Explanipedia

Glyco Ionic Liquids as Novel Nanoparticle Coatings to Enhance Triple‐Negative Breast Cancer Drug Delivery Open

Gaya S. Dasanayake, Christine M. Hamadani, Fikir Hailu, Iyanuoluwani Owolabi, Mira Patel , et al. · 2025

Targeted drug delivery seeks to revolutionize disease treatment by enhancing therapeutic efficacy and specificity. However, developing and achieving precisely targeted delivery remains a significant challenge, particularly in cancers such …

Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking Open

Purva Khare, Sara X. Edgecomb, Christine M. Hamadani, George R. Taylor, Rocco Caprara , et al. · 2025

Lipid nanoparticles ( LNPs ) have transformed the delivery of nucleic acid therapeutics; however, their natural tropism favors the liver resulting in clearance by the reticuloendothelial system, with less than 1% of the injected dose reach…

Insights into the physicochemical interactions of ionic liquid-coated polymeric nanoparticles with red blood cells Open

Christine M. Hamadani, George R. Taylor, Amber Cecil, Claylee M. Chism, Emilia Huff , et al. · 2025

We explore the mechanism behind in situ red blood cell hitchhiking by ionic liquid-coated nanoparticles, which can be leveraged for targeted drug delivery.

Glycopolymeric Nanoparticles Enrich Less Immunogenic Protein Coronas, Reduce Mononuclear Phagocyte Clearance, and Improve Tumor Delivery Compared to PEGylated Nanoparticles Open

Kenneth Hulugalla, Oluwaseyi Shofolawe-Bakare, Veeresh Toragall, Sk Arif Mohammad, Railey Mayatt , et al. · 2024

Nanoparticles (NPs) offer significant promise as drug delivery vehicles; however, their in vivo efficacy is often hindered by the formation of a protein corona (PC), which influences key physiological responses such as blood circula…

Cytotoxicity and cell membrane interactions of choline-based ionic liquids: Comparing amino acids, acetate, and geranate anions Open

Mohamad El Mohamad, Qi Han, Brendan Dyett, Haitao Yu, Sara X. Edgecomb , et al. · 2024

Ionic liquids (ILs) have found diverse applications in research and industry. Biocompatible ILs, a subset considered less toxic than traditional ILs, have expanded their applications into biomedical fields. However, there is limited unders…

Ionic Liquid Coating‐Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV Open

Christine M. Hamadani, Fakhri Mahdi, Anya Merrell, Jack Flanders, Ruofan Cao , et al. · 2024

Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus ca…

NIR-II emissive donor–acceptor–donor fluorophores for dual fluorescence bioimaging and photothermal therapy applications Open

Nicholas E. Sparks, Cameron Smith, Terrence L. Stahl, Dhanush L. Amarasekara, Christine M. Hamadani , et al. · 2024

Herein, we focus on the design, synthesis, and characterization of thienothiadiazole (TTD)-based near-infrared II (NIR-II) theranostic fluorophores and their nanoparticles.

Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets Open

Purva Khare, Sara X. Edgecomb, Christine M. Hamadani, James F. Conway, Eden E. L. Tanner , et al. · 2023

Ionic liquid (IL)-coated LNPs increase siRNA uptake into brain endothelial cells and motor neurons and lesser plasma proteins compared to standard LNPs.

Ionic-Liquid-Modified Nanoparticles as Potential Mucus Modulators for Nasal Drug Delivery Open

Mary Beth VanLandingham, Rebekah Heintz, Chathuri S. Kariyawasam, Donovan S. Darlington, Claylee M. Chism , et al. · 2023

Mucosal barriers are a natural defense system for preventing the entry of foreign objects into the body; however, they pose obstacles for effective drug delivery. Coated polymer nanoparticles (NPs) have been shown to possess improved rates…

Investigation of physicochemical drivers directing ionic liquid assembly on polymeric nanoparticles Open

Sara X. Edgecomb, Christine M. Hamadani, Angela Roberts, George Taylor, Anya Merrell , et al. · 2023

