Explanipedia

Accuracy of cobas MTB and MTB-RIF/INH for Detection of Mycobacterium tuberculosis and Drug Resistance Open

Margaretha de Vos, Anura David, Karthickeyan Duraisamy, Darshaalini Nadarajan, Ecaterina Noroc , et al. · 2024

This study evaluated the performance of cobas MTB and cobas MTB-RIF/INH for the diagnosis of tuberculosis and detection of rifampicin (RIF) and isoniazid (INH) resistance. Adults presenting with pulmonary tuberculosis symptoms were recruit…

Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova Open

Ecaterina Noroc, Dumitru Chesov, Matthias Merker, Matthias I. Gröschel, Ivan Barilar , et al. · 2023

Applying whole-genome-sequencing, we aimed to detect transmission events of multidrug-resistant/rifampin-resistant strains of Mycobacterium tuberculosis complex at a tuberculosis hospital in Chisinau, Moldova. We recorded ward, room, and b…

Diagnostic Capacities for Multidrug-Resistant Tuberculosis in the World Health Organization European Region Open

Florian P. Maurer, Natalia Shubladze, Gulmira Kalmambetova, Irina Felker, Giorgi Kuchukhidze , et al. · 2022

Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study Open

Iris Finci, Audrey Albertini, Matthias Merker, Sönke Andres, Nino Bablishvili , et al. · 2022

Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova Open

Tyler S. Brown, Vegard Eldholm, Ola Brynildsrud, Magnus N Osnes, Natalie S. Levy , et al. · 2021

The evolution and emergence of drug-resistant tuberculosis (TB) has been studied extensively in some contexts, but the ecological drivers of these two processes remain poorly understood. This study sought to describe the joint evolutionary…

Levels of phenotypic resistance and the pattern of gene mutations of M. tuberculosis Open

Nelly Ciobanu, Alexandru Codreanu, Nadejda Turcan, Ecaterina Noroc, Valeriu Crudu · 2021

The adjustment of the minimum inhibitory concentrations for anti-tuberculosis drugs used in classical cultivation methods and the obtaining of more accurate data on the level of drug resistance, makes it possible to evaluate cases with dif…

Evolution and emergence of multidrug-resistant <i>Mycobacterium tuberculosis</i> in Chisinau, Moldova Open

Tyler S. Brown, Vegard Eldholm, Ola Brynildsrud, Magnus N Osnes, Natalie Stennis , et al. · 2021

1. ABSTRACT Background Drug-resistant tuberculosis is a high priority threat to global public health. There are still critical gaps in understanding how novel drug-resistant M. tuberculosis strains emerge and, once emergent, what drives th…

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance Open

Abigail L. Manson, Keira A. Cohen, Thomas Abeel, Christopher A. Desjardins, Derek T. Armstrong , et al. · 2017

In reply Open

Matthias Merker, Valeriu Crudu, Ecaterina Noroc, Elena Romancenco, Dumitru Chesov , et al. · 2016

Comparison of observed error rate for SMOR analysis versus standard NGS analysis on a pure pan-susceptible <i>Mycobacterium tuberculosis</i> isolate across the entire amplicon. Open

E. Colman Rebecca, M. Schupp James, D. Hicks Nathan, E. Smith David, Lanetta Jordan , et al. · 2015

Comparison of observed error rate for SMOR analysis versus standard NGS analysis on a pure pan-susceptible Mycobacterium tuberculosis isolate across the entire amplicon.

Nosocomial transmission of multidrug-resistant tuberculosis Open

Valeriu Crudu, Matthias Merker, Christoph Lange, Ecaterina Noroc, Elena Romancenco , et al. · 2015

Nosocomial transmission of multidrug-resistant tuberculosis (MDR-TB) was ascertained by 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) and spoligotyping at four hospitals in the Republic …

Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing Open

Rebecca E. Colman, James M. Schupp, Nathan Hicks, David Smith, Jordan L. Buchhagen , et al. · 2015

Undetected and untreated, low-levels of drug resistant (DR) subpopulations in clinical Mycobacterium tuberculosis (Mtb) infections may lead to development of DR-tuberculosis, potentially resulting in treatment failure. Current phenotypic D…

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