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View article: Ephedrannin A: A potent dual inhibitor of <scp>FAK</scp> and Src with anticancer effects
Ephedrannin A: A potent dual inhibitor of <span>FAK</span> and Src with anticancer effects Open
Cancer is the leading cause of death worldwide, and the development of effective treatments remains an important challenge. Here, we present ephedrannin A, a compound that exhibits strong anticancer activity against various types of cancer…
View article: Comparative Analysis of the Total Proteome in Nonalcoholic Steatohepatitis: Identification of Potential Biomarkers
Comparative Analysis of the Total Proteome in Nonalcoholic Steatohepatitis: Identification of Potential Biomarkers Open
Nonalcoholic fatty liver disease is a hepatic condition characterized by excessive fat accumulation in the liver with advanced stage nonalcoholic steatohepatitis (NASH), potentially leading to liver fibrosis, cirrhosis, and cancer. Current…
View article: Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma Open
Background Renal cancer therapies are challenging owing to the extensive spreading of this cancer to other organs and its ability to pose resistance to current medications. Therefore, drugs targeting novel targets are urgently required to …
View article: Discovery of 14-3-3 zeta as a potential biomarker for cardiac hypertrophy
Discovery of 14-3-3 zeta as a potential biomarker for cardiac hypertrophy Open
Acute myocardial infarction (AMI) is a multifaceted syndrome influenced by the functions of various extrinsic and intrinsic pathways and pathological processes, which can be detected in circulation using biomarkers. In this study, we inves…
View article: Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1
Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1 Open
Background Clear cell renal carcinoma is commonly known for its metastasis propensity to outspread to other organs and is asymptomatic in the early stage. Recent studies have shown that deficiencies in CYP11A1 expression can lead to fatal …
View article: Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1
Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1 Open
Background Clear cell renal carcinoma is commonly known for its metastasis propensity to outspread to other organs and does not exhibit symptoms in the early stage. Recent studies have shown that deficiencies in CYP11A1 expression can lead…