiogenic inducer of 61kD (also known as CCN1), is a matricellular growth factor that has been implicat…
View article: Photocrosslinkable and biodegradable hydrogels for the controlled delivery of exosomes
Photocrosslinkable and biodegradable hydrogels for the controlled delivery of exosomes Open
Local and controlled delivery of exosomes using hydrogels can improve the efficacy of exosome-based therapeutics. Hydrogels based on oxidized and methacrylated alginate (OMA) can be produced through photocrosslinking and exhibit controllab…
View article: <i>In situ</i> cell-only bioprinting of patterned prevascular tissue into bioprinted high-density stem cell-laden microgel bioinks for vascularized bone tissue regeneration
<i>In situ</i> cell-only bioprinting of patterned prevascular tissue into bioprinted high-density stem cell-laden microgel bioinks for vascularized bone tissue regeneration Open
Recently, microgels have been widely used in three-dimensional (3D) bioprinting as both supporting baths and bioinks. As a bioink, microgels have several unique properties, such as shear-thinning and self-healing behaviors with tunable mec…
View article: Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions
Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions Open
Phenotypic screening of cell-cell and cell-matrix interactions is critical yet challenging for drug discovery and disease modeling. In this study, a scalable 3D tissue platform was developed by co-laying extracted natural insoluble collage…
View article: Cell Contractile Force-Mediated Morphodynamical Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds
Cell Contractile Force-Mediated Morphodynamical Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds Open
Tissue morphogenesis is a critical aspect tissue development. Recent advances in four-dimensional (4D) cell scaffolds have shown promise for modeling morphogenic processes. While current 4D systems often rely on external stimuli, they tend…
View article: Reprogrammable 4D Tissue Engineering Hydrogel Scaffold via Reversible Ion Printing
Reprogrammable 4D Tissue Engineering Hydrogel Scaffold via Reversible Ion Printing Open
Shape changeable hydrogel scaffolds recapitulating morphological dynamism of native tissues have emerged as an elegant tool for future tissue engineering (TE) applications, due to their capability to create morphodynamical tissues with com…
View article: Clickable PEG-norbornene microgels support suspension bioprinting and microvascular assembly
Clickable PEG-norbornene microgels support suspension bioprinting and microvascular assembly Open
The development of perfusable and multiscale vascular networks remains one of the largest challenges in tissue engineering. As such, there is a need for the creation of customizable and facile methods to produce robustly vascularized const…
View article: Cell Contractile Forces Drive Spatiotemporal Morphing in 4D Bioprinted Living Constructs
Cell Contractile Forces Drive Spatiotemporal Morphing in 4D Bioprinted Living Constructs Open
Current 4D materials typically rely on external stimuli such as heat or light to accomplish changes in shape, limiting the biocompatibility of these materials. Here, a composite bioink consisting of oxidized and methacrylated alginate (OMA…
View article: Biofabrication of engineered tissues by 3D bioprinting of tissue specific high cell-density bioinks
Biofabrication of engineered tissues by 3D bioprinting of tissue specific high cell-density bioinks Open
Bioprinting of high cell-density bioinks is a promising technique for cellular condensation-based tissue engineering and regeneration medicine. However, it remains difficult to create precisely controlled complex structures and organizatio…
View article: <i>In situ</i>cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels
<i>In situ</i>cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels Open
Formation of chondromimetic human mesenchymal stem cells (hMSCs) condensations typically required in vitro culture in defined environments. In addition, extended in vitro culture in differentiation media over several weeks is usually neces…
View article: Cyr61 delivery promotes angiogenesis during bone fracture repair
Cyr61 delivery promotes angiogenesis during bone fracture repair Open
Compromised vascular supply and insufficient neovascularization impede bone repair, increasing risk of non-union. Cyr61, Cysteine-rich angiogenic inducer of 61kD (also known as CCN1), is a matricellular growth factor that is regulated by m…
View article: Jammed Micro‐Flake Hydrogel for Four‐Dimensional Living Cell Bioprinting
Jammed Micro‐Flake Hydrogel for Four‐Dimensional Living Cell Bioprinting Open
Adv. Mater. 2022, 34, 202109394 DOI: 10.1002/adma.202109394 This correction has no impact on the results or scientific conclusions of the article.
View article: A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis
A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis Open
Human organoids have the potential to revolutionize in vitro disease modeling by providing multicellular architecture and function that are similar to those in vivo. This innovative and evolving technology, however, still suffers from assa…
View article: Optimizing Bioink Composition for Human Chondrocyte Expression of Lubricin
Optimizing Bioink Composition for Human Chondrocyte Expression of Lubricin Open
The surface zone of articular cartilage is the first area impacted by cartilage defects, commonly resulting in osteoarthritis. Chondrocytes in the surface zone of articular cartilage synthesize and secrete lubricin, a proteoglycan that fun…
View article: Hybrid Vesicles Enable Mechano‐Responsive Hydrogel Degradation
Hybrid Vesicles Enable Mechano‐Responsive Hydrogel Degradation Open
Stimuli‐responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano‐responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable st…
View article: Hybrid Vesicles Enable Mechano‐Responsive Hydrogel Degradation
Hybrid Vesicles Enable Mechano‐Responsive Hydrogel Degradation Open
Stimuli‐responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano‐responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable st…
View article: Development of mechanosensitive synthetic cells for biomedical applications
Development of mechanosensitive synthetic cells for biomedical applications Open
The ability of cells to sense and respond to their physical environment plays a fundamental role in a broad spectrum of biological processes. As one of the most essential molecular force sensors and transducers found in cell membranes, mec…
View article: Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation
Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation Open
Stimuli-responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano-responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable st…
View article: A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis
A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis Open
Human organoids have potential to revolutionize in vitro disease modeling by providing multicellular architecture and function that are similar to those in vivo . This innovative and evolving technology, however, still suffers from assay t…
View article: Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition
Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition Open
Poor nutrient transport through the cartilage endplate (CEP) is a key factor in the etiology of intervertebral disc degeneration and may hinder the efficacy of biologic strategies for disc regeneration. Yet, there are currently no treatmen…
View article: Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel
Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel Open
Salivary gland acinar cells are severely depleted after radiotherapy for head and neck cancer, leading to loss of saliva and extensive oro-digestive complications. With no regenerative therapies available, organ dysfunction is irreversible…
View article: Optimizing bioink composition for human chondrocyte expression of lubricin
Optimizing bioink composition for human chondrocyte expression of lubricin Open
The surface zone of articular cartilage is the first area impacted by cartilage defects, commonly resulting in osteoarthritis. Chondrocytes in the surface zone of articular cartilage synthesize and secrete lubricin, a proteoglycan that fun…