Edgar Schmitt
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View article: CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production
CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production Open
Introduction Regulatory T-cells (T regs ) are characterized by the expression of Foxp3, a master regulator involved in the development and function of T regs . Foxp3 expression is dependent on activity of the Treg specific demethylated sit…
View article: Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host
Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host Open
View article: MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response
MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response Open
Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans (e.g., Tn antigen). Dendritic…
View article: The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response
The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response Open
Tumor‐associated carbohydrate antigens are overexpressed as altered‐self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells. Scientists have been develo…
View article: The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin Open
View article: Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer
Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer Open
There is still a great unmet medical need concerning diagnosis and treatment of breast cancer which could be addressed by utilizing specific molecular targets. Tumor-associated MUC1 is expressed on over 90 % of all breast cancer entities a…
View article: Cover Feature: Mannose‐Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen‐Presenting Cells (ChemBioChem 9/2018)
Cover Feature: Mannose‐Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen‐Presenting Cells (ChemBioChem 9/2018) Open
The cover feature picture shows the supramolecular copolymerisation of a dendritic peptide amphiphile monomer bearing mannosides and a second monomer carrying tetra(ethylene glycol)s and labelled with a Cy3 fluorescent probe. The multicomp…
View article: CCDC 1583576: Experimental Crystal Structure Determination
CCDC 1583576: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1532063: Experimental Crystal Structure Determination
CCDC 1532063: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice
Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice Open
This study focused on the unique properties of both the Ldlr knockout defect (closely mimicking the human situation) and the BALB/c (C) inbred mouse strain (Th-2 slanted immune response). We generated two immunodeficient strains with sever…
View article: Protein kinase CK2 governs the molecular decision between encephalitogenic T <sub>H</sub> 17 cell and T <sub>reg</sub> cell development
Protein kinase CK2 governs the molecular decision between encephalitogenic T <sub>H</sub> 17 cell and T <sub>reg</sub> cell development Open
Significance Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system in the western world and leads to devastating disability in young adults, with only limited treatment options currently avai…
View article: Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells
Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells Open
Coevolution of ticks and the vertebrate immune system has led to the development of immunosuppressive molecules that prevent immediate response of skin-resident immune cells to quickly fend off the parasite. In this article, we demonstrate…
View article: Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epitope
Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epitope Open
The development of selective anticancer vaccines that provide enhanced protection against tumor recurrence and metastasis has been the subject of intense research in the scientific community. The tumor-associated glycoprotein MUC1 represen…
View article: Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers
Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers Open
A fully synthetic multivalent MUC1 glycopeptide vaccine based on a hyperbranched polyglycerol core induced IgG antibodies which strongly recognise epithelial tumour cells.