Edem Gavor
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View article: Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design
Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design Open
A major obstacle confronting HIV-1 vaccine and cure research is the lack of an outbred animal model for rapid and consistent induction of broadly neutralizing antibodies (bNAbs). We designed an epitope-focused simian-human immunodeficiency…
View article: Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes Open
A primary goal in the development of an AIDS vaccine is the elicitation of broadly neutralizing antibodies (bNAbs) that protect against diverse HIV-1 strains. To this aim, germline-targeting immunogens have been developed to activate bNAb …
View article: Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes Open
A primary goal in the development of an AIDS vaccine is the elicitation of broadly neutralizing antibodies (bNAbs) that protect against diverse HIV-1 strains. To this aim, germline-targeting immunogens have been developed to activate bNAb …
View article: Effect of the COVID-19 Pandemic on Respiratory Diseases and Their Economic Impacts
Effect of the COVID-19 Pandemic on Respiratory Diseases and Their Economic Impacts Open
COVID-19 is an airborne respiratory disease that mainly affects the lungs. To date, COVID-19 has infected 580 million people with a mortality of approximately 7 million people worldwide. The emergence of COVID-19 has also affected the infe…
View article: Recognition of Aedes aegypti Mosquito Saliva Protein LTRIN by the Human Receptor LTβR for Controlling the Immune Response
Recognition of Aedes aegypti Mosquito Saliva Protein LTRIN by the Human Receptor LTβR for Controlling the Immune Response Open
Salivary proteins from mosquitoes have received significant attention lately due to their potential to develop therapeutic treatments or vaccines for mosquito-borne diseases. Here, we report the characterization of LTRIN (lymphotoxin beta …
View article: Structural and functional characterization of <i>Aedes aegypti</i> pupal cuticle protein that controls dengue virus infection
Structural and functional characterization of <i>Aedes aegypti</i> pupal cuticle protein that controls dengue virus infection Open
The pupal cuticle protein from Aedes aegypti (AaPC) inhibits dengue virus (DENV) infection; however, the underlying mechanism of this inhibition remains unknown. Here, we report that AaPC is an intrinsically disordered protein and interact…
View article: Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins
Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins Open
Mosquito saliva proteins modulate the human immune and hemostatic systems and control mosquito-borne pathogenic infections. One mechanism through which mosquito proteins may influence host immunity and hemostasis is their interactions with…
View article: Structure of <i>Aedes aegypti</i> procarboxypeptidase B1 and its binding with Dengue virus for controlling infection
Structure of <i>Aedes aegypti</i> procarboxypeptidase B1 and its binding with Dengue virus for controlling infection Open
Metallocarboxypeptidases play critical roles in the development of mosquitoes and influence pathogen/parasite infection of the mosquito midgut. Here, we report the crystal structure of Aedes aegypti procarboxypeptidase B1 (PCPBAe1), charac…
View article: Structure of <i>Aedes aegypti</i> carboxypeptidase <scp>B1</scp>‐inhibitor complex uncover the disparity between mosquito and non‐mosquito insect carboxypeptidase inhibition mechanism
Structure of <i>Aedes aegypti</i> carboxypeptidase <span>B1</span>‐inhibitor complex uncover the disparity between mosquito and non‐mosquito insect carboxypeptidase inhibition mechanism Open
Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant‐feeding insects, represent…
View article: Over-expression of Id2 and Id3 Proteins Regulates Growth and Survival of Human Colon Carcinoma (HCT116) Cells
Over-expression of Id2 and Id3 Proteins Regulates Growth and Survival of Human Colon Carcinoma (HCT116) Cells Open
Inhibitor of differentiation (Id) proteins are members of the Helix-Loop-Helix (HLH) group of transcription factors.These proteins uniquely have no DNA-binding domain and they play vital roles in cell growth, differentiation, senescence, a…
View article: Down-regulation of Id1 and Id3 genes affects growth and survival of Human Umbilical Vein Endothelial Cells (HUVECs)
Down-regulation of Id1 and Id3 genes affects growth and survival of Human Umbilical Vein Endothelial Cells (HUVECs) Open
Inhibitors of DNA (Id) proteins have been implicated in cell growth, cell cycle control, apoptosis and angiogenesis.Studies reveal that Id1 and Id3 may be required for angiogenesis in adult tissues.This work aimed at investigating the cons…