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View article: Neoadjuvant Pembrolizumab Plus Chemotherapy in Early-Stage Triple-Negative Breast Cancer: A Nationwide Retrospective Turkish Oncology Group Study
Neoadjuvant Pembrolizumab Plus Chemotherapy in Early-Stage Triple-Negative Breast Cancer: A Nationwide Retrospective Turkish Oncology Group Study Open
Background/Objectives: Following the results of the phase 3 KEYNOTE-522 trial, the U.S. Food and Drug Administration approved pembrolizumab, a humanized IgG4 kappa monoclonal antibody, in combination with neoadjuvant chemotherapy as a new …
View article: Prosigna Assay for Treatment Decisions in Early Breast Cancer: A Decision Impact Study
Prosigna Assay for Treatment Decisions in Early Breast Cancer: A Decision Impact Study Open
Introduction: Therapeutic decisions in early breast cancer are based on clinico-pathological features which are subject to intra- and inter-observer variability. This single-center decision impact study aimed to evaluate the effects of the…
Effect of Primary Testicular Tumor Localization on Prognosis and Survival of Non-seminomatous Testis Cancer Patients Open
Objective: Unlike left testicular vein, right testicular vein drains into inferior vena cava.Consequently, the systemic spread of testicular cancers in each side is expected to differ based on the vascular structures of the right and left …
Enzalutamide Treatment in Metastatic Castration-resistant Prostate Cancer: Before and after Docetaxel Open
PSA response, radiological response and duration of enzalutamide treatment may predict the improvement of survival in patients with mCRPC treated with enzalutamide. Key Words: Enzalutamide, Docetaxel, Castration-resistant prostate cancer, …
Clinicopathologic Features of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) s: A Single-Center Experience Open
Higher-grade and presence of metastasis at diagnosis are negative independent prognostic indicators of survival in patients with gastroenteropancreatic neuroendocrine tumors.
Prognostic value of the 2017 World Health Organization Classification System for gastric neuroendocrine tumors: A single-center experience Open
The WHO 2017 NET classification system may have low prognostic value for determining the prognosis of patients with G1 and G2 tumors. Radical surgery for G1 and G2 NETs did not improve PFS in our study.
Changes in Ovarian Cancer Prognosis, Ten Years Single Center Experience Open
ÖZETGİRİŞ ve AMAÇ: Over kanseri kadınlarda görülen beşinci en sık kanser olmakla birlikte jinekolojik kanserlere bağlı ölüm nedenleri arasında ilk sırada yer almaktadır.Çalışmamızda merkezimizde over kanseri nedeniyle tedavi verilen hastal…
Controversies in the efficacy of adjuvant chemotherapy in different epithelial ovarian carcinoma histologies Open
Aim: In this retrospective study, the efficacy of adjuvant chemotherapy and its contribution to prognosis were investigated in patients diagnosed with different subgroups of ovarian carcinoma at stages 1–3. Material and Method: Epithelial …
Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience Open
Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical an…
Effectiveness of bendamustine in relapsed or refractory lymphoma cases: a Turkish Oncology Group study Open
Introduction We aimed to investigate the efficacy and side effects of bendamustine in relapsed/refractory lymphoma patients in Turkey. Material and methods In this retrospective study, we included relapsed/refractory Hodgkin lymphoma (HL) …
Abstract P3-08-23: Prosigna assay for treatment decisions in early breast cancer: A single center, decision impact study Open
Background: Therapeutic decisions in early breast cancer (EBC) are based on clinical and pathological features, which are subject to intra- and inter-observer variability. Hence, in the era of precision medicine, there is growing need for …
Well differentiated neuroendocrine tumors, a single center experience Open
Purpose: The aim of this study is to analyze the demographic, histopathologic features of Neuroendocrine tumor (NET) cases and to underline the treatment approaches over seven years period in a high-volume cancer center. Methods: This stud…
Distribution of lymphomas in Turkey: data of 4239 cases from a single institution using the WHO classification Open
Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed betw…
View article: Pertuzumab, trastuzumab and taxane combination for visceral organ metastatic patients: Real life practice results
Pertuzumab, trastuzumab and taxane combination for visceral organ metastatic patients: Real life practice results Open
Background: Anti-HER2 agents were a breakthrough in the treatment of HER2-enriched breast cancer (BC). In this study, we aimed to describe the real-life efficacy and safety of pertuzumab-trastuzumab-taxane (PTT) combination in BC patients.…
Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey Open
The short- and long-term prognoses of HIV-negative patients with anal squamous cell carcinoma were good, and low-grade toxicity was rare, thereby demonstrating that these patients can be successfully treated in a real-life setting with fav…
Prognostic value of ABO blood group in patients with nonseminomatous testicular cancer who treated with autologous stem cell transplantation Open
Aim: Even though ABO blood group surface antigens are expressed in red blood cells, they can be observed in many normal and pathologic cells. Relationship between ABO blood groups and progression and prognosis of cancer has been mainly dem…
The Perspectives of Medical Oncology Specialists in Screening Methods of Cancer Open
ÖZET GİRİŞ ve AMAÇ: Kanserde mortalite ve morbiditenin azaltılmasının başlıca yolu tarama programları ile hastalık gelişiminin mümkün olduğunca erken tanı konularak yakalanması ve uygun müdahalelerin gerçekleştirilmesidir.Bu konuda topluma…
Short term real world safety data of pertuzumab use in HER2 targeted treatment of metastatic breast cancer Open
Introduction: With the development and widely use of HER2 targeted therapies, HER2 expressing metastatic breast cancer have no longer dismal prognosis as once expected. The combination of HER2 targeted therapies with chemotherapatic agents…
A critical analysis of publication rates of national oncology meeting abstracts in Turkey Open
Purpose: In this study our aim is to analyze the publication rates of abstracts, which were presented between 2006 and 2011 years in biennial National Cancer Meeting of Turkey (NCM) and Turkish Medical Oncology Society Meeting (TMOSM) and …
Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future Open
In the last decade, we have gained a deeper understanding of innate immune system. The mechanism of the continuous guarding of progressive mutations happening in a single cell was discovered and the production and the recognition of tumor …
A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer Open
A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology depar…