Ionic liquids (ILs) have emerged as promising biomaterials for enhancing drug delivery by functionalizing polymeric nanoparticles (NPs). Despite the biocompatibility and biofunctionalization they confer upon the NPs, little is understood r…

Selective Near-Infrared Blood Detection Driven by Ionic Liquid–Dye–Albumin Nanointeractions Open

Donovan S. Darlington, Allison N. Mahurin, Каріна Капуста, Ember Suh, Cameron Smith , et al. · 2023

Due to its abundance in blood, a great deal of research has been undertaken to develop efficient biosensors for serum albumin and provide insight into the interactions that take place between these biosensing molecules and the protein. Nea…

Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection Open

Christine M. Hamadani, Gaya S. Dasanayake, Claylee M. Chism, M. Górniak, Wake Monroe , et al. · 2023

Less than 5% of intravenously-injected nanoparticles (NPs) reach destined sites in the body due to opsonization and immune-based clearance in vascular circulation. By hitchhiking in situ onto specific blood components post-injection, NPs c…

Topical Administration of an Apoptosis Inducer Mitigates Bleomycin-Induced Skin Fibrosis Open

Md Nurul Huda, Edgar A. Borrego, Cristina D. Guerena, Armando Varela-Ramı́rez, Renato J. Aguilera , et al. · 2023

Pathological fibrosis is distinguished from physiological wound healing by persistent myofibroblast activation, suggesting that therapies that induce myofibroblast apoptosis selectively could prevent progression and potentially reverse the…

Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV Open

Christine M. Hamadani, Fakhri Mahdi, Anya Merrell, Jack Flanders, Ruofan Cao , et al. · 2023

The Impact of Water on Choline‐2‐Octenoic Ionic Liquid‐Facilitated Transdermal Transport (Adv. Therap. 1/2023) Open

Isabel R. Nichols, Christine M. Hamadani, Claylee M. Chism, Alysha N. Hunter, Humayun Ahmad , et al. · 2023

At 50% (v/v) water composition, the ionic liquid (IL) choline trans-2-octenoic acid (CA2OE 1:2) forms a lamellar-organized nanoparticle (cross-section) encapsulating fluorescent rhodamine-dextran (pink), which allows for deep penetration t…

Good's buffer based highly biocompatible ionic liquid modified PLGA nanoparticles for the selective uptake in cancer cells Open

Gagandeep Singh, Gaya S. Dasanayake, Claylee M. Chism, Priyavrat Vashisth, Amandeep Kaur , et al. · 2023

Schematic representation of preferential uptake of good's buffer-coated PLGA nanoparticles into human breast cancer cells. Created with biorender.com.

Latent bloodstain detection using a selective turn-on NIR fluorescence dye responsive to serum albumin Open

Jing Qu, William E. Meador, Pohlee Cheah, Eden E. L. Tanner, Jared H. Delcamp , et al. · 2023

Latent bloodstains can be visualized using a selective turn-on NIR fluorescence dye responsive to serum albumin. This non-destructive method can detect aged bloodstains and image latent blood fingerprint patterns against colorful backgroun…

ROS‐Responsive Glycopolymeric Nanoparticles for Enhanced Drug Delivery to Macrophages Open

Oluwaseyi Shofolawe-Bakare, Judith U. de Mel, Sushil K. Mishra, Mehjabeen Hossain, Christine M. Hamadani , et al. · 2022

Macrophages play a diverse, key role in many pathologies, including inflammatory diseases, cardiovascular diseases, and cancer. However, many therapeutic strategies targeting macrophages suffer from systemic off‐target toxicity resulting i…

Antimicrobial Effects of Anion Manipulation with Biocompatible Choline Carboxylic Acid-Based Ionic Liquids Open

Claylee M. Chism, Samuel Plash, Daniel M. Zuckerman, Gaya S. Dasanayake, Maria M. Bennett , et al. · 2022

Bacteria are constantly developing greater antibiotic resistance; therefore, safe, efficacious, and cost-effective antibiotics are urgently needed. Ionic liquids (ILs) show great promise as antimicrobial agents because of their ability to …

Ionic liquid-mediated delivery of a BCL-2 inhibitor for topical treatment of skin melanoma Open

Md Nurul Huda, Isaac G. Deaguero, Edgar A. Borrego, Raj Kumar, Tamanna Islam , et al. · 2022

A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson’s disease Open

Jayoung Kim, Yongsheng Gao, Zongmin Zhao, Danika Rodrigues, Eden E. L. Tanner , et al. · 2022

Significance Parkinson’s disease (PD) is a progressive disorder of the central nervous system that affects motor control. While subcutaneous injection of apomorphine (Apokyn) is clinically used to alleviate intermittent episodes of dyskine…

Ionic Liquid‐Mediated Transdermal Delivery of Thrombosis‐Detecting Nanosensors Open

Ahmet Bekdemir, Eden E. L. Tanner, Jesse D. Kirkpatrick, Ava P. Soleimany, Samir Mitragotri , et al. · 2022

Blood clotting disorders such as pulmonary embolism are associated with high morbidity and mortality. A large portion of thrombotic events occur postoperative and after hospital discharge. Therefore, easily applicable, noninvasive, and lon…

PLGA's Plight and the Role of Stealth Surface Modification Strategies in Its Use for Intravenous Particulate Drug Delivery Open

Violet V. Sheffey, Emily B. Siew, Eden E. L. Tanner, Omolola Eniola‐Adefeso · 2022

Numerous human disorders can benefit from targeted, intravenous (IV) drug delivery. Polymeric nanoparticles have been designed to undergo systemic circulation and deliver their therapeutic cargo to target sites in a controlled manner. Poly…

Latent Bloodstain Detection Using a Selective Turn-On Nir Fluorescence Dye Responsive to Serum Albumin Open

Jing Qu, William E. Meador, Pohlee Cheah, Eden E. L. Tanner, Jared H. Delcamp , et al. · 2022

processed for Eden n=4 exported size kinetics serum study for paper DiD NP updated for Nature protocols.xlsx Open

Eden E. L. Tanner · 2022

Exported size kinetics serum study

Improved nanoformulation and bio-functionalization of linear-dendritic block copolymers with biocompatible ionic liquids Open

Christine M. Hamadani, Indika Chandrasiri, Mahesh Loku Yaddehige, Gaya S. Dasanayake, Iyanuoluwani Owolabi , et al. · 2022

Ionic liquid-functionalized linear-dendritic block copolymer nanoparticles show facile assemblies and red blood cell hitchhiking in whole blood.

Recent Advances in Ionic Liquids in Biomedicine Open

Alexander M. Curreri, Samir Mitragotri, Eden E. L. Tanner · 2021

The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics…

Protein-avoidant ionic liquid (PAIL)–coated nanoparticles to increase bloodstream circulation and drive biodistribution Open

Christine M. Hamadani, Morgan J. Goetz, Samir Mitragotri, Eden E. L. Tanner · 2020

Ionic liquid–modified nanoparticles show extended circulation and redirected biodistribution in mice compared to control particles.

Ionic‐Liquid‐Based Safe Adjuvants Open

Anvay Ukidve, Katharina Cu, Morgan Goetz, Pavimol Angsantikul, Alexander M. Curreri , et al. · 2020

Adjuvants play a critical role in the design and development of novel vaccines. Despite extensive research, only a handful of vaccine adjuvants have been approved for human use. Currently used adjuvants are mostly composed of components th…

Reply to Peiretti et al.: Effect of CAGE on fat uptake and food intake Open

Md Nurunnabi, Kelly N. Ibsen, Eden E. L. Tanner, Samir Mitragotri · 2020

We thank Peiretti et al. (1) for their interest in our work (2) and for the suggestions for follow-up research. Peiretti et al. (1) ask about the role of reduced food consumption in the observed effect on reduced weight gain. We respectful…

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