Ed White
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View article: Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease
Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease Open
Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the fastest types of cytoplasmic second messenger signalling in excitable cells. In the heart, rapid summation of the elementary events of calcium relea…
View article: Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts
Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts Open
Purkinje fibres (PFs) play an important role in some ventricular arrhythmias and acute ventricular stretch can evoke mechanically-induced arrhythmias. We tested whether Purkinje fibres, play a role in these arrhythmias. Pseudo-ECGs were re…
View article: Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease
Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease Open
Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the fastest types of cytoplasmic second messenger signalling in excitable cells. In the heart, rapid summation of the elementary events of calcium relea…
View article: Data supplement from Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease
Data supplement from Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease Open
This file contains correlative calcium and DNA-PAINT datasets acquired from both Ctrl-RV and MCT-RV groups, custom-written analysis code and output files.
View article: Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads
Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads Open
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale …
View article: Supplementary data from Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads
Supplementary data from Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads Open
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale …
View article: Comparison of changes in electrical activity, in isolated and<i>in vivo</i>hearts, induced by voluntary exercise in female rats
Comparison of changes in electrical activity, in isolated and<i>in vivo</i>hearts, induced by voluntary exercise in female rats Open
Regular mild exercise is recommended to the general population as beneficial to health. Regular exercise typically leads to structural and electrical remodelling of the heart but in human studies it is difficult to relate the extrinsic and…
View article: A super-resolution protocol to correlate structural underpinnings of fast second-messenger signalling in primary cell types
A super-resolution protocol to correlate structural underpinnings of fast second-messenger signalling in primary cell types Open
Nanometre-scale cellular information obtained through super-resolution microscopies are often unaccompanied by functional information, particularly transient and diffusible signals through which life is orchestrated in the nano-micrometre …
View article: Mechanical stimulation of endocardial Purkinje fibres can trigger ventricular arrhythmias
Mechanical stimulation of endocardial Purkinje fibres can trigger ventricular arrhythmias Open
Acute ventricular dilation can evoke mechanically-induced arrhythmias, our study investigated whether Purkinje fibres (PFs) may play a role. Changes in left ventricular (LV) pressure and pseudo-ECGs were measured in isolated, Langendorff-p…
View article: Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System
Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System Open
Pulmonary arterial hypertension (PAH) results in hypertrophic remodeling of the right ventricle (RV) to overcome increased pulmonary pressure. This increases the O2 consumption of the myocardium, and without a concomitant increase in energ…
View article: Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy
Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy Open
Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) calcium channel, is tightly clustered within these nanodomains. Sup…
View article: Inward Rectifier Current Downregulation Promotes Spontaneous Calcium Release in a Novel Model of Rat Ventricular Electrophysiology
Inward Rectifier Current Downregulation Promotes Spontaneous Calcium Release in a Novel Model of Rat Ventricular Electrophysiology Open
Aberrant intracellular calcium handling, as observed in diseases such as heart failure, promotes lethal ventricular arrhythmias and sudden cardiac death.Recent data from our laboratory suggests that reduced expression of the inward rectifi…
View article: Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats
Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats Open
We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV) failure and tested whether the observed APD restitution properties were responsib…
View article: Diastolic dysfunction in pulmonary artery hypertension: Creatine kinase and the potential therapeutic benefit of beta‐blockers
Diastolic dysfunction in pulmonary artery hypertension: Creatine kinase and the potential therapeutic benefit of beta‐blockers Open
Summary Passive properties of the myocardium influence diastolic filling and cardiac output. In heart failure, changes in contributors to the passive properties of the ventricle, such as titin and collagen, and loss of the metabolic enzyme…
View article: A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development
A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development Open
Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification sites. It is abundantly expressed in testis and muscle, with lower levels in the …
View article: Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension
Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension Open
Background— Heart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a change in the ion channel transcriptome of the atrioventricular (AV) node. Metho